Correlation between nucleated red blood cells and pulse oxygen saturation in neonatal asphyxia
Background Neonatal asphyxia is the major cause of neonatal death at a rate of approximately 23%. The incidence of asphyxia is higher in developing countries, due to limited availability of perinatology facilities. Hypoxia due to asphyxia is characterized by low pulse oxygen saturation (Sp02), which...
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2014-12-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1232 |
| _version_ | 1818615924534542336 |
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| author | Gatot Irawan Sarosa Farid A. Rahmadi Muhammad Sholeh Kosim Kamilah B. Rahardjani |
| author_facet | Gatot Irawan Sarosa Farid A. Rahmadi Muhammad Sholeh Kosim Kamilah B. Rahardjani |
| author_sort | Gatot Irawan Sarosa |
| collection | DOAJ |
| description | Background Neonatal asphyxia is the major cause of neonatal
death at a rate of approximately 23%. The incidence of asphyxia
is higher in developing countries, due to limited availability of
perinatology facilities. Hypoxia due to asphyxia is characterized
by low pulse oxygen saturation (Sp02), which basic health care
facilities are unable to monitor. The number ofnucleated red blood
cells (nRBCs) in asphyxia increases in order to compensate for
the hypoxia. Few studies have reported on nRBCs as they relate
to pulse oxygen saturation in neonatal asphyxia.
Objective To assess for a correlation between nRBCs and pulse
oxygen saturation in neonatal asphyxia.
Methods In this cross-sectional study, asphyxia was assessed by
way of Apgar scores; pulse oxygen saturation was monitored by
pulse oximetry; and nRBCs were determined by blood smears.
Statistical analysis used was Spearman's test.
Results Subjects were 41 neonates with asphyxia, 15 of whom
had 5th minute Apgar scores S 6. Subjects with Apgar scores S 6
had significantly higher umbilical venous nRBC counts [20.0 (SD
13.09) /100 white blood cell] than subjects with Apgar score >
6 [8.81 (SD 8.71) /100 white blood cell] ; (P = 0.004). Subjects
with Apgar S 6 had significantly lower 5th minute Sp02 values
[76.46 (SD 6.17) %] than subjects with Apgar scores > 6 [87.03
(SD 6.29)]; (P < 0.0001). Spearmans' test revealed a significant
correlation between higher nRBC counts and lower pulse oxygen
saturation (r = -0.804; P<0.0001) .
Conclusion In asphyxia neonatorum there is a correlation
between umbilical vein nRBC counts and the 5th minute Sp02.
As such, we recommend using nRBC examinations to predict
pulse oxygen saturation as a means to assess the severity of
hypoxia in peripheral areas where pulse oximetry machines may
be unavailable |
| first_indexed | 2024-12-16T16:41:38Z |
| format | Article |
| id | doaj.art-6d7dc67cbf7f4fbab4b842b233ef6b10 |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-16T16:41:38Z |
| publishDate | 2014-12-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-6d7dc67cbf7f4fbab4b842b233ef6b102022-12-21T22:24:18ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2014-12-01546314710.14238/pi54.6.2014.314-7977Correlation between nucleated red blood cells and pulse oxygen saturation in neonatal asphyxiaGatot Irawan Sarosa0Farid A. Rahmadi1Muhammad Sholeh Kosim2Kamilah B. Rahardjani3Department of Child Health, Diponegoro University Medical School/Dr. Kariadi HospitalDepartment of Child Health, Diponegoro University Medical School/Dr. Kariadi HospitalDepartment of Child Health, Diponegoro University Medical School/Dr. Kariadi HospitalDepartment of Child Health, Diponegoro University Medical School/Dr. Kariadi HospitalBackground Neonatal asphyxia is the major cause of neonatal death at a rate of approximately 23%. The incidence of asphyxia is higher in developing countries, due to limited availability of perinatology facilities. Hypoxia due to asphyxia is characterized by low pulse oxygen saturation (Sp02), which basic health care facilities are unable to monitor. The number ofnucleated red blood cells (nRBCs) in asphyxia increases in order to compensate for the hypoxia. Few studies have reported on nRBCs as they relate to pulse oxygen saturation in neonatal asphyxia. Objective To assess for a correlation between nRBCs and pulse oxygen saturation in neonatal asphyxia. Methods In this cross-sectional study, asphyxia was assessed by way of Apgar scores; pulse oxygen saturation was monitored by pulse oximetry; and nRBCs were determined by blood smears. Statistical analysis used was Spearman's test. Results Subjects were 41 neonates with asphyxia, 15 of whom had 5th minute Apgar scores S 6. Subjects with Apgar scores S 6 had significantly higher umbilical venous nRBC counts [20.0 (SD 13.09) /100 white blood cell] than subjects with Apgar score > 6 [8.81 (SD 8.71) /100 white blood cell] ; (P = 0.004). Subjects with Apgar S 6 had significantly lower 5th minute Sp02 values [76.46 (SD 6.17) %] than subjects with Apgar scores > 6 [87.03 (SD 6.29)]; (P < 0.0001). Spearmans' test revealed a significant correlation between higher nRBC counts and lower pulse oxygen saturation (r = -0.804; P<0.0001) . Conclusion In asphyxia neonatorum there is a correlation between umbilical vein nRBC counts and the 5th minute Sp02. As such, we recommend using nRBC examinations to predict pulse oxygen saturation as a means to assess the severity of hypoxia in peripheral areas where pulse oximetry machines may be unavailablehttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1232nRBC, pulse oxygen saturation, asphyxia |
| spellingShingle | Gatot Irawan Sarosa Farid A. Rahmadi Muhammad Sholeh Kosim Kamilah B. Rahardjani Correlation between nucleated red blood cells and pulse oxygen saturation in neonatal asphyxia Paediatrica Indonesiana nRBC, pulse oxygen saturation, asphyxia |
| title | Correlation between nucleated red blood cells and pulse oxygen saturation in neonatal asphyxia |
| title_full | Correlation between nucleated red blood cells and pulse oxygen saturation in neonatal asphyxia |
| title_fullStr | Correlation between nucleated red blood cells and pulse oxygen saturation in neonatal asphyxia |
| title_full_unstemmed | Correlation between nucleated red blood cells and pulse oxygen saturation in neonatal asphyxia |
| title_short | Correlation between nucleated red blood cells and pulse oxygen saturation in neonatal asphyxia |
| title_sort | correlation between nucleated red blood cells and pulse oxygen saturation in neonatal asphyxia |
| topic | nRBC, pulse oxygen saturation, asphyxia |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1232 |
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