Comparison of FLASH Proton Entrance and the Spread-Out Bragg Peak Dose Regions in the Sparing of Mouse Intestinal Crypts and in a Pancreatic Tumor Model

Comparison of FLASH Proton Entrance and the Spread-Out Bragg Peak Dose Regions in the Sparing of Mouse Intestinal Crypts and in a Pancreatic Tumor Model

Ultra-high dose rate FLASH proton radiotherapy (F-PRT) has been shown to reduce normal tissue toxicity compared to standard dose rate proton radiotherapy (S-PRT) in experiments using the entrance portion of the proton depth dose profile, while proton therapy uses a spread-out Bragg peak (SOBP) with...

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Bibliographic Details
Main Authors: Michele M. Kim, Ioannis I. Verginadis, Denisa Goia, Allison Haertter, Khayrullo Shoniyozov, Wei Zou, Amit Maity, Theresa M. Busch, James M. Metz, Keith A. Cengel, Lei Dong, Costas Koumenis, Eric S. Diffenderfer
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
proton FLASH radiation
spread-out Bragg peak
Online Access:https://www.mdpi.com/2072-6694/13/16/4244

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