In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating
Yonggang Dang,1 Li Zhang,1 Wen Song,1 Bei Chang,1 Tianxiao Han,1 Yumei Zhang,1 Lingzhou Zhao2 1Department of Prosthetic Dentistry, 2Department of Periodontology, School of Stomatology, State Key Laboratory of Military Stomatology, The Fourth Military Medical University, Xi’an, People&...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-03-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/in-vivo-osseointegration-of-ti-implants-with-a-strontium-containing-na-peer-reviewed-article-IJN |
| _version_ | 1818845030673022976 |
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| author | Dang Y Zhang L Song W Chang B Han T Zhang Y Zhao L |
| author_facet | Dang Y Zhang L Song W Chang B Han T Zhang Y Zhao L |
| author_sort | Dang Y |
| collection | DOAJ |
| description | Yonggang Dang,1 Li Zhang,1 Wen Song,1 Bei Chang,1 Tianxiao Han,1 Yumei Zhang,1 Lingzhou Zhao2 1Department of Prosthetic Dentistry, 2Department of Periodontology, School of Stomatology, State Key Laboratory of Military Stomatology, The Fourth Military Medical University, Xi’an, People’s Republic of China Abstract: Novel biomedical titanium (Ti) implants with high osteogenic ability for fast and good osseointegration under normal as well as osteoporotic conditions are urgently needed. Expanding on our previous in vitro results, we hypothesized that nanotubular, strontium-loaded (NT-Sr) structures on Ti implants would have favorable osteogenic effects and evaluated the in vivo osseointegration of these implants in rats. The structures with nanotubes of different diameters were fabricated by electrochemical anodization at 10 and 40 V, and the amounts of Sr loaded were adjusted by using two hydrothermal treatment times of 1 and 3 hours. Qualitative microcomputed tomography in two and three dimensions showed that the NT-Sr formed with an anodization voltage of 10 V and hydrothermal treatment time of 3 hours best supported bone growth in vivo. Histomorphometric examination of osseointegration also showed that more newly formed bone was found at its surface. The bone–implant contact percentage was highest (92.48%±0.76%) at 12 weeks. In conclusion, the NT-Sr formed with an anodization voltage of 10 V and hydrothermal treatment time of 3 hours showed excellent osteogenic properties, making it an attractive option for Ti surface modification with considerable clinical potential. Keywords: titania nanotubes, strontium, osseointegration, in vivo |
| first_indexed | 2024-12-19T05:23:11Z |
| format | Article |
| id | doaj.art-6d7b5ccc98a9478a990d3fe4849af56c |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-19T05:23:11Z |
| publishDate | 2016-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-6d7b5ccc98a9478a990d3fe4849af56c2022-12-21T20:34:26ZengDove Medical PressInternational Journal of Nanomedicine1178-20132016-03-012016default1003101125967In vivo osseointegration of Ti implants with a strontium-containing nanotubular coatingDang YZhang LSong WChang BHan TZhang YZhao LYonggang Dang,1 Li Zhang,1 Wen Song,1 Bei Chang,1 Tianxiao Han,1 Yumei Zhang,1 Lingzhou Zhao2 1Department of Prosthetic Dentistry, 2Department of Periodontology, School of Stomatology, State Key Laboratory of Military Stomatology, The Fourth Military Medical University, Xi’an, People’s Republic of China Abstract: Novel biomedical titanium (Ti) implants with high osteogenic ability for fast and good osseointegration under normal as well as osteoporotic conditions are urgently needed. Expanding on our previous in vitro results, we hypothesized that nanotubular, strontium-loaded (NT-Sr) structures on Ti implants would have favorable osteogenic effects and evaluated the in vivo osseointegration of these implants in rats. The structures with nanotubes of different diameters were fabricated by electrochemical anodization at 10 and 40 V, and the amounts of Sr loaded were adjusted by using two hydrothermal treatment times of 1 and 3 hours. Qualitative microcomputed tomography in two and three dimensions showed that the NT-Sr formed with an anodization voltage of 10 V and hydrothermal treatment time of 3 hours best supported bone growth in vivo. Histomorphometric examination of osseointegration also showed that more newly formed bone was found at its surface. The bone–implant contact percentage was highest (92.48%±0.76%) at 12 weeks. In conclusion, the NT-Sr formed with an anodization voltage of 10 V and hydrothermal treatment time of 3 hours showed excellent osteogenic properties, making it an attractive option for Ti surface modification with considerable clinical potential. Keywords: titania nanotubes, strontium, osseointegration, in vivohttps://www.dovepress.com/in-vivo-osseointegration-of-ti-implants-with-a-strontium-containing-na-peer-reviewed-article-IJNTitania nanotubesStrontiumOsseointegrationIn vivo |
| spellingShingle | Dang Y Zhang L Song W Chang B Han T Zhang Y Zhao L In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating International Journal of Nanomedicine Titania nanotubes Strontium Osseointegration In vivo |
| title | In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating |
| title_full | In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating |
| title_fullStr | In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating |
| title_full_unstemmed | In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating |
| title_short | In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating |
| title_sort | in vivo osseointegration of ti implants with a strontium containing nanotubular coating |
| topic | Titania nanotubes Strontium Osseointegration In vivo |
| url | https://www.dovepress.com/in-vivo-osseointegration-of-ti-implants-with-a-strontium-containing-na-peer-reviewed-article-IJN |
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