Ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescents
Abstract Bilateral ovarian epithelial neoplasms in adolescents are rare. Moreover, borderline mucinous neoplasms with local intraepithelial carcinoma with anaplastic carcinoma are even more infrequent. Herein, we presented a single case (a 17-year-old female) with regular menstrual cycles and stomac...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-07-01
|
| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-022-01010-3 |
| _version_ | 1797964120713068544 |
|---|---|
| author | Mengqi Huang Qian Lv Jingyan Xie |
| author_facet | Mengqi Huang Qian Lv Jingyan Xie |
| author_sort | Mengqi Huang |
| collection | DOAJ |
| description | Abstract Bilateral ovarian epithelial neoplasms in adolescents are rare. Moreover, borderline mucinous neoplasms with local intraepithelial carcinoma with anaplastic carcinoma are even more infrequent. Herein, we presented a single case (a 17-year-old female) with regular menstrual cycles and stomach pain when eating who was diagnosed with a left ovarian tumor accompanied by mural nodules. The right ovarian cyst, the left ovary, and the fallopian tube were removed by surgery. Intraoperative diagnosis suggested a bilateral ovarian tumor with mural nodules, which include three different pathological types: sarcomatoid transformation, anaplastic carcinoma, and sarcoma. Paclitaxel combined with carboplatin was given for 6 cycles after an operation, and gonadotropin-releasing hormone agonist (GnRHa) was given at the beginning of chemotherapy for 3 cycles for ovarian function protection. Regular follow-up (the last follow-up was performed 48 months after the operation) of gynecological ultrasound and tumor indicators did not indicate recurrence. In clinical practice, it is necessary to pay attention to the symptoms such as abdominal pain in adolescent females. Routine non-invasive pelvic ultrasound is recommended to fully evaluate the nature of the tumor before surgery, and decide the operation mode. Also, intraoperative frozen pathology of the tissue should be performed as soon as possible. |
| first_indexed | 2024-04-11T01:39:07Z |
| format | Article |
| id | doaj.art-6d89a56aee4e4a9993d92a39ebbd05ff |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T01:39:07Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-6d89a56aee4e4a9993d92a39ebbd05ff2023-01-03T08:32:16ZengBMCJournal of Ovarian Research1757-22152022-07-011511610.1186/s13048-022-01010-3Ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescentsMengqi Huang0Qian Lv1Jingyan Xie2Departments of Gynecology, Nanjing First Hospital, Nanjing Medical UniversityDepartments of Pathology, Nanjing First Hospital, Nanjing Medical UniversityDepartments of Gynecology, Nanjing First Hospital, Nanjing Medical UniversityAbstract Bilateral ovarian epithelial neoplasms in adolescents are rare. Moreover, borderline mucinous neoplasms with local intraepithelial carcinoma with anaplastic carcinoma are even more infrequent. Herein, we presented a single case (a 17-year-old female) with regular menstrual cycles and stomach pain when eating who was diagnosed with a left ovarian tumor accompanied by mural nodules. The right ovarian cyst, the left ovary, and the fallopian tube were removed by surgery. Intraoperative diagnosis suggested a bilateral ovarian tumor with mural nodules, which include three different pathological types: sarcomatoid transformation, anaplastic carcinoma, and sarcoma. Paclitaxel combined with carboplatin was given for 6 cycles after an operation, and gonadotropin-releasing hormone agonist (GnRHa) was given at the beginning of chemotherapy for 3 cycles for ovarian function protection. Regular follow-up (the last follow-up was performed 48 months after the operation) of gynecological ultrasound and tumor indicators did not indicate recurrence. In clinical practice, it is necessary to pay attention to the symptoms such as abdominal pain in adolescent females. Routine non-invasive pelvic ultrasound is recommended to fully evaluate the nature of the tumor before surgery, and decide the operation mode. Also, intraoperative frozen pathology of the tissue should be performed as soon as possible.https://doi.org/10.1186/s13048-022-01010-3AdolescentOvarian tumorMural nodulePathological featuresTreatment and prognosis |
| spellingShingle | Mengqi Huang Qian Lv Jingyan Xie Ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescents Journal of Ovarian Research Adolescent Ovarian tumor Mural nodule Pathological features Treatment and prognosis |
| title | Ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescents |
| title_full | Ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescents |
| title_fullStr | Ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescents |
| title_full_unstemmed | Ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescents |
| title_short | Ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescents |
| title_sort | ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescents |
| topic | Adolescent Ovarian tumor Mural nodule Pathological features Treatment and prognosis |
| url | https://doi.org/10.1186/s13048-022-01010-3 |
| work_keys_str_mv | AT mengqihuang ovarianmucinousborderlinetumorwithanaplasticcarcinomatousnodulesinadolescents AT qianlv ovarianmucinousborderlinetumorwithanaplasticcarcinomatousnodulesinadolescents AT jingyanxie ovarianmucinousborderlinetumorwithanaplasticcarcinomatousnodulesinadolescents |