A novel approach to low-cost, rapid and simultaneous colorimetric detection of multiple analytes using 3D printed microfluidic channels
This research paper presents an inventive technique to swiftly create microfluidic channels on distinct membrane papers, enabling colorimetric drug detection. Using a modified DIY RepRap 3D printer with a syringe pump, microfluidic channels (µPADs) are crafted on a flexible nylon-based substrate. Th...
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| Format: | Article |
| Language: | English |
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The Royal Society
2024-01-01
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| Series: | Royal Society Open Science |
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| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsos.231168 |
| _version_ | 1827572331041521664 |
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| author | Piyush Mishra Sagar Navariya Priyanshi Gupta Bhupendra Pratap Singh Samridhi Chopra Swapnil Shrivastava Ved Varun Agrawal |
| author_facet | Piyush Mishra Sagar Navariya Priyanshi Gupta Bhupendra Pratap Singh Samridhi Chopra Swapnil Shrivastava Ved Varun Agrawal |
| author_sort | Piyush Mishra |
| collection | DOAJ |
| description | This research paper presents an inventive technique to swiftly create microfluidic channels on distinct membrane papers, enabling colorimetric drug detection. Using a modified DIY RepRap 3D printer with a syringe pump, microfluidic channels (µPADs) are crafted on a flexible nylon-based substrate. This allows simultaneous detection of four common drugs with a single reagent. An optimized blend of polydimethylsiloxane (PDMS) dissolved in hexane is used to create hydrophobic channels on various filter papers. The PDMS-hexane mixture infiltrates the paper's pores, forming hydrophobic barriers that confine liquids within the channels. These barriers are cured on the printer's hot plate, controlling channel width and preventing spreading. Capillary action drives fluid along these paths without spreading. This novel approach provides a versatile solution for rapid microfluidic channel creation on membrane papers. The DIY RepRap 3D printer integration offers precise control and faster curing. The PDMS-hexane solution accurately forms hydrophobic barriers, containing liquids within desired channels. The resulting microfluidic system holds potential for portable, cost-effective drug detection and various sensing applications. |
| first_indexed | 2024-03-08T13:34:22Z |
| format | Article |
| id | doaj.art-6d815678ea244230ac186d9ed9c069e6 |
| institution | Directory Open Access Journal |
| issn | 2054-5703 |
| language | English |
| last_indexed | 2024-04-24T16:29:16Z |
| publishDate | 2024-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj.art-6d815678ea244230ac186d9ed9c069e62024-03-30T08:51:41ZengThe Royal SocietyRoyal Society Open Science2054-57032024-01-0111110.1098/rsos.231168A novel approach to low-cost, rapid and simultaneous colorimetric detection of multiple analytes using 3D printed microfluidic channelsPiyush Mishra0Sagar Navariya1Priyanshi Gupta2Bhupendra Pratap Singh3Samridhi Chopra4Swapnil Shrivastava5Ved Varun Agrawal6CSIR-National Physical Laboratory, Dr. K.S. Krishnan Marg, New Delhi 110012, IndiaCSIR-National Physical Laboratory, Dr. K.S. Krishnan Marg, New Delhi 110012, IndiaCSIR-National Physical Laboratory, Dr. K.S. Krishnan Marg, New Delhi 110012, IndiaLiquid Crystal Research Laboratory, Department of Physics, University of Lucknow, Lucknow 226007, IndiaCSIR-National Physical Laboratory, Dr. K.S. Krishnan Marg, New Delhi 110012, IndiaCSIR-National Physical Laboratory, Dr. K.S. Krishnan Marg, New Delhi 110012, IndiaCSIR-National Physical Laboratory, Dr. K.S. Krishnan Marg, New Delhi 110012, IndiaThis research paper presents an inventive technique to swiftly create microfluidic channels on distinct membrane papers, enabling colorimetric drug detection. Using a modified DIY RepRap 3D printer with a syringe pump, microfluidic channels (µPADs) are crafted on a flexible nylon-based substrate. This allows simultaneous detection of four common drugs with a single reagent. An optimized blend of polydimethylsiloxane (PDMS) dissolved in hexane is used to create hydrophobic channels on various filter papers. The PDMS-hexane mixture infiltrates the paper's pores, forming hydrophobic barriers that confine liquids within the channels. These barriers are cured on the printer's hot plate, controlling channel width and preventing spreading. Capillary action drives fluid along these paths without spreading. This novel approach provides a versatile solution for rapid microfluidic channel creation on membrane papers. The DIY RepRap 3D printer integration offers precise control and faster curing. The PDMS-hexane solution accurately forms hydrophobic barriers, containing liquids within desired channels. The resulting microfluidic system holds potential for portable, cost-effective drug detection and various sensing applications.https://royalsocietypublishing.org/doi/10.1098/rsos.231168colorimetric detectiondrug detectionDIY RepRap 3D printerμPADs |
| spellingShingle | Piyush Mishra Sagar Navariya Priyanshi Gupta Bhupendra Pratap Singh Samridhi Chopra Swapnil Shrivastava Ved Varun Agrawal A novel approach to low-cost, rapid and simultaneous colorimetric detection of multiple analytes using 3D printed microfluidic channels Royal Society Open Science colorimetric detection drug detection DIY RepRap 3D printer μPADs |
| title | A novel approach to low-cost, rapid and simultaneous colorimetric detection of multiple analytes using 3D printed microfluidic channels |
| title_full | A novel approach to low-cost, rapid and simultaneous colorimetric detection of multiple analytes using 3D printed microfluidic channels |
| title_fullStr | A novel approach to low-cost, rapid and simultaneous colorimetric detection of multiple analytes using 3D printed microfluidic channels |
| title_full_unstemmed | A novel approach to low-cost, rapid and simultaneous colorimetric detection of multiple analytes using 3D printed microfluidic channels |
| title_short | A novel approach to low-cost, rapid and simultaneous colorimetric detection of multiple analytes using 3D printed microfluidic channels |
| title_sort | novel approach to low cost rapid and simultaneous colorimetric detection of multiple analytes using 3d printed microfluidic channels |
| topic | colorimetric detection drug detection DIY RepRap 3D printer μPADs |
| url | https://royalsocietypublishing.org/doi/10.1098/rsos.231168 |
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