Resting state functional connectivity differentiation of neuropathic and nociceptive pain in individuals with chronic spinal cord injury
Many individuals with spinal cord injury live with debilitating chronic pain that may be neuropathic, nociceptive, or a combination of both in nature. Identification of brain regions demonstrating altered connectivity associated with the type and severity of pain experience may elucidate underlying...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158223001031 |
| _version_ | 1797803932259450880 |
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| author | Jesse L. Kowalski Leslie R. Morse Karen Troy Nguyen Nguyen Ricardo A. Battaglino Scott P. Falci Clas Linnman |
| author_facet | Jesse L. Kowalski Leslie R. Morse Karen Troy Nguyen Nguyen Ricardo A. Battaglino Scott P. Falci Clas Linnman |
| author_sort | Jesse L. Kowalski |
| collection | DOAJ |
| description | Many individuals with spinal cord injury live with debilitating chronic pain that may be neuropathic, nociceptive, or a combination of both in nature. Identification of brain regions demonstrating altered connectivity associated with the type and severity of pain experience may elucidate underlying mechanisms, as well as treatment targets. Resting state and sensorimotor task-based magnetic resonance imaging data were collected in 37 individuals with chronic spinal cord injury. Seed-based correlations were utilized to identify resting state functional connectivity of regions with established roles in pain processing: the primary motor and somatosensory cortices, cingulate, insula, hippocampus, parahippocampal gyri, thalamus, amygdala, caudate, putamen, and periaqueductal gray matter. Resting state functional connectivity alterations and task-based activation associated with individuals’ pain type and intensity ratings on the International Spinal Cord Injury Basic Pain Dataset (0–10 scale) were evaluated. We found that intralimbic and limbostriatal resting state connectivity alterations are uniquely associated with neuropathic pain severity, whereas thalamocortical and thalamolimbic connectivity alterations are associated specifically with nociceptive pain severity. The joint effect and contrast of both pain types were associated with altered limbocortical connectivity. No significant differences in task-based activation were identified. These findings suggest that the experience of pain in individuals with spinal cord injury may be associated with unique alterations in resting state functional connectivity dependent upon pain type. |
| first_indexed | 2024-03-13T05:28:29Z |
| format | Article |
| id | doaj.art-6d8daeb7947a4fbf8c33f410672a0ef1 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-03-13T05:28:29Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-6d8daeb7947a4fbf8c33f410672a0ef12023-06-15T04:55:55ZengElsevierNeuroImage: Clinical2213-15822023-01-0138103414Resting state functional connectivity differentiation of neuropathic and nociceptive pain in individuals with chronic spinal cord injuryJesse L. Kowalski0Leslie R. Morse1Karen Troy2Nguyen Nguyen3Ricardo A. Battaglino4Scott P. Falci5Clas Linnman6Spaulding Neuroimaging Laboratory, Spaulding Rehabilitation Hospital, Harvard Medical School, 79/96 13th St, Charlestown, Boston, MA, United States; Department of Rehabilitation Medicine, University of Minnesota, MMC 297, 420 Delaware St. SE, Minneapolis, MN 55455, United StatesDepartment of Rehabilitation Medicine, University of Minnesota, MMC 297, 420 Delaware St. SE, Minneapolis, MN 55455, United States; Corresponding author at: Department of Rehabilitation Medicine, MMC 297, 420 Delaware St. SE, Minneapolis, MN 55455, United States.Department of Biomedical Engineering, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, United StatesDepartment of Rehabilitation Medicine, University of Minnesota, MMC 297, 420 Delaware St. SE, Minneapolis, MN 55455, United StatesDepartment of Rehabilitation Medicine, University of Minnesota, MMC 297, 420 Delaware St. SE, Minneapolis, MN 55455, United StatesDepartment of Rehabilitation Medicine, University of Minnesota, MMC 297, 420 Delaware St. SE, Minneapolis, MN 55455, United States; Department of Neurosurgery, Swedish Medical Center, 501 E Hampden Ave, Englewood, CO 80113, United StatesSpaulding Neuroimaging Laboratory, Spaulding Rehabilitation Hospital, Harvard Medical School, 79/96 13th St, Charlestown, Boston, MA, United States; Department of Rehabilitation Medicine, University of Minnesota, MMC 297, 420 Delaware St. SE, Minneapolis, MN 55455, United StatesMany individuals with spinal cord injury live with debilitating chronic pain that may be neuropathic, nociceptive, or a combination of both in nature. Identification of brain regions demonstrating altered connectivity associated with the type and severity of pain experience may elucidate underlying mechanisms, as well as treatment targets. Resting state and sensorimotor task-based magnetic resonance imaging data were collected in 37 individuals with chronic spinal cord injury. Seed-based correlations were utilized to identify resting state functional connectivity of regions with established roles in pain processing: the primary motor and somatosensory cortices, cingulate, insula, hippocampus, parahippocampal gyri, thalamus, amygdala, caudate, putamen, and periaqueductal gray matter. Resting state functional connectivity alterations and task-based activation associated with individuals’ pain type and intensity ratings on the International Spinal Cord Injury Basic Pain Dataset (0–10 scale) were evaluated. We found that intralimbic and limbostriatal resting state connectivity alterations are uniquely associated with neuropathic pain severity, whereas thalamocortical and thalamolimbic connectivity alterations are associated specifically with nociceptive pain severity. The joint effect and contrast of both pain types were associated with altered limbocortical connectivity. No significant differences in task-based activation were identified. These findings suggest that the experience of pain in individuals with spinal cord injury may be associated with unique alterations in resting state functional connectivity dependent upon pain type.http://www.sciencedirect.com/science/article/pii/S2213158223001031Neuropathic painNociceptive painResting state fMRIFunctional connectivitySpinal cord injury |
| spellingShingle | Jesse L. Kowalski Leslie R. Morse Karen Troy Nguyen Nguyen Ricardo A. Battaglino Scott P. Falci Clas Linnman Resting state functional connectivity differentiation of neuropathic and nociceptive pain in individuals with chronic spinal cord injury NeuroImage: Clinical Neuropathic pain Nociceptive pain Resting state fMRI Functional connectivity Spinal cord injury |
| title | Resting state functional connectivity differentiation of neuropathic and nociceptive pain in individuals with chronic spinal cord injury |
| title_full | Resting state functional connectivity differentiation of neuropathic and nociceptive pain in individuals with chronic spinal cord injury |
| title_fullStr | Resting state functional connectivity differentiation of neuropathic and nociceptive pain in individuals with chronic spinal cord injury |
| title_full_unstemmed | Resting state functional connectivity differentiation of neuropathic and nociceptive pain in individuals with chronic spinal cord injury |
| title_short | Resting state functional connectivity differentiation of neuropathic and nociceptive pain in individuals with chronic spinal cord injury |
| title_sort | resting state functional connectivity differentiation of neuropathic and nociceptive pain in individuals with chronic spinal cord injury |
| topic | Neuropathic pain Nociceptive pain Resting state fMRI Functional connectivity Spinal cord injury |
| url | http://www.sciencedirect.com/science/article/pii/S2213158223001031 |
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