PD-L1 is upregulated by EBV-driven LMP1 through NF-κB pathway and correlates with poor prognosis in natural killer/T-cell lymphoma

PD-L1 is upregulated by EBV-driven LMP1 through NF-κB pathway and correlates with poor prognosis in natural killer/T-cell lymphoma

Abstract Background Natural killer/T-cell lymphoma (NKTCL) is an Epstein–Barr virus (EBV)-associated, highly aggressive lymphoma. Treatment outcome remains sub-optimal, especially for advanced-stage or relapsed diseases. Programmed cell death receptor 1 (PD-1) and PD ligand 1 (PD-L1) have become pro...

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Bibliographic Details
Main Authors: Xi-wen Bi, Hua Wang, Wen-wen Zhang, Jing-hua Wang, Wen-jian Liu, Zhong-jun Xia, Hui-qiang Huang, Wen-qi Jiang, Yu-jing Zhang, Liang Wang
Format: Article
Language:English
Published: BMC 2016-10-01
Series:Journal of Hematology & Oncology
Subjects:
Natural killer/T-cell lymphoma
Latent membrane protein 1
Epstein–Barr virus
Programmed cell death receptor 1
Online Access:http://link.springer.com/article/10.1186/s13045-016-0341-7

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