Microbiome analysis reveals gut microbiota alteration of early-weaned Yimeng black goats with the effect of milk replacer and age
Abstract Background Colonization of intestinal microbiota in ruminant during the early life is important to host health, metabolism and immunity. Accumulating evidence revealed the ameliorative effect of milk replacer administration in the gut microbial development of early-weaned ruminants. Yimeng...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Microbial Cell Factories |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12934-021-01568-5 |
| _version_ | 1830481574059048960 |
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| author | Aoyun Li Yan Yang Songkang Qin Shenjin Lv Taihua Jin Kun Li Zhaoqing Han Yongzhu Li |
| author_facet | Aoyun Li Yan Yang Songkang Qin Shenjin Lv Taihua Jin Kun Li Zhaoqing Han Yongzhu Li |
| author_sort | Aoyun Li |
| collection | DOAJ |
| description | Abstract Background Colonization of intestinal microbiota in ruminant during the early life is important to host health, metabolism and immunity. Accumulating evidence revealed the ameliorative effect of milk replacer administration in the gut microbial development of early-weaned ruminants. Yimeng black goats (YBGs) inhabiting Shandong, China show a complex intestinal microbial ecosystem, but studies of their gut microbiota are still insufficient to report. Here, this study was performed to investigate how the gut microbiota develops in weaned YBGs with the effect of age and milk replacer. Results Results indicated that both age and milk replacer were important factors to change the gut microbiota of YBGs. Although the alpha diversity of gut microbiota did not change with the age of YBGs, the taxonomic compositions significantly changed. The relative abundance of some beneficial bacteria such as Lachnospiraceae, Ruminococcaceae, Ruminiclostridium, Eubacterium and Barnesiella significantly decreased and subsequently increase with age, which contributes to maintain the stability of intestinal environment and realize the diversity of intestinal functions. The relative abundance of Porphyromonas, Brevundimonas, Flavobacterium, Stenotrophomonas, Propionibacterium, Acinetobacter, Enterococcus and Clostridium belong to pathogenic bacteria in milk replacer-treated YBGs was significantly decreased. Additionally, some beneficial bacteria such as Ruminococcus, Ruminococcaceae, Christensenellaceae and Ruminiclostridium also display a trend of decreasing first followed by gradually increasing. Conclusions This study first revealed the gut bacterial community alterations in YBGs with the effect of age and milk replacer. This study also characterized the gut microbial distribution in YBGs with different ages and provided better insight into microbial population structure and diversity of YBGs. Moreover, milk replacer may serve as a good applicant for improving gut microbial development in early-weaned YBGs. |
| first_indexed | 2024-12-21T17:21:32Z |
| format | Article |
| id | doaj.art-6d82097193184ddc81cb320042460343 |
| institution | Directory Open Access Journal |
| issn | 1475-2859 |
| language | English |
| last_indexed | 2024-12-21T17:21:32Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Microbial Cell Factories |
| spelling | doaj.art-6d82097193184ddc81cb3200424603432022-12-21T18:56:09ZengBMCMicrobial Cell Factories1475-28592021-03-0120111410.1186/s12934-021-01568-5Microbiome analysis reveals gut microbiota alteration of early-weaned Yimeng black goats with the effect of milk replacer and ageAoyun Li0Yan Yang1Songkang Qin2Shenjin Lv3Taihua Jin4Kun Li5Zhaoqing Han6Yongzhu Li7College of Agriculture and Forestry Science, Linyi UniversityLinyi Academy of Agricultural SciencesCollege of Veterinary Medicine, Huazhong Agricultural UniversityCollege of Agriculture and Forestry Science, Linyi UniversityCollege of Agriculture and Forestry Science, Linyi UniversityInstitute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural UniversityCollege of Agriculture and Forestry Science, Linyi UniversityCollege of Agriculture and Forestry Science, Linyi UniversityAbstract Background Colonization of intestinal microbiota in ruminant during the early life is important to host health, metabolism and immunity. Accumulating evidence revealed the ameliorative effect of milk replacer administration in the gut microbial development of early-weaned ruminants. Yimeng black goats (YBGs) inhabiting Shandong, China show a complex intestinal microbial ecosystem, but studies of their gut microbiota are still insufficient to report. Here, this study was performed to investigate how the gut microbiota develops in weaned YBGs with the effect of age and milk replacer. Results Results indicated that both age and milk replacer were important factors to change the gut microbiota of YBGs. Although the alpha diversity of gut microbiota did not change with the age of YBGs, the taxonomic compositions significantly changed. The relative abundance of some beneficial bacteria such as Lachnospiraceae, Ruminococcaceae, Ruminiclostridium, Eubacterium and Barnesiella significantly decreased and subsequently increase with age, which contributes to maintain the stability of intestinal environment and realize the diversity of intestinal functions. The relative abundance of Porphyromonas, Brevundimonas, Flavobacterium, Stenotrophomonas, Propionibacterium, Acinetobacter, Enterococcus and Clostridium belong to pathogenic bacteria in milk replacer-treated YBGs was significantly decreased. Additionally, some beneficial bacteria such as Ruminococcus, Ruminococcaceae, Christensenellaceae and Ruminiclostridium also display a trend of decreasing first followed by gradually increasing. Conclusions This study first revealed the gut bacterial community alterations in YBGs with the effect of age and milk replacer. This study also characterized the gut microbial distribution in YBGs with different ages and provided better insight into microbial population structure and diversity of YBGs. Moreover, milk replacer may serve as a good applicant for improving gut microbial development in early-weaned YBGs.https://doi.org/10.1186/s12934-021-01568-5Milk replacerGut microbiotaYimeng black goatsWeanedAge |
| spellingShingle | Aoyun Li Yan Yang Songkang Qin Shenjin Lv Taihua Jin Kun Li Zhaoqing Han Yongzhu Li Microbiome analysis reveals gut microbiota alteration of early-weaned Yimeng black goats with the effect of milk replacer and age Microbial Cell Factories Milk replacer Gut microbiota Yimeng black goats Weaned Age |
| title | Microbiome analysis reveals gut microbiota alteration of early-weaned Yimeng black goats with the effect of milk replacer and age |
| title_full | Microbiome analysis reveals gut microbiota alteration of early-weaned Yimeng black goats with the effect of milk replacer and age |
| title_fullStr | Microbiome analysis reveals gut microbiota alteration of early-weaned Yimeng black goats with the effect of milk replacer and age |
| title_full_unstemmed | Microbiome analysis reveals gut microbiota alteration of early-weaned Yimeng black goats with the effect of milk replacer and age |
| title_short | Microbiome analysis reveals gut microbiota alteration of early-weaned Yimeng black goats with the effect of milk replacer and age |
| title_sort | microbiome analysis reveals gut microbiota alteration of early weaned yimeng black goats with the effect of milk replacer and age |
| topic | Milk replacer Gut microbiota Yimeng black goats Weaned Age |
| url | https://doi.org/10.1186/s12934-021-01568-5 |
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