The nanocomposite system comprising folic acid-modified graphene quantum dots loaded with evodiamine in the treatment of oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors in the world. At present, drugs are one of the most indispensable means to treat OSCC. Evodiamine (EVO) is one of the major bioactive compounds of the plant Evodia and has been shown to inhibit the growth of OSCC cells. H...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522004609 |
| _version_ | 1818194633900949504 |
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| author | Yu Ma Yan Liu Yurui Wang Yanzhu Guo Yuanyuan Li Ruizhi Li Xinzi Kong Qize Han Rong Wei Jing Wang |
| author_facet | Yu Ma Yan Liu Yurui Wang Yanzhu Guo Yuanyuan Li Ruizhi Li Xinzi Kong Qize Han Rong Wei Jing Wang |
| author_sort | Yu Ma |
| collection | DOAJ |
| description | Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors in the world. At present, drugs are one of the most indispensable means to treat OSCC. Evodiamine (EVO) is one of the major bioactive compounds of the plant Evodia and has been shown to inhibit the growth of OSCC cells. However, it suffers from poor aqueous solubility, which results in a low bioavailability. To improve of this property, we utilized graphene quantum dots (GQDs) as a vehicle for the delivery of EVO, which were functionalized with folic acid (FA) for targeting the tumor cells. The GQDs-FA-EVO nanocomposite system was synthesized by a self-assembly method, which was simulated theoretically at the atomic scale using molecular dynamics calculations. These MD simulations confirmed that the binding of EVO to the FA-functionalized GQDS was spontaneous and resulted in the formation of a highly stable nanocomposite complex. When the loading of EVO into the composite system was 10%, the growth inhibition rate of OSCC cells exceeded 50%(p < 0.01). In tumor-bearing nude mice, the GQDs-FA-EVO composite loaded with 10% EVO significantly reduced the tumor volume by 19% compared to the EVO group after the 18-days treatment(p < 0.05). |
| first_indexed | 2024-12-12T01:05:24Z |
| format | Article |
| id | doaj.art-6d7bf9c9d38d4de0b79f269ae22f4005 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-12-12T01:05:24Z |
| publishDate | 2022-08-01 |
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| spelling | doaj.art-6d7bf9c9d38d4de0b79f269ae22f40052022-12-22T00:43:35ZengElsevierMaterials & Design0264-12752022-08-01220110838The nanocomposite system comprising folic acid-modified graphene quantum dots loaded with evodiamine in the treatment of oral squamous cell carcinomaYu Ma0Yan Liu1Yurui Wang2Yanzhu Guo3Yuanyuan Li4Ruizhi Li5Xinzi Kong6Qize Han7Rong Wei8Jing Wang9School/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, PR China; Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, Lanzhou University, Lanzhou 730000, PR China; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA; Corresponding authors at: School/Hospital of Stomatology, Lanzhou University Lanzhou 730000, PR China.School/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, PR ChinaSchool/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, PR ChinaSchool/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, PR ChinaSchool/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, PR ChinaSchool/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, PR ChinaSchool/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, PR ChinaSchool/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, PR ChinaSchool/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, PR China; Corresponding authors at: School/Hospital of Stomatology, Lanzhou University Lanzhou 730000, PR China.School/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, PR China; Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, Lanzhou University, Lanzhou 730000, PR China; Clinical Research Center for Oral Diseases, Lanzhou University, Lanzhou 730000, PR China; Clinical Research Center of Shanxi Province for Dental and Maxillofacial Diseases College of Stomatology, Xi’an Jiaotong University, PR China; Corresponding authors at: School/Hospital of Stomatology, Lanzhou University Lanzhou 730000, PR China.Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors in the world. At present, drugs are one of the most indispensable means to treat OSCC. Evodiamine (EVO) is one of the major bioactive compounds of the plant Evodia and has been shown to inhibit the growth of OSCC cells. However, it suffers from poor aqueous solubility, which results in a low bioavailability. To improve of this property, we utilized graphene quantum dots (GQDs) as a vehicle for the delivery of EVO, which were functionalized with folic acid (FA) for targeting the tumor cells. The GQDs-FA-EVO nanocomposite system was synthesized by a self-assembly method, which was simulated theoretically at the atomic scale using molecular dynamics calculations. These MD simulations confirmed that the binding of EVO to the FA-functionalized GQDS was spontaneous and resulted in the formation of a highly stable nanocomposite complex. When the loading of EVO into the composite system was 10%, the growth inhibition rate of OSCC cells exceeded 50%(p < 0.01). In tumor-bearing nude mice, the GQDs-FA-EVO composite loaded with 10% EVO significantly reduced the tumor volume by 19% compared to the EVO group after the 18-days treatment(p < 0.05).http://www.sciencedirect.com/science/article/pii/S0264127522004609Graphene quantum dotsBioimagingEvodiamineTargeted drug delivery oralSquamous cell carcinoma |
| spellingShingle | Yu Ma Yan Liu Yurui Wang Yanzhu Guo Yuanyuan Li Ruizhi Li Xinzi Kong Qize Han Rong Wei Jing Wang The nanocomposite system comprising folic acid-modified graphene quantum dots loaded with evodiamine in the treatment of oral squamous cell carcinoma Materials & Design Graphene quantum dots Bioimaging Evodiamine Targeted drug delivery oral Squamous cell carcinoma |
| title | The nanocomposite system comprising folic acid-modified graphene quantum dots loaded with evodiamine in the treatment of oral squamous cell carcinoma |
| title_full | The nanocomposite system comprising folic acid-modified graphene quantum dots loaded with evodiamine in the treatment of oral squamous cell carcinoma |
| title_fullStr | The nanocomposite system comprising folic acid-modified graphene quantum dots loaded with evodiamine in the treatment of oral squamous cell carcinoma |
| title_full_unstemmed | The nanocomposite system comprising folic acid-modified graphene quantum dots loaded with evodiamine in the treatment of oral squamous cell carcinoma |
| title_short | The nanocomposite system comprising folic acid-modified graphene quantum dots loaded with evodiamine in the treatment of oral squamous cell carcinoma |
| title_sort | nanocomposite system comprising folic acid modified graphene quantum dots loaded with evodiamine in the treatment of oral squamous cell carcinoma |
| topic | Graphene quantum dots Bioimaging Evodiamine Targeted drug delivery oral Squamous cell carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522004609 |
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