Hemoglobinopathies: ocular manifestations in children and adolescents
Hemoglobinopathies are genetic disorders that lead to abnormal structure of the hemoglobin molecule. Sickle cell disease, the most common inherited blood disorder, is characterized by defective oxygen transport. Almost every part of the eye can be affected by sickle cell disease; however, proliferat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-06-01
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| Series: | Therapeutic Advances in Ophthalmology |
| Online Access: | https://doi.org/10.1177/25158414211022882 |
| _version_ | 1819154244900487168 |
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| author | Omar Moussa Royce W.S. Chen |
| author_facet | Omar Moussa Royce W.S. Chen |
| author_sort | Omar Moussa |
| collection | DOAJ |
| description | Hemoglobinopathies are genetic disorders that lead to abnormal structure of the hemoglobin molecule. Sickle cell disease, the most common inherited blood disorder, is characterized by defective oxygen transport. Almost every part of the eye can be affected by sickle cell disease; however, proliferative sickle cell retinopathy is the primary cause of vision loss, either from vitreous hemorrhage or retinal detachment. Here we review the various manifestations of hemoglobinopathies on the eyes of children and adolescents, with a specific focus on sickle cell disease and its different phenotypes. Newer, more sensitive ophthalmological imaging modalities, including ultra-widefield fluorescein angiography, spectral-domain optical coherence tomography, and optical coherence tomography angiography, are available. These sensitive modalities allow for a more thorough examination of the retinal periphery where sickle cell retinopathy is often present. Utilization of such modalities will help with the early detection of the disease in children, which provide a better understanding of the pathogenesis of the disease and guide future screening and treatment regimens. |
| first_indexed | 2024-12-22T15:18:00Z |
| format | Article |
| id | doaj.art-6d739cc1028747e8b3a9c94ba91aa251 |
| institution | Directory Open Access Journal |
| issn | 2515-8414 |
| language | English |
| last_indexed | 2024-12-22T15:18:00Z |
| publishDate | 2021-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Ophthalmology |
| spelling | doaj.art-6d739cc1028747e8b3a9c94ba91aa2512022-12-21T18:21:41ZengSAGE PublishingTherapeutic Advances in Ophthalmology2515-84142021-06-011310.1177/25158414211022882Hemoglobinopathies: ocular manifestations in children and adolescentsOmar MoussaRoyce W.S. ChenHemoglobinopathies are genetic disorders that lead to abnormal structure of the hemoglobin molecule. Sickle cell disease, the most common inherited blood disorder, is characterized by defective oxygen transport. Almost every part of the eye can be affected by sickle cell disease; however, proliferative sickle cell retinopathy is the primary cause of vision loss, either from vitreous hemorrhage or retinal detachment. Here we review the various manifestations of hemoglobinopathies on the eyes of children and adolescents, with a specific focus on sickle cell disease and its different phenotypes. Newer, more sensitive ophthalmological imaging modalities, including ultra-widefield fluorescein angiography, spectral-domain optical coherence tomography, and optical coherence tomography angiography, are available. These sensitive modalities allow for a more thorough examination of the retinal periphery where sickle cell retinopathy is often present. Utilization of such modalities will help with the early detection of the disease in children, which provide a better understanding of the pathogenesis of the disease and guide future screening and treatment regimens.https://doi.org/10.1177/25158414211022882 |
| spellingShingle | Omar Moussa Royce W.S. Chen Hemoglobinopathies: ocular manifestations in children and adolescents Therapeutic Advances in Ophthalmology |
| title | Hemoglobinopathies: ocular manifestations in children and adolescents |
| title_full | Hemoglobinopathies: ocular manifestations in children and adolescents |
| title_fullStr | Hemoglobinopathies: ocular manifestations in children and adolescents |
| title_full_unstemmed | Hemoglobinopathies: ocular manifestations in children and adolescents |
| title_short | Hemoglobinopathies: ocular manifestations in children and adolescents |
| title_sort | hemoglobinopathies ocular manifestations in children and adolescents |
| url | https://doi.org/10.1177/25158414211022882 |
| work_keys_str_mv | AT omarmoussa hemoglobinopathiesocularmanifestationsinchildrenandadolescents AT roycewschen hemoglobinopathiesocularmanifestationsinchildrenandadolescents |