Effect of birth weight, exclusive breastfeeding and growth in infancy on fat mass and fat free mass indices in early adolescence: an analysis of the Entebbe Mother and Baby Study (EMaBs) cohort [version 2; peer review: 1 approved, 2 approved with reservations]
Background: There is limited data from Africa on the effect of pre- and post-natal growth and infant feeding on later body composition. This study's aim was to investigate the effect of birth weight, exclusive breastfeeding and infant growth on adolescent body composition, using data from a Uga...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2020-01-01
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| Series: | AAS Open Research |
| Online Access: | https://aasopenresearch.org/articles/2-11/v2 |
| _version_ | 1797766791361986560 |
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| author | Jonathan Nsamba Swaib A. Lule Benigna Namara Christopher Zziwa Hellen Akurut Lawrence Lubyayi Florence Akello Josephine Tumusiime Alison M. Elliott Emily L. Webb |
| author_facet | Jonathan Nsamba Swaib A. Lule Benigna Namara Christopher Zziwa Hellen Akurut Lawrence Lubyayi Florence Akello Josephine Tumusiime Alison M. Elliott Emily L. Webb |
| author_sort | Jonathan Nsamba |
| collection | DOAJ |
| description | Background: There is limited data from Africa on the effect of pre- and post-natal growth and infant feeding on later body composition. This study's aim was to investigate the effect of birth weight, exclusive breastfeeding and infant growth on adolescent body composition, using data from a Ugandan birth cohort. Methods: Data was collected prenatally from pregnant women and prospectively from their resulting live offspring. Data on body composition (fat mass index [FMI] and fat free mass index [FFMI]) was collected from 10- and 11-year olds. Linear regression was used to assess the effect of birth weight, exclusive breastfeeding and infant growth on FMI and FFMI, adjusting for confounders. Results: 177 adolescents with a median age of 10.1 years were included in analysis, with mean FMI 2.9 kg/m2 (standard deviation (SD) 1.2), mean FFMI 12.8 kg/m2 (SD 1.4) and mean birth weight 3.2 kg (SD 0.5). 90 (50.9%) were male and 110 (63.2%) were exclusively breastfeeding at six weeks of age. Birth weight was associated with FMI in adolescence (regression coefficient β= 0.66 per kg increase in birth weight, 95% confidence interval (CI) (0.04, 1.29), P=0.02), while exclusive breastfeeding (β= -0.43, 95% CI (-1.06, 0.19), P=0.12), growth 0-6 months (β= 0.24 95% CI (-0.43, 0.92), P=0.48) and growth 6-12 months (β= 0.61, 95% CI (-0.23, 1.46), P=0.11) were not associated with FMI among adolescents. Birth weight (β= 0.91, 95% CI (0.17, 1.65), P=0.01) was associated with FFMI in adolescence. Exclusive breastfeeding (β= 0.17, 95% CI (-0.60, 0.94), P=0.62), growth 0-6 months (β= 0.56, 95% CI (-0.20, 1.33), P= 0.10), and growth 6-12 months (β= -0.02, 95% CI (-1.02, 0.99), P=0.97) were not associated with FFMI. Conclusions: Birth weight predicted body composition parameters in Ugandan early adolescents, however, exclusive breastfeeding at six weeks of age and growth in infancy did not. |
| first_indexed | 2024-03-12T20:29:20Z |
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| spelling | doaj.art-6d8ac4a76ec84232bcc86d93cafea06f2023-08-02T00:11:36ZengF1000 Research LtdAAS Open Research2515-93212020-01-01210.12688/aasopenres.12947.214136Effect of birth weight, exclusive breastfeeding and growth in infancy on fat mass and fat free mass indices in early adolescence: an analysis of the Entebbe Mother and Baby Study (EMaBs) cohort [version 2; peer review: 1 approved, 2 approved with reservations]Jonathan Nsamba0Swaib A. Lule1Benigna Namara2Christopher Zziwa3Hellen Akurut4Lawrence Lubyayi5Florence Akello6Josephine Tumusiime7Alison M. Elliott8Emily L. Webb9Department of Population Health, London School of Hygiene and Tropical Medicine, London, Keppel Street, WC1E 7HT, UKDepartment of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UKImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, P.O. Box 49, Entebbe, Uganda, UgandaImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, P.O. Box 49, Entebbe, Uganda, UgandaImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, P.O. Box 49, Entebbe, Uganda, UgandaImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, P.O. Box 