Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation.

Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation.

Degradation of certain proteins through the ubiquitin-proteasome pathway is a common strategy taken by the key modulators responsible for stress responses. Kelch-like ECH-associated protein-1(Keap1), a substrate adaptor component of the Cullin3 (Cul3)-based ubiquitin E3 ligase complex, mediates the...

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Bibliographic Details
Main Authors: Zheng-Yu Jiang, Hong-Xi Chu, Mei-Yang Xi, Ting-Ting Yang, Jian-Min Jia, Jing-Jie Huang, Xiao-Ke Guo, Xiao-Jin Zhang, Qi-Dong You, Hao-Peng Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3774807?pdf=render

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