Fucoidan from Cladosiphon okamuranus enhances antioxidant activity and prevents reproductive dysfunction in polystyrene microplastic-induced male rats
Plastic pollution, including microplastic, has emerged as a severe environmental and public health problem. The health risks, especially in the case of reproductive damage caused by polystyrene microplastic (PS-MP) exposure, are emerging problems that need to be solved. This study aimed to investiga...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223017109 |
| _version_ | 1797403642834190336 |
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| author | Yi-Yuh Hwang Sabri Sudirman En-Yu Wei Zwe-Ling Kong Deng-Fwu Hwang |
| author_facet | Yi-Yuh Hwang Sabri Sudirman En-Yu Wei Zwe-Ling Kong Deng-Fwu Hwang |
| author_sort | Yi-Yuh Hwang |
| collection | DOAJ |
| description | Plastic pollution, including microplastic, has emerged as a severe environmental and public health problem. The health risks, especially in the case of reproductive damage caused by polystyrene microplastic (PS-MP) exposure, are emerging problems that need to be solved. This study aimed to investigate the effects of fucoidan extracted from Cladosiphon okamuranus on the polystyrene microplastic-induced oxidative stress of the Leydig (LC540) cells and reproductive damage in male rats. The oxidative stress of the LC540 cells and reproductive damage in the rats were induced by PS-MP. The fucoidan treatment reduces nitric oxide (NO) and reactive oxygen species generation in the LC540 cells. In the animal study, fucoidan treatment enhanced enzymatic antioxidant activities (glutathione peroxidase, superoxide dismutase, glucose-6-phosphate dehydrogenase, and glutathione reductase) and reduced malondialdehyde and nitric oxide production. Fucoidan supplementation also downregulates tumor necrosis factor-alpha, interleukin-6, and caspase-3 expression. Additionally, fucoidan upregulates testosterone levels, prevents the reduction of epithelium thickness, and reduces the area of the seminiferous tubule lumen. According to these conditions, fucoidan from Cladosiphon okamuranus prevents reproductive damage by downregulating oxidative stress and pro-inflammatory cytokines. Therefore, fucoidan can be used as a source of food supplements or functional food ingredients for reproductive or testicular damage management. |
| first_indexed | 2024-03-09T02:41:20Z |
| format | Article |
| id | doaj.art-6d77d1fb83504aada3ae139e4ab681f7 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-09T02:41:20Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-6d77d1fb83504aada3ae139e4ab681f72023-12-06T04:17:06ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-01-01170115912Fucoidan from Cladosiphon okamuranus enhances antioxidant activity and prevents reproductive dysfunction in polystyrene microplastic-induced male ratsYi-Yuh Hwang0Sabri Sudirman1En-Yu Wei2Zwe-Ling Kong3Deng-Fwu Hwang4Department of Food Science, National Taiwan Ocean University, Keelung City 20224, TaiwanFisheries Product Technology, Faculty of Agriculture, Universitas Sriwijaya, Indralaya 30862, IndonesiaDepartment of Food Science, National Taiwan Ocean University, Keelung City 20224, TaiwanDepartment of Food Science, National Taiwan Ocean University, Keelung City 20224, Taiwan; Corresponding authors.Department of Food Science, National Taiwan Ocean University, Keelung City 20224, Taiwan; Corresponding authors.Plastic pollution, including microplastic, has emerged as a severe environmental and public health problem. The health risks, especially in the case of reproductive damage caused by polystyrene microplastic (PS-MP) exposure, are emerging problems that need to be solved. This study aimed to investigate the effects of fucoidan extracted from Cladosiphon okamuranus on the polystyrene microplastic-induced oxidative stress of the Leydig (LC540) cells and reproductive damage in male rats. The oxidative stress of the LC540 cells and reproductive damage in the rats were induced by PS-MP. The fucoidan treatment reduces nitric oxide (NO) and reactive oxygen species generation in the LC540 cells. In the animal study, fucoidan treatment enhanced enzymatic antioxidant activities (glutathione peroxidase, superoxide dismutase, glucose-6-phosphate dehydrogenase, and glutathione reductase) and reduced malondialdehyde and nitric oxide production. Fucoidan supplementation also downregulates tumor necrosis factor-alpha, interleukin-6, and caspase-3 expression. Additionally, fucoidan upregulates testosterone levels, prevents the reduction of epithelium thickness, and reduces the area of the seminiferous tubule lumen. According to these conditions, fucoidan from Cladosiphon okamuranus prevents reproductive damage by downregulating oxidative stress and pro-inflammatory cytokines. Therefore, fucoidan can be used as a source of food supplements or functional food ingredients for reproductive or testicular damage management.http://www.sciencedirect.com/science/article/pii/S0753332223017109AntioxidantsFucoidanMicroplasticReproductive function |
| spellingShingle | Yi-Yuh Hwang Sabri Sudirman En-Yu Wei Zwe-Ling Kong Deng-Fwu Hwang Fucoidan from Cladosiphon okamuranus enhances antioxidant activity and prevents reproductive dysfunction in polystyrene microplastic-induced male rats Biomedicine & Pharmacotherapy Antioxidants Fucoidan Microplastic Reproductive function |
| title | Fucoidan from Cladosiphon okamuranus enhances antioxidant activity and prevents reproductive dysfunction in polystyrene microplastic-induced male rats |
| title_full | Fucoidan from Cladosiphon okamuranus enhances antioxidant activity and prevents reproductive dysfunction in polystyrene microplastic-induced male rats |
| title_fullStr | Fucoidan from Cladosiphon okamuranus enhances antioxidant activity and prevents reproductive dysfunction in polystyrene microplastic-induced male rats |
| title_full_unstemmed | Fucoidan from Cladosiphon okamuranus enhances antioxidant activity and prevents reproductive dysfunction in polystyrene microplastic-induced male rats |
| title_short | Fucoidan from Cladosiphon okamuranus enhances antioxidant activity and prevents reproductive dysfunction in polystyrene microplastic-induced male rats |
| title_sort | fucoidan from cladosiphon okamuranus enhances antioxidant activity and prevents reproductive dysfunction in polystyrene microplastic induced male rats |
| topic | Antioxidants Fucoidan Microplastic Reproductive function |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223017109 |
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