The expression of Ki-67 marker in the hydatidiform mole
Background: The hydatiform mole is charcaterized by a pathological proliferation of the trophoblast. Its evaluation could predict the progression to gestational trophoblastic neoplasia. The aim of the study was the analysis of the proliferative activity of the villous trophoblast in the molar vs non...
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| Language: | English |
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Scientific Medical Association of Moldova
2022-12-01
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| Series: | The Moldovan Medical Journal |
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| Online Access: | https://moldmedjournal.md/wp-content/uploads/2022/12/moldovan-med-j-2022-65-2-carpenco-et-al-full-text.pdf |
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| author | Ecaterina Carpenco Vergil Petrovici Lilia Sinitina Veaceslav Fulga Valeriu David |
| author_facet | Ecaterina Carpenco Vergil Petrovici Lilia Sinitina Veaceslav Fulga Valeriu David |
| author_sort | Ecaterina Carpenco |
| collection | DOAJ |
| description | Background: The hydatiform mole is charcaterized by a pathological proliferation of the trophoblast. Its evaluation could predict the progression to gestational trophoblastic neoplasia. The aim of the study was the analysis of the proliferative activity of the villous trophoblast in the molar vs non-molar lesions.
Material and methods: p-57 and Ki-67 were evaluated by immunohistochemistry in 15 cases of hydatidiform mole and 18 cases of abortions.
Results: The hydatidiform mole was divided based on the immunoexpression of anti-p57 into: complete (8 cases) and partial type (7 cases). The distribution score of Ki67 immunoreactivity in the villous cytotrophoblast was: complete mole: +3 – 8 cases; partial mole: +1 – 1 case, +2 – 3 cases, +3 – 3 cases; abortions on social indications: +1 – 6 cases, +2 – 9 cases; +3 – 2 cases. The mean and standard deviations were: 2.88±0.354; 2.29±0.756 and 1.82±0.728, respectively. The following statistical correlations were determined: complete vs partial mole (p=0.014), complete mole vs abortion (p<0.01) and overall cases of mole vs abortion (p=0.000034).
Conclusions: Villous cytotrophoblast proliferative activity is high in the complete hydatidiform mole, and the immunoreactivity distribution index is highly positive and statistically true in the molar versus non-molar group. Immunohistochemical evaluation of Ki-67 in molar pathology is useful in differential diagnosis as a complementary method. |
| first_indexed | 2024-04-11T04:43:25Z |
| format | Article |
| id | doaj.art-6d77de6090034aa2922f6c7a81e88be5 |
| institution | Directory Open Access Journal |
| issn | 2537-6373 2537-6381 |
| language | English |
| last_indexed | 2024-04-11T04:43:25Z |
| publishDate | 2022-12-01 |
| publisher | Scientific Medical Association of Moldova |
| record_format | Article |
| series | The Moldovan Medical Journal |
| spelling | doaj.art-6d77de6090034aa2922f6c7a81e88be52022-12-27T18:55:40ZengScientific Medical Association of MoldovaThe Moldovan Medical Journal2537-63732537-63812022-12-016521319https://doi.org/10.52418/moldovan-med-j.65-2.22.02The expression of Ki-67 marker in the hydatidiform moleEcaterina Carpenco0https://orcid.org/0000-0003-1464-3149Vergil Petrovici1https://orcid.org/0000-0001-8352-4202Lilia Sinitina2https://orcid.org/0000-0001-9646-8860Veaceslav Fulga3https://orcid.org/0000-0002-7589-7188Valeriu David4https://orcid.org/0000-0001-9799-7369Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaNicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaNicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaNicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaNicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaBackground: The hydatiform mole is charcaterized by a pathological proliferation of the trophoblast. Its evaluation could predict the progression to gestational trophoblastic neoplasia. The aim of the study was the analysis of the proliferative activity of the villous trophoblast in the molar vs non-molar lesions. Material and methods: p-57 and Ki-67 were evaluated by immunohistochemistry in 15 cases of hydatidiform mole and 18 cases of abortions. Results: The hydatidiform mole was divided based on the immunoexpression of anti-p57 into: complete (8 cases) and partial type (7 cases). The distribution score of Ki67 immunoreactivity in the villous cytotrophoblast was: complete mole: +3 – 8 cases; partial mole: +1 – 1 case, +2 – 3 cases, +3 – 3 cases; abortions on social indications: +1 – 6 cases, +2 – 9 cases; +3 – 2 cases. The mean and standard deviations were: 2.88±0.354; 2.29±0.756 and 1.82±0.728, respectively. The following statistical correlations were determined: complete vs partial mole (p=0.014), complete mole vs abortion (p<0.01) and overall cases of mole vs abortion (p=0.000034). Conclusions: Villous cytotrophoblast proliferative activity is high in the complete hydatidiform mole, and the immunoreactivity distribution index is highly positive and statistically true in the molar versus non-molar group. Immunohistochemical evaluation of Ki-67 in molar pathology is useful in differential diagnosis as a complementary method.https://moldmedjournal.md/wp-content/uploads/2022/12/moldovan-med-j-2022-65-2-carpenco-et-al-full-text.pdfhydatidiform moleki-67trophoblastic proliferation |
| spellingShingle | Ecaterina Carpenco Vergil Petrovici Lilia Sinitina Veaceslav Fulga Valeriu David The expression of Ki-67 marker in the hydatidiform mole The Moldovan Medical Journal hydatidiform mole ki-67 trophoblastic proliferation |
| title | The expression of Ki-67 marker in the hydatidiform mole |
| title_full | The expression of Ki-67 marker in the hydatidiform mole |
| title_fullStr | The expression of Ki-67 marker in the hydatidiform mole |
| title_full_unstemmed | The expression of Ki-67 marker in the hydatidiform mole |
| title_short | The expression of Ki-67 marker in the hydatidiform mole |
| title_sort | expression of ki 67 marker in the hydatidiform mole |
| topic | hydatidiform mole ki-67 trophoblastic proliferation |
| url | https://moldmedjournal.md/wp-content/uploads/2022/12/moldovan-med-j-2022-65-2-carpenco-et-al-full-text.pdf |
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