Potential of Stimuli-Responsive In Situ Gel System for Sustained Ocular Drug Delivery: Recent Progress and Contemporary Research
Eyesight is one of the most well-deserved blessings, amid all the five senses in the human body. It captures the raw signals from the outside world to create detailed visual images, granting the ability to witness and gain knowledge about the world. Eyes are exposed directly to the external environm...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/8/1340 |
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| author | Manisha Pandey Hira Choudhury Azila binti Abd Aziz Subrat Kumar Bhattamisra Bapi Gorain Jocelyn Sziou Ting Su Choo Leey Tan Woon Yee Chin Khar Yee Yip |
| author_facet | Manisha Pandey Hira Choudhury Azila binti Abd Aziz Subrat Kumar Bhattamisra Bapi Gorain Jocelyn Sziou Ting Su Choo Leey Tan Woon Yee Chin Khar Yee Yip |
| author_sort | Manisha Pandey |
| collection | DOAJ |
| description | Eyesight is one of the most well-deserved blessings, amid all the five senses in the human body. It captures the raw signals from the outside world to create detailed visual images, granting the ability to witness and gain knowledge about the world. Eyes are exposed directly to the external environment; they are susceptible to the vicissitudes of diseases. The World Health Organization has predicted that the number of individuals affected by eye diseases will rise enormously in the next decades. However, the physical barriers of the eyes and the problems associated with conventional ocular formulations are significant challenges in ophthalmic drug development. This has generated the demand for a sustained ocular drug delivery system, which serves to deliver effective drug concentration at a reduced frequency for consistent therapeutic effect and better patient treatment adherence. Recent advancement in pharmaceutical dosage design has demonstrated that a stimuli-responsive in situ gel system exhibits the favorable characteristics for providing sustained ocular drug delivery and enhanced ocular bioavailability. Stimuli-responsive in situ gels undergo a phase transition (solution–gelation) in response to the ocular environmental temperature, pH, and ions. These stimuli transform the formulation into a gel at the cul de sac to overcome the shortcomings of conventional eye drops, such as rapid nasolacrimal drainage and short contact time with the ocular surface This review highlights the recent successful research outcomes of stimuli-responsive in situ gelling systems in treating in vivo models with glaucoma and various ocular infections. Additionally, it also presents the mechanism, recent development, and safety considerations of stimuli-sensitive in situ gel as the potential sustained ocular delivery system for treating common eye disorders. |
| first_indexed | 2024-03-10T12:10:36Z |
| format | Article |
| id | doaj.art-6d8d5e5b76664e049e038ac181921be3 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T12:10:36Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-6d8d5e5b76664e049e038ac181921be32023-11-21T16:16:01ZengMDPI AGPolymers2073-43602021-04-01138134010.3390/polym13081340Potential of Stimuli-Responsive In Situ Gel System for Sustained Ocular Drug Delivery: Recent Progress and Contemporary ResearchManisha Pandey0Hira Choudhury1Azila binti Abd Aziz2Subrat Kumar Bhattamisra3Bapi Gorain4Jocelyn Sziou Ting Su5Choo Leey Tan6Woon Yee Chin7Khar Yee Yip8Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaDepartment of Pharmaceutical Technology, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaDepartment of Chemical and Environmental Engineering, Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, Kuala Lumpur 54100, MalaysiaDepartment of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaSchool of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya 47500, Selangor, MalaysiaUndergraduate, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaUndergraduate, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaUndergraduate, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaUndergraduate, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaEyesight is one of the most well-deserved blessings, amid all the five senses in the human body. It captures the raw signals from the outside world to create detailed visual images, granting the ability to witness and gain knowledge about the world. Eyes are exposed directly to the external environment; they are susceptible to the vicissitudes of diseases. The World Health Organization has predicted that the number of individuals affected by eye diseases will rise enormously in the next decades. However, the physical barriers of the eyes and the problems associated with conventional ocular formulations are significant challenges in ophthalmic drug development. This has generated the demand for a sustained ocular drug delivery system, which serves to deliver effective drug concentration at a reduced frequency for consistent therapeutic effect and better patient treatment adherence. Recent advancement in pharmaceutical dosage design has demonstrated that a stimuli-responsive in situ gel system exhibits the favorable characteristics for providing sustained ocular drug delivery and enhanced ocular bioavailability. Stimuli-responsive in situ gels undergo a phase transition (solution–gelation) in response to the ocular environmental temperature, pH, and ions. These stimuli transform the formulation into a gel at the cul de sac to overcome the shortcomings of conventional eye drops, such as rapid nasolacrimal drainage and short contact time with the ocular surface This review highlights the recent successful research outcomes of stimuli-responsive in situ gelling systems in treating in vivo models with glaucoma and various ocular infections. Additionally, it also presents the mechanism, recent development, and safety considerations of stimuli-sensitive in situ gel as the potential sustained ocular delivery system for treating common eye disorders.https://www.mdpi.com/2073-4360/13/8/1340ocular drug deliverymucoadhesivein situ ophthalmic gelthermo-responsivepH-responsiveion-responsive |
| spellingShingle | Manisha Pandey Hira Choudhury Azila binti Abd Aziz Subrat Kumar Bhattamisra Bapi Gorain Jocelyn Sziou Ting Su Choo Leey Tan Woon Yee Chin Khar Yee Yip Potential of Stimuli-Responsive In Situ Gel System for Sustained Ocular Drug Delivery: Recent Progress and Contemporary Research Polymers ocular drug delivery mucoadhesive in situ ophthalmic gel thermo-responsive pH-responsive ion-responsive |
| title | Potential of Stimuli-Responsive In Situ Gel System for Sustained Ocular Drug Delivery: Recent Progress and Contemporary Research |
| title_full | Potential of Stimuli-Responsive In Situ Gel System for Sustained Ocular Drug Delivery: Recent Progress and Contemporary Research |
| title_fullStr | Potential of Stimuli-Responsive In Situ Gel System for Sustained Ocular Drug Delivery: Recent Progress and Contemporary Research |
| title_full_unstemmed | Potential of Stimuli-Responsive In Situ Gel System for Sustained Ocular Drug Delivery: Recent Progress and Contemporary Research |
| title_short | Potential of Stimuli-Responsive In Situ Gel System for Sustained Ocular Drug Delivery: Recent Progress and Contemporary Research |
| title_sort | potential of stimuli responsive in situ gel system for sustained ocular drug delivery recent progress and contemporary research |
| topic | ocular drug delivery mucoadhesive in situ ophthalmic gel thermo-responsive pH-responsive ion-responsive |
| url | https://www.mdpi.com/2073-4360/13/8/1340 |
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