Localized periodontitis severity associated with carotid intima-media thickness in young adults: CHIEF atherosclerosis study
Abstract This study aimed to investigate the association of periodontitis with subclinical atherosclerosis in young adults. In total, 486 non-diabetic military personnel were included in Taiwan. Carotid intima-media thickness (cIMT) was assessed utilizing sonography for subclinical atherosclerosis....
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Nature Portfolio
2023-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-37840-4 |
| _version_ | 1797789849298665472 |
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| author | Kun-Zhe Tsai Wei-Chun Huang Yun-Chen Chang Younghoon Kwon Xuemei Sui Carl J. Lavie Gen-Min Lin |
| author_facet | Kun-Zhe Tsai Wei-Chun Huang Yun-Chen Chang Younghoon Kwon Xuemei Sui Carl J. Lavie Gen-Min Lin |
| author_sort | Kun-Zhe Tsai |
| collection | DOAJ |
| description | Abstract This study aimed to investigate the association of periodontitis with subclinical atherosclerosis in young adults. In total, 486 non-diabetic military personnel were included in Taiwan. Carotid intima-media thickness (cIMT) was assessed utilizing sonography for subclinical atherosclerosis. Periodontitis severity was defined based on the 2017 US/European consensus. Mean cIMT was compared by analysis of covariance (ANCOVA), and multiple logistic regression model was used to determine the association of periodontitis severity and the highest quintile of cIMT (≥ 0.8 mm) with adjustments for age, sex, metabolic risk factors and leukocyte counts. The mean cIMT increased in those with greater stages (periodontal health (N = 349): 0.65 mm, Stage I (N = 41): 0.72 mm, Stage II (N = 57): 0.74 mm and Stage III: 0.76 mm, respectively, p < 0.01). In multiple logistic regression, a dose–response association from Stage I to Stage III periodontitis for cIMT ≥ 0.8 mm was also found [ORs and 95% CIs 1.41 (0.60–3.29), 1.62 (0.79–3.31) and 3.20 (1.42–7.18)]. Leucocyte counts ≥ 7.6 × 103/µL (the highest quintile) was associated with cIMT ≥ 0.8 mm [OR 1.86 (1.11–3.12)], while no association existed for other metabolic risk factors. In conclusion, severe periodontitis and leukocyte counts are independent risk factors of increased cIMT, emphasizing the critical role of inflammation in subclinical atherosclerosis. |
| first_indexed | 2024-03-13T01:56:23Z |
| format | