Host–Bacterial Interactions: Outcomes of Antimicrobial Peptide Applications
The bacterial membrane is part of a secretion system which plays an integral role to secrete proteins responsible for cell viability and pathogenicity; pathogenic bacteria, for example, secrete virulence factors and other membrane-associated proteins to invade the host cells through various types of...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Membranes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0375/12/7/715 |
| _version_ | 1797433325401407488 |
|---|---|
| author | Asma Hussain Alkatheri Polly Soo-Xi Yap Aisha Abushelaibi Kok-Song Lai Wan-Hee Cheng Swee-Hua Erin Lim |
| author_facet | Asma Hussain Alkatheri Polly Soo-Xi Yap Aisha Abushelaibi Kok-Song Lai Wan-Hee Cheng Swee-Hua Erin Lim |
| author_sort | Asma Hussain Alkatheri |
| collection | DOAJ |
| description | The bacterial membrane is part of a secretion system which plays an integral role to secrete proteins responsible for cell viability and pathogenicity; pathogenic bacteria, for example, secrete virulence factors and other membrane-associated proteins to invade the host cells through various types of secretion systems (Type I to Type IX). The bacterial membrane can also mediate microbial communities’ communication through quorum sensing (QS), by secreting auto-stimulants to coordinate gene expression. QS plays an important role in regulating various physiological processes, including bacterial biofilm formation while providing increased virulence, subsequently leading to antimicrobial resistance. Multi-drug resistant (MDR) bacteria have emerged as a threat to global health, and various strategies targeting QS and biofilm formation have been explored by researchers worldwide. Since the bacterial secretion systems play such a crucial role in host–bacterial interactions, this review intends to outline current understanding of bacterial membrane systems, which may provide new insights for designing approaches aimed at antimicrobials discovery. Various mechanisms pertaining interaction of the bacterial membrane with host cells and antimicrobial agents will be highlighted, as well as the evolution of bacterial membranes in evasion of antimicrobial agents. Finally, the use of antimicrobial peptides (AMPs) as a cellular device for bacterial secretion systems will be discussed as emerging potential candidates for the treatment of multidrug resistance infections. |
| first_indexed | 2024-03-09T10:15:26Z |
| format | Article |
| id | doaj.art-6d8856fadadf42049a0c4388973f2354 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-09T10:15:26Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-6d8856fadadf42049a0c4388973f23542023-12-01T22:25:57ZengMDPI AGMembranes2077-03752022-07-0112771510.3390/membranes12070715Host–Bacterial Interactions: Outcomes of Antimicrobial Peptide ApplicationsAsma Hussain Alkatheri0Polly Soo-Xi Yap1Aisha Abushelaibi2Kok-Song Lai3Wan-Hee Cheng4Swee-Hua Erin Lim5Health Sciences Division, Abu Dhabi Women’s College, Higher Colleges of Technology, Abu Dhabi 41012, United Arab EmiratesJeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Darul Ehsan 47500, Selangor, MalaysiaOffice of Campus Director, Abu Dhabi Colleges, Higher Colleges of Technology, Abu Dhabi 41012, United Arab EmiratesHealth Sciences Division, Abu Dhabi Women’s College, Higher Colleges of Technology, Abu Dhabi 41012, United Arab EmiratesFaculty of Health and Life Sciences, INTI International University, Persiaran Perdana BBN, Nilai 71800, Negeri Sembilan, MalaysiaHealth Sciences Division, Abu Dhabi Women’s College, Higher Colleges of Technology, Abu Dhabi 41012, United Arab EmiratesThe bacterial membrane is part of a secretion system which plays an integral role to secrete proteins responsible for cell viability and pathogenicity; pathogenic bacteria, for example, secrete virulence factors and other membrane-associated proteins to invade the host cells through various types of secretion systems (Type I to Type IX). The bacterial membrane can also mediate microbial communities’ communication through quorum sensing (QS), by secreting auto-stimulants to coordinate gene expression. QS plays an important role in regulating various physiological processes, including bacterial biofilm formation while providing increased virulence, subsequently leading to antimicrobial resistance. Multi-drug resistant (MDR) bacteria have emerged as a threat to global health, and various strategies targeting QS and biofilm formation have been explored by researchers worldwide. Since the bacterial secretion systems play such a crucial role in host–bacterial interactions, this review intends to outline current understanding of bacterial membrane systems, which may provide new insights for designing approaches aimed at antimicrobials discovery. Various mechanisms pertaining interaction of the bacterial membrane with host cells and antimicrobial agents will be highlighted, as well as the evolution of bacterial membranes in evasion of antimicrobial agents. Finally, the use of antimicrobial peptides (AMPs) as a cellular device for bacterial secretion systems will be discussed as emerging potential candidates for the treatment of multidrug resistance infections.https://www.mdpi.com/2077-0375/12/7/715bacterial membranesecreting systemquorum sensingantimicrobial peptidesantimicrobial resistance |
| spellingShingle | Asma Hussain Alkatheri Polly Soo-Xi Yap Aisha Abushelaibi Kok-Song Lai Wan-Hee Cheng Swee-Hua Erin Lim Host–Bacterial Interactions: Outcomes of Antimicrobial Peptide Applications Membranes bacterial membrane secreting system quorum sensing antimicrobial peptides antimicrobial resistance |
| title | Host–Bacterial Interactions: Outcomes of Antimicrobial Peptide Applications |
| title_full | Host–Bacterial Interactions: Outcomes of Antimicrobial Peptide Applications |
| title_fullStr | Host–Bacterial Interactions: Outcomes of Antimicrobial Peptide Applications |
| title_full_unstemmed | Host–Bacterial Interactions: Outcomes of Antimicrobial Peptide Applications |
| title_short | Host–Bacterial Interactions: Outcomes of Antimicrobial Peptide Applications |
| title_sort | host bacterial interactions outcomes of antimicrobial peptide applications |
| topic | bacterial membrane secreting system quorum sensing antimicrobial peptides antimicrobial resistance |
| url | https://www.mdpi.com/2077-0375/12/7/715 |
| work_keys_str_mv | AT asmahussainalkatheri hostbacterialinteractionsoutcomesofantimicrobialpeptideapplications AT pollysooxiyap hostbacterialinteractionsoutcomesofantimicrobialpeptideapplications AT aishaabushelaibi hostbacterialinteractionsoutcomesofantimicrobialpeptideapplications AT koksonglai hostbacterialinteractionsoutcomesofantimicrobialpeptideapplications AT wanheecheng hostbacterialinteractionsoutcomesofantimicrobialpeptideapplications AT sweehuaerinlim hostbacterialinteractionsoutcomesofantimicrobialpeptideapplications |