The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population
Abstract Background Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CRP in the healthy ageing population remained unclear, which was investig...
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| Format: | Article |
| Language: | English |
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BMC
2018-09-01
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| Series: | Immunity & Ageing |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12979-018-0126-7 |
| _version_ | 1818969870875754496 |
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| author | Ying Tang Peifen Liang Junzhe Chen Sha Fu Bo Liu Min Feng Baojuan Lin Ben Lee Anping Xu Hui Y. Lan |
| author_facet | Ying Tang Peifen Liang Junzhe Chen Sha Fu Bo Liu Min Feng Baojuan Lin Ben Lee Anping Xu Hui Y. Lan |
| author_sort | Ying Tang |
| collection | DOAJ |
| description | Abstract Background Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CRP in the healthy ageing population remained unclear, which was investigated in the present study. Methods Serum levels of high sensitive C-reactive protein (hs-CRP), glucose (Glu), triglyceride (TG), cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), superoxide dismutase (SOD), serum creatinine (SCr), serum uric acid (SUA) were measured in 6060healthy subjects (3672 male and 2388 female, mean age:45.9 years) who received routine physical examination at Sun Yat-sen Memorial Hospital, Guangzhou, China. Results In total of 6060 healthy people, serum levels of hs-CRP were significantly increased with ageing (P < 0.05), particularly in those with age over 45-year-old (1.31[0.69–2.75] vs 1.05[0.53–2.16]mg/L, P < 0.001). Interestingly, levels of serum hs-CRP were significantly higher in male than female population (1.24[0.65–2.57] vs 1.07[0.53–2.29]mg/L, P < 0.001). Correlation analysis also revealed that serum levels of hs-CRP positively correlated with age and SUA, but inversely correlated with serum levels of HDL-c and SOD (all P < 0.05). Conclusions Baseline levels of serum hs-CRP are increased with ageing and are significantly higher in male than female healthy population. In addition, elevated serum levels of hs-CRP are also associated with increased SUA but decreased HDL-c and SOD. Thus, serum levels of hs-CRP may be an indicator associated with ageing in healthy Chinese population. |
| first_indexed | 2024-12-20T14:27:28Z |
| format | Article |
| id | doaj.art-6d8c0f32797d45fd9bac503aacdce60b |
| institution | Directory Open Access Journal |
| issn | 1742-4933 |
| language | English |
| last_indexed | 2024-12-20T14:27:28Z |
| publishDate | 2018-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Immunity & Ageing |
| spelling | doaj.art-6d8c0f32797d45fd9bac503aacdce60b2022-12-21T19:37:44ZengBMCImmunity & Ageing1742-49332018-09-011511810.1186/s12979-018-0126-7The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy populationYing Tang0Peifen Liang1Junzhe Chen2Sha Fu3Bo Liu4Min Feng5Baojuan Lin6Ben Lee7Anping Xu8Hui Y. Lan9Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityGuangzhou Deling Software Technology Co., LtdDepartment of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Medicine and Therapeutics, Li KaShing Institute of Health Sciences, the Chinese University of Hong KongAbstract Background Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CRP in the healthy ageing population remained unclear, which was investigated in the present study. Methods Serum levels of high sensitive C-reactive protein (hs-CRP), glucose (Glu), triglyceride (TG), cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), superoxide dismutase (SOD), serum creatinine (SCr), serum uric acid (SUA) were measured in 6060healthy subjects (3672 male and 2388 female, mean age:45.9 years) who received routine physical examination at Sun Yat-sen Memorial Hospital, Guangzhou, China. Results In total of 6060 healthy people, serum levels of hs-CRP were significantly increased with ageing (P < 0.05), particularly in those with age over 45-year-old (1.31[0.69–2.75] vs 1.05[0.53–2.16]mg/L, P < 0.001). Interestingly, levels of serum hs-CRP were significantly higher in male than female population (1.24[0.65–2.57] vs 1.07[0.53–2.29]mg/L, P < 0.001). Correlation analysis also revealed that serum levels of hs-CRP positively correlated with age and SUA, but inversely correlated with serum levels of HDL-c and SOD (all P < 0.05). Conclusions Baseline levels of serum hs-CRP are increased with ageing and are significantly higher in male than female healthy population. In addition, elevated serum levels of hs-CRP are also associated with increased SUA but decreased HDL-c and SOD. Thus, serum levels of hs-CRP may be an indicator associated with ageing in healthy Chinese population.http://link.springer.com/article/10.1186/s12979-018-0126-7Hs-CRPAgeingInflammationRisk factor |
| spellingShingle | Ying Tang Peifen Liang Junzhe Chen Sha Fu Bo Liu Min Feng Baojuan Lin Ben Lee Anping Xu Hui Y. Lan The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population Immunity & Ageing Hs-CRP Ageing Inflammation Risk factor |
| title | The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population |
| title_full | The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population |
| title_fullStr | The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population |
| title_full_unstemmed | The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population |
| title_short | The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population |
| title_sort | baseline levels and risk factors for high sensitive c reactive protein in chinese healthy population |
| topic | Hs-CRP Ageing Inflammation Risk factor |
| url | http://link.springer.com/article/10.1186/s12979-018-0126-7 |
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