Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
Anti-TNF therapy has improved the treatment of inflammatory disease but can predispose to infection and malignancy. Here the authors show an anti-TNF biologic peptide that functionally and selectively targets the TNF-p38 pathway in multiple models of inflammation.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03640-y |
| _version_ | 1818855789302906880 |
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| author | Violet R. Mukaro Alex Quach Michelle E. Gahan Bernadette Boog Zhi H. Huang Xiuhui Gao Carol Haddad Suresh Mahalingam Charles S. Hii Antonio Ferrante |
| author_facet | Violet R. Mukaro Alex Quach Michelle E. Gahan Bernadette Boog Zhi H. Huang Xiuhui Gao Carol Haddad Suresh Mahalingam Charles S. Hii Antonio Ferrante |
| author_sort | Violet R. Mukaro |
| collection | DOAJ |
| description | Anti-TNF therapy has improved the treatment of inflammatory disease but can predispose to infection and malignancy. Here the authors show an anti-TNF biologic peptide that functionally and selectively targets the TNF-p38 pathway in multiple models of inflammation. |
| first_indexed | 2024-12-19T08:14:11Z |
| format | Article |
| id | doaj.art-6d8d32e467ee4dd0a9417a3616257e88 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:14:11Z |
| publishDate | 2018-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6d8d32e467ee4dd0a9417a3616257e882022-12-21T20:29:32ZengNature PortfolioNature Communications2041-17232018-04-019111310.1038/s41467-018-03640-ySmall tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammationViolet R. Mukaro0Alex Quach1Michelle E. Gahan2Bernadette Boog3Zhi H. Huang4Xiuhui Gao5Carol Haddad6Suresh Mahalingam7Charles S. Hii8Antonio Ferrante9Department of Immunopathology, SA Pathology, Women’s and Children’s HospitalDepartment of Immunopathology, SA Pathology, Women’s and Children’s HospitalFaculty of Science and Technology, University of CanberraDepartment of Immunopathology, SA Pathology, Women’s and Children’s HospitalDepartment of Immunopathology, SA Pathology, Women’s and Children’s HospitalDepartment of Immunopathology, SA Pathology, Women’s and Children’s HospitalDepartment of Immunopathology, SA Pathology, Women’s and Children’s HospitalEmerging Viruses and Inflammation Research Group, Institute of Glycomics, Griffith UniversityDepartment of Immunopathology, SA Pathology, Women’s and Children’s HospitalDepartment of Immunopathology, SA Pathology, Women’s and Children’s HospitalAnti-TNF therapy has improved the treatment of inflammatory disease but can predispose to infection and malignancy. Here the authors show an anti-TNF biologic peptide that functionally and selectively targets the TNF-p38 pathway in multiple models of inflammation.https://doi.org/10.1038/s41467-018-03640-y |
| spellingShingle | Violet R. Mukaro Alex Quach Michelle E. Gahan Bernadette Boog Zhi H. Huang Xiuhui Gao Carol Haddad Suresh Mahalingam Charles S. Hii Antonio Ferrante Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation Nature Communications |
| title | Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation |
| title_full | Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation |
| title_fullStr | Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation |
| title_full_unstemmed | Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation |
| title_short | Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation |
| title_sort | small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor p38 signalling axis and inflammation |
| url | https://doi.org/10.1038/s41467-018-03640-y |
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