Breast cancer heterogeneity and its implication in personalized precision therapy
Abstract Breast cancer heterogeneity determines cancer progression, treatment effects, and prognosis. However, the precise mechanism for this heterogeneity remains unknown owing to its complexity. Here, we summarize the origins of breast cancer heterogeneity and its influence on disease progression,...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-01-01
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| Series: | Experimental Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40164-022-00363-1 |
| _version_ | 1827329345532723200 |
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| author | Liantao Guo Deguang Kong Jianhua Liu Ling Zhan Lan Luo Weijie Zheng Qingyuan Zheng Chuang Chen Shengrong Sun |
| author_facet | Liantao Guo Deguang Kong Jianhua Liu Ling Zhan Lan Luo Weijie Zheng Qingyuan Zheng Chuang Chen Shengrong Sun |
| author_sort | Liantao Guo |
| collection | DOAJ |
| description | Abstract Breast cancer heterogeneity determines cancer progression, treatment effects, and prognosis. However, the precise mechanism for this heterogeneity remains unknown owing to its complexity. Here, we summarize the origins of breast cancer heterogeneity and its influence on disease progression, recurrence, and therapeutic resistance. We review the possible mechanisms of heterogeneity and the research methods used to analyze it. We also highlight the importance of cell interactions for the origins of breast cancer heterogeneity, which can be further categorized into cooperative and competitive interactions. Finally, we provide new insights into precise individual treatments based on heterogeneity. |
| first_indexed | 2024-03-07T15:31:43Z |
| format | Article |
| id | doaj.art-6d7332617b73497aa1cfa4022e682b07 |
| institution | Directory Open Access Journal |
| issn | 2162-3619 |
| language | English |
| last_indexed | 2024-03-07T15:31:43Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Experimental Hematology & Oncology |
| spelling | doaj.art-6d7332617b73497aa1cfa4022e682b072024-03-05T16:22:12ZengBMCExperimental Hematology & Oncology2162-36192023-01-0112112710.1186/s40164-022-00363-1Breast cancer heterogeneity and its implication in personalized precision therapyLiantao Guo0Deguang Kong1Jianhua Liu2Ling Zhan3Lan Luo4Weijie Zheng5Qingyuan Zheng6Chuang Chen7Shengrong Sun8Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan UniversityDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan UniversityDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan UniversityDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan UniversityDepartment of Breast Surgery, The Affiliated Hospital of Guizhou Medical UniversityDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan UniversityDepartment of Urology, Renmin Hospital of Wuhan UniversityDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan UniversityDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan UniversityAbstract Breast cancer heterogeneity determines cancer progression, treatment effects, and prognosis. However, the precise mechanism for this heterogeneity remains unknown owing to its complexity. Here, we summarize the origins of breast cancer heterogeneity and its influence on disease progression, recurrence, and therapeutic resistance. We review the possible mechanisms of heterogeneity and the research methods used to analyze it. We also highlight the importance of cell interactions for the origins of breast cancer heterogeneity, which can be further categorized into cooperative and competitive interactions. Finally, we provide new insights into precise individual treatments based on heterogeneity.https://doi.org/10.1186/s40164-022-00363-1Breast cancerHeterogeneityCell interactionCell competitionPrecision therapy |
| spellingShingle | Liantao Guo Deguang Kong Jianhua Liu Ling Zhan Lan Luo Weijie Zheng Qingyuan Zheng Chuang Chen Shengrong Sun Breast cancer heterogeneity and its implication in personalized precision therapy Experimental Hematology & Oncology Breast cancer Heterogeneity Cell interaction Cell competition Precision therapy |
| title | Breast cancer heterogeneity and its implication in personalized precision therapy |
| title_full | Breast cancer heterogeneity and its implication in personalized precision therapy |
| title_fullStr | Breast cancer heterogeneity and its implication in personalized precision therapy |
| title_full_unstemmed | Breast cancer heterogeneity and its implication in personalized precision therapy |
| title_short | Breast cancer heterogeneity and its implication in personalized precision therapy |
| title_sort | breast cancer heterogeneity and its implication in personalized precision therapy |
| topic | Breast cancer Heterogeneity Cell interaction Cell competition Precision therapy |
| url | https://doi.org/10.1186/s40164-022-00363-1 |
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