49, Entebbe, Uganda, UgandaImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, P.O. Box 49, Entebbe, Uganda, UgandaImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, P.O. Box 49, Entebbe, Uganda, UgandaImmunomodulation and Vaccines Programme, MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, P.O. Box 49, Entebbe, Uganda, UgandaDepartment of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UKBackground: There is limited data from Africa on the effect of pre- and post-natal growth and infant feeding on later body composition. This study's aim was to investigate the effect of birth weight, exclusive breastfeeding and infant growth on adolescent body composition, using data from a Ugandan birth cohort. Methods: Data was collected prenatally from pregnant women and prospectively from their resulting live offspring. Data on body composition (fat mass index [FMI] and fat free mass index [FFMI]) was collected from 10- and 11-year olds. Linear regression was used to assess the effect of birth weight, exclusive breastfeeding and infant growth on FMI and FFMI, adjusting for confounders. Results: 177 adolescents with a median age of 10.1 years were included in analysis, with mean FMI 2.9 kg/m2 (standard deviation (SD) 1.2), mean FFMI 12.8 kg/m2 (SD 1.4) and mean birth weight 3.2 kg (SD 0.5). 90 (50.9%) were male and 110 (63.2%) were exclusively breastfeeding at six weeks of age. Birth weight was associated with FMI in adolescence (regression coefficient β= 0.66 per kg increase in birth weight, 95% confidence interval (CI) (0.04, 1.29), P=0.02), while exclusive breastfeeding (β= -0.43, 95% CI (-1.06, 0.19), P=0.12), growth 0-6 months (β= 0.24 95% CI (-0.43, 0.92), P=0.48) and growth 6-12 months (β= 0.61, 95% CI (-0.23, 1.46), P=0.11) were not associated with FMI among adolescents. Birth weight (β= 0.91, 95% CI (0.17, 1.65), P=0.01) was associated with FFMI in adolescence. Exclusive breastfeeding (β= 0.17, 95% CI (-0.60, 0.94), P=0.62), growth 0-6 months (β= 0.56, 95% CI (-0.20, 1.33), P= 0.10), and growth 6-12 months (β= -0.02, 95% CI (-1.02, 0.99), P=0.97) were not associated with FFMI. Conclusions: Birth weight predicted body composition parameters in Ugandan early adolescents, however, exclusive breastfeeding at six weeks of age and growth in infancy did not.https://aasopenresearch.org/articles/2-11/v2 |
| spellingShingle | Jonathan Nsamba Swaib A. Lule Benigna Namara Christopher Zziwa Hellen Akurut Lawrence Lubyayi Florence Akello Josephine Tumusiime Alison M. Elliott Emily L. Webb Effect of birth weight, exclusive breastfeeding and growth in infancy on fat mass and fat free mass indices in early adolescence: an analysis of the Entebbe Mother and Baby Study (EMaBs) cohort [version 2; peer review: 1 approved, 2 approved with reservations] AAS Open Research |
| title | Effect of birth weight, exclusive breastfeeding and growth in infancy on fat mass and fat free mass indices in early adolescence: an analysis of the Entebbe Mother and Baby Study (EMaBs) cohort [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full | Effect of birth weight, exclusive breastfeeding and growth in infancy on fat mass and fat free mass indices in early adolescence: an analysis of the Entebbe Mother and Baby Study (EMaBs) cohort [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_fullStr | Effect of birth weight, exclusive breastfeeding and growth in infancy on fat mass and fat free mass indices in early adolescence: an analysis of the Entebbe Mother and Baby Study (EMaBs) cohort [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full_unstemmed | Effect of birth weight, exclusive breastfeeding and growth in infancy on fat mass and fat free mass indices in early adolescence: an analysis of the Entebbe Mother and Baby Study (EMaBs) cohort [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_short | Effect of birth weight, exclusive breastfeeding and growth in infancy on fat mass and fat free mass indices in early adolescence: an analysis of the Entebbe Mother and Baby Study (EMaBs) cohort [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_sort | effect of birth weight exclusive breastfeeding and growth in infancy on fat mass and fat free mass indices in early adolescence an analysis of the entebbe mother and baby study emabs cohort version 2 peer review 1 approved 2 approved with reservations |
| url | https://aasopenresearch.org/articles/2-11/v2 |
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