Platelet serotonin level predicts survival in amyotrophic lateral sclerosis.
<h4>Background</h4>Amyotrophic lateral sclerosis (ALS) is a life-threatening neurodegenerative disease involving upper and lower motor neurons loss. Clinical features are highly variable among patients and there are currently few known disease-modifying factors underlying this heterogene...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-10-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20967129/pdf/?tool=EBI |
| _version_ | 1818834336976207872 |
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| author | Luc Dupuis Odile Spreux-Varoquaux Gilbert Bensimon Philippe Jullien Lucette Lacomblez François Salachas Gaëlle Bruneteau Pierre-François Pradat Jean-Philippe Loeffler Vincent Meininger |
| author_facet | Luc Dupuis Odile Spreux-Varoquaux Gilbert Bensimon Philippe Jullien Lucette Lacomblez François Salachas Gaëlle Bruneteau Pierre-François Pradat Jean-Philippe Loeffler Vincent Meininger |
| author_sort | Luc Dupuis |
| collection | DOAJ |
| description | <h4>Background</h4>Amyotrophic lateral sclerosis (ALS) is a life-threatening neurodegenerative disease involving upper and lower motor neurons loss. Clinical features are highly variable among patients and there are currently few known disease-modifying factors underlying this heterogeneity. Serotonin is involved in a range of functions altered in ALS, including motor neuron excitability and energy metabolism. However, whether serotoninergic activity represents a disease modifier of ALS natural history remains unknown.<h4>Methodology</h4>Platelet and plasma unconjugated concentrations of serotonin and plasma 5-HIAA, the major serotonin metabolite, levels were measured using HPLC with coulometric detection in a cohort of 85 patients with ALS all followed-up until death and compared to a control group of 29 subjects.<h4>Principal findings</h4>Platelet serotonin levels were significantly decreased in ALS patients. Platelet serotonin levels did not correlate with disease duration but were positively correlated with survival of the patients. Univariate Cox model analysis showed a 57% decreased risk of death for patients with platelet serotonin levels in the normal range relative to patients with abnormally low platelet serotonin (p = 0.0195). This protective effect remained significant after adjustment with age, gender or site of onset in multivariate analysis. Plasma unconjugated serotonin and 5-HIAA levels were unchanged in ALS patients compared to controls and did not correlate with clinical parameters.<h4>Conclusions/significance</h4>The positive correlation between platelet serotonin levels and survival strongly suggests that serotonin influences the course of ALS disease. |
| first_indexed | 2024-12-19T02:33:12Z |
| format | Article |
| id | doaj.art-6d79b37c074f418c8d2e8f6600ba01a4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T02:33:12Z |
| publishDate | 2010-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6d79b37c074f418c8d2e8f6600ba01a42022-12-21T20:39:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-10-01510e1334610.1371/journal.pone.0013346Platelet serotonin level predicts survival in amyotrophic lateral sclerosis.Luc DupuisOdile Spreux-VaroquauxGilbert BensimonPhilippe JullienLucette LacomblezFrançois SalachasGaëlle BruneteauPierre-François PradatJean-Philippe LoefflerVincent Meininger<h4>Background</h4>Amyotrophic lateral sclerosis (ALS) is a life-threatening neurodegenerative disease involving upper and lower motor neurons loss. Clinical features are highly variable among patients and there are currently few known disease-modifying factors underlying this heterogeneity. Serotonin is involved in a range of functions altered in ALS, including motor neuron excitability and energy metabolism. However, whether serotoninergic activity represents a disease modifier of ALS natural history remains unknown.<h4>Methodology</h4>Platelet and plasma unconjugated concentrations of serotonin and plasma 5-HIAA, the major serotonin metabolite, levels were measured using HPLC with coulometric detection in a cohort of 85 patients with ALS all followed-up until death and compared to a control group of 29 subjects.<h4>Principal findings</h4>Platelet serotonin levels were significantly decreased in ALS patients. Platelet serotonin levels did not correlate with disease duration but were positively correlated with survival of the patients. Univariate Cox model analysis showed a 57% decreased risk of death for patients with platelet serotonin levels in the normal range relative to patients with abnormally low platelet serotonin (p = 0.0195). This protective effect remained significant after adjustment with age, gender or site of onset in multivariate analysis. Plasma unconjugated serotonin and 5-HIAA levels were unchanged in ALS patients compared to controls and did not correlate with clinical parameters.<h4>Conclusions/significance</h4>The positive correlation between platelet serotonin levels and survival strongly suggests that serotonin influences the course of ALS disease.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20967129/pdf/?tool=EBI |
| spellingShingle | Luc Dupuis Odile Spreux-Varoquaux Gilbert Bensimon Philippe Jullien Lucette Lacomblez François Salachas Gaëlle Bruneteau Pierre-François Pradat Jean-Philippe Loeffler Vincent Meininger Platelet serotonin level predicts survival in amyotrophic lateral sclerosis. PLoS ONE |
| title | Platelet serotonin level predicts survival in amyotrophic lateral sclerosis. |
| title_full | Platelet serotonin level predicts survival in amyotrophic lateral sclerosis. |
| title_fullStr | Platelet serotonin level predicts survival in amyotrophic lateral sclerosis. |
| title_full_unstemmed | Platelet serotonin level predicts survival in amyotrophic lateral sclerosis. |
| title_short | Platelet serotonin level predicts survival in amyotrophic lateral sclerosis. |
| title_sort | platelet serotonin level predicts survival in amyotrophic lateral sclerosis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20967129/pdf/?tool=EBI |
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