High miR-454-3p expression predicts poor prognosis in hepatocellular carcinoma
Yanqing Li,1 Yan Jiao,2 Zhuo Fu,3 Zhangping Luo,4 Jing Su,1 Yang Li11Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, People’s Republic of China; 2Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin Uni...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-04-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/high-mir-454-3p-expression-predicts-poor-prognosis-in-hepatocellular-c-peer-reviewed-article-CMAR |
| _version_ | 1818910492583788544 |
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| author | Li Y Jiao Y Fu Z Luo Z Su J Li Y |
| author_facet | Li Y Jiao Y Fu Z Luo Z Su J Li Y |
| author_sort | Li Y |
| collection | DOAJ |
| description | Yanqing Li,1 Yan Jiao,2 Zhuo Fu,3 Zhangping Luo,4 Jing Su,1 Yang Li11Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, People’s Republic of China; 2Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China; 3Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China; 4Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, People’s Republic of ChinaPurpose: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the clinic all over the world, which has become a public health challenge. The T/N/M staging system plays a core role in HCC prognosis. However, it cannot precisely stratify the risk of HCC prognosis. MiR-454-3p plays an important role in the progression of tumors. Therefore, we need to develop more reliable prognostic markers for HCC patients which can focus on miR-454-3p.Methods: We used Chi-square and Fisher exact tests to assess correlations between miR-454-3p expression and clinical parameters in liver cancer patients from The Cancer Genome Atlas database (TCGA). Then, Cox regression analysis, Kaplan-Meier curve, and log-rank test were used to compare the difference of survival between the high-expression group and low-expression group, and P value was included. Finally, we used TCGA data set to carry out gene enrichment analysis.Results: In this research, the expression of miR-454-3p increased in HCC and was associated with patient survival, G3/G4 staging, III/IV staging and T staging. Higher miR-454-3p expressed patients had shorter survival time. Besides, mitotic spindle, G2M checkpoint, and E2F targets were differentially enriched in miR-454-3p high-expression phenotype by Gene set enrichment analysis.Conclusion: Overexpression of miR-454-3p may be a significant and independent predictor of poor prognosis in HCC patients.Keywords: miR-454-3p, hepatocellular carcinoma (HCC), prognosis, predictor |
| first_indexed | 2024-12-19T22:43:40Z |
| format | Article |
| id | doaj.art-6d8bb2d529374022a747e064d271655e |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-19T22:43:40Z |
| publishDate | 2019-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-6d8bb2d529374022a747e064d271655e2022-12-21T20:03:00ZengDove Medical PressCancer Management and Research1179-13222019-04-01Volume 112795280244982High miR-454-3p expression predicts poor prognosis in hepatocellular carcinomaLi YJiao YFu ZLuo ZSu JLi YYanqing Li,1 Yan Jiao,2 Zhuo Fu,3 Zhangping Luo,4 Jing Su,1 Yang Li11Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, People’s Republic of China; 2Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China; 3Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China; 4Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, People’s Republic of ChinaPurpose: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the clinic all over the world, which has become a public health challenge. The T/N/M staging system plays a core role in HCC prognosis. However, it cannot precisely stratify the risk of HCC prognosis. MiR-454-3p plays an important role in the progression of tumors. Therefore, we need to develop more reliable prognostic markers for HCC patients which can focus on miR-454-3p.Methods: We used Chi-square and Fisher exact tests to assess correlations between miR-454-3p expression and clinical parameters in liver cancer patients from The Cancer Genome Atlas database (TCGA). Then, Cox regression analysis, Kaplan-Meier curve, and log-rank test were used to compare the difference of survival between the high-expression group and low-expression group, and P value was included. Finally, we used TCGA data set to carry out gene enrichment analysis.Results: In this research, the expression of miR-454-3p increased in HCC and was associated with patient survival, G3/G4 staging, III/IV staging and T staging. Higher miR-454-3p expressed patients had shorter survival time. Besides, mitotic spindle, G2M checkpoint, and E2F targets were differentially enriched in miR-454-3p high-expression phenotype by Gene set enrichment analysis.Conclusion: Overexpression of miR-454-3p may be a significant and independent predictor of poor prognosis in HCC patients.Keywords: miR-454-3p, hepatocellular carcinoma (HCC), prognosis, predictorhttps://www.dovepress.com/high-mir-454-3p-expression-predicts-poor-prognosis-in-hepatocellular-c-peer-reviewed-article-CMARmiR-454-3pHepatocellular carcinoma (HCC)prognosispredictor |
| spellingShingle | Li Y Jiao Y Fu Z Luo Z Su J Li Y High miR-454-3p expression predicts poor prognosis in hepatocellular carcinoma Cancer Management and Research miR-454-3p Hepatocellular carcinoma (HCC) prognosis predictor |
| title | High miR-454-3p expression predicts poor prognosis in hepatocellular carcinoma |
| title_full | High miR-454-3p expression predicts poor prognosis in hepatocellular carcinoma |
| title_fullStr | High miR-454-3p expression predicts poor prognosis in hepatocellular carcinoma |
| title_full_unstemmed | High miR-454-3p expression predicts poor prognosis in hepatocellular carcinoma |
| title_short | High miR-454-3p expression predicts poor prognosis in hepatocellular carcinoma |
| title_sort | high mir 454 3p expression predicts poor prognosis in hepatocellular carcinoma |
| topic | miR-454-3p Hepatocellular carcinoma (HCC) prognosis predictor |
| url | https://www.dovepress.com/high-mir-454-3p-expression-predicts-poor-prognosis-in-hepatocellular-c-peer-reviewed-article-CMAR |
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