Bone Disorders in Pediatric Chronic Kidney Disease: A Literature Review
Intense changes in mineral and bone metabolism are frequent in chronic kidney disease (CKD) and represent an important cause of morbidity and reduced quality of life. These disorders have conventionally been defined as renal osteodystrophy and classified based on bone biopsy, but due to a lack of bo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/11/1395 |
| _version_ | 1797460120656936960 |
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| author | Lavinia Capossela Serena Ferretti Silvia D’Alonzo Lorenzo Di Sarno Valeria Pansini Antonietta Curatola Antonio Chiaretti Antonio Gatto |
| author_facet | Lavinia Capossela Serena Ferretti Silvia D’Alonzo Lorenzo Di Sarno Valeria Pansini Antonietta Curatola Antonio Chiaretti Antonio Gatto |
| author_sort | Lavinia Capossela |
| collection | DOAJ |
| description | Intense changes in mineral and bone metabolism are frequent in chronic kidney disease (CKD) and represent an important cause of morbidity and reduced quality of life. These disorders have conventionally been defined as renal osteodystrophy and classified based on bone biopsy, but due to a lack of bone biopsy data and validated radiological methods to evaluate bone morphology in children, it has been challenging to effectively assess renal osteodystrophy in pediatric CKD; the consequence has been the suboptimal management of bone disorders in children. CKD–mineral and bone disorder (CKD-MBD) is a new expression used to describe a systemic disorder of mineral and bone metabolism as a result of CKD. CKD-MBD is a triad of biochemical imbalances in calcium, phosphate, parathyroid hormone, and vitamin D; bone deformities and soft tissue calcification. This literature review aims to explore the pathogenesis, diagnostic approach, and treatment of CKD-MBD in children and the effects of renal osteodystrophy on growing skeleton, with a specific focus on the biological basis of this peculiar condition. |
| first_indexed | 2024-03-09T17:00:37Z |
| format | Article |
| id | doaj.art-6d85ad9932e04ef7919b1e6e6d0d464e |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T17:00:37Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-6d85ad9932e04ef7919b1e6e6d0d464e2023-11-24T14:30:13ZengMDPI AGBiology2079-77372023-11-011211139510.3390/biology12111395Bone Disorders in Pediatric Chronic Kidney Disease: A Literature ReviewLavinia Capossela0Serena Ferretti1Silvia D’Alonzo2Lorenzo Di Sarno3Valeria Pansini4Antonietta Curatola5Antonio Chiaretti6Antonio Gatto7Institute of Pediatrics, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica Sacro Cuore, 00168 Rome, ItalyInstitute of Pediatrics, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica Sacro Cuore, 00168 Rome, ItalyNephrology Unit, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, ItalyInstitute of Pediatrics, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica Sacro Cuore, 00168 Rome, ItalyInstitute of Pediatrics, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyInstitute of Pediatrics, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyInstitute of Pediatrics, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica Sacro Cuore, 00168 Rome, ItalyInstitute of Pediatrics, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyIntense changes in mineral and bone metabolism are frequent in chronic kidney disease (CKD) and represent an important cause of morbidity and reduced quality of life. These disorders have conventionally been defined as renal osteodystrophy and classified based on bone biopsy, but due to a lack of bone biopsy data and validated radiological methods to evaluate bone morphology in children, it has been challenging to effectively assess renal osteodystrophy in pediatric CKD; the consequence has been the suboptimal management of bone disorders in children. CKD–mineral and bone disorder (CKD-MBD) is a new expression used to describe a systemic disorder of mineral and bone metabolism as a result of CKD. CKD-MBD is a triad of biochemical imbalances in calcium, phosphate, parathyroid hormone, and vitamin D; bone deformities and soft tissue calcification. This literature review aims to explore the pathogenesis, diagnostic approach, and treatment of CKD-MBD in children and the effects of renal osteodystrophy on growing skeleton, with a specific focus on the biological basis of this peculiar condition.https://www.mdpi.com/2079-7737/12/11/1395bonediseaserenalchildrenosteodystrophy |
| spellingShingle | Lavinia Capossela Serena Ferretti Silvia D’Alonzo Lorenzo Di Sarno Valeria Pansini Antonietta Curatola Antonio Chiaretti Antonio Gatto Bone Disorders in Pediatric Chronic Kidney Disease: A Literature Review Biology bone disease renal children osteodystrophy |
| title | Bone Disorders in Pediatric Chronic Kidney Disease: A Literature Review |
| title_full | Bone Disorders in Pediatric Chronic Kidney Disease: A Literature Review |
| title_fullStr | Bone Disorders in Pediatric Chronic Kidney Disease: A Literature Review |
| title_full_unstemmed | Bone Disorders in Pediatric Chronic Kidney Disease: A Literature Review |
| title_short | Bone Disorders in Pediatric Chronic Kidney Disease: A Literature Review |
| title_sort | bone disorders in pediatric chronic kidney disease a literature review |
| topic | bone disease renal children osteodystrophy |
| url | https://www.mdpi.com/2079-7737/12/11/1395 |
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