Metabolic Pathways in Breast Cancer Reprograming: An Insight to Non-Coding RNAs
Cancer cells reprogram their metabolisms to achieve high energetic requirements and produce precursors that facilitate uncontrolled cell proliferation. Metabolic reprograming involves not only the dysregulation in glucose-metabolizing regulatory enzymes, but also the enzymes engaging in the lipid an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/19/2973 |
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| author | Fereydoon Abedi-Gaballu Elham Kamal Kazemi Seyed Ahmad Salehzadeh Behnaz Mansoori Farhad Eslami Ali Emami Gholamreza Dehghan Behzad Baradaran Behzad Mansoori William C. Cho |
| author_facet | Fereydoon Abedi-Gaballu Elham Kamal Kazemi Seyed Ahmad Salehzadeh Behnaz Mansoori Farhad Eslami Ali Emami Gholamreza Dehghan Behzad Baradaran Behzad Mansoori William C. Cho |
| author_sort | Fereydoon Abedi-Gaballu |
| collection | DOAJ |
| description | Cancer cells reprogram their metabolisms to achieve high energetic requirements and produce precursors that facilitate uncontrolled cell proliferation. Metabolic reprograming involves not only the dysregulation in glucose-metabolizing regulatory enzymes, but also the enzymes engaging in the lipid and amino acid metabolisms. Nevertheless, the underlying regulatory mechanisms of reprograming are not fully understood. Non-coding RNAs (ncRNAs) as functional RNA molecules cannot translate into proteins, but they do play a regulatory role in gene expression. Moreover, ncRNAs have been demonstrated to be implicated in the metabolic modulations in breast cancer (BC) by regulating the metabolic-related enzymes. Here, we will focus on the regulatory involvement of <i>ncRNAs </i>(<i>microRNA, circular RNA and long ncRNA</i>) in BC metabolism, including glucose, lipid and glutamine metabolism. Investigation of this aspect may not only alter the approaches of BC diagnosis and prognosis, but may also open a new avenue in using ncRNA-based therapeutics for BC treatment by targeting different metabolic pathways. |
| first_indexed | 2024-03-09T21:54:50Z |
| format | Article |
| id | doaj.art-6d820d291fcc4330b5a38fe5a97f36cf |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T21:54:50Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6d820d291fcc4330b5a38fe5a97f36cf2023-11-23T20:00:25ZengMDPI AGCells2073-44092022-09-011119297310.3390/cells11192973Metabolic Pathways in Breast Cancer Reprograming: An Insight to Non-Coding RNAsFereydoon Abedi-Gaballu0Elham Kamal Kazemi1Seyed Ahmad Salehzadeh2Behnaz Mansoori3Farhad Eslami4Ali Emami5Gholamreza Dehghan6Behzad Baradaran7Behzad Mansoori8William C. Cho9Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 51666-14731, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz 51666-14731, IranDepartment of Medicinal Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 175-14115, IranDepartment of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran 175-14115, IranDepartment of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz 51666-16471, IranDepartment of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz 51666-16471, IranDepartment of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz 51666-16471, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz 51666-14731, IranCellular and Molecular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104, USADepartment of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, ChinaCancer cells reprogram their metabolisms to achieve high energetic requirements and produce precursors that facilitate uncontrolled cell proliferation. Metabolic reprograming involves not only the dysregulation in glucose-metabolizing regulatory enzymes, but also the enzymes engaging in the lipid and amino acid metabolisms. Nevertheless, the underlying regulatory mechanisms of reprograming are not fully understood. Non-coding RNAs (ncRNAs) as functional RNA molecules cannot translate into proteins, but they do play a regulatory role in gene expression. Moreover, ncRNAs have been demonstrated to be implicated in the metabolic modulations in breast cancer (BC) by regulating the metabolic-related enzymes. Here, we will focus on the regulatory involvement of <i>ncRNAs </i>(<i>microRNA, circular RNA and long ncRNA</i>) in BC metabolism, including glucose, lipid and glutamine metabolism. Investigation of this aspect may not only alter the approaches of BC diagnosis and prognosis, but may also open a new avenue in using ncRNA-based therapeutics for BC treatment by targeting different metabolic pathways.https://www.mdpi.com/2073-4409/11/19/2973breast cancerreprogramingnon-coding RNAmetabolic pathways |
| spellingShingle | Fereydoon Abedi-Gaballu Elham Kamal Kazemi Seyed Ahmad Salehzadeh Behnaz Mansoori Farhad Eslami Ali Emami Gholamreza Dehghan Behzad Baradaran Behzad Mansoori William C. Cho Metabolic Pathways in Breast Cancer Reprograming: An Insight to Non-Coding RNAs Cells breast cancer reprograming non-coding RNA metabolic pathways |
| title | Metabolic Pathways in Breast Cancer Reprograming: An Insight to Non-Coding RNAs |
| title_full | Metabolic Pathways in Breast Cancer Reprograming: An Insight to Non-Coding RNAs |
| title_fullStr | Metabolic Pathways in Breast Cancer Reprograming: An Insight to Non-Coding RNAs |
| title_full_unstemmed | Metabolic Pathways in Breast Cancer Reprograming: An Insight to Non-Coding RNAs |
| title_short | Metabolic Pathways in Breast Cancer Reprograming: An Insight to Non-Coding RNAs |
| title_sort | metabolic pathways in breast cancer reprograming an insight to non coding rnas |
| topic | breast cancer reprograming non-coding RNA metabolic pathways |
| url | https://www.mdpi.com/2073-4409/11/19/2973 |
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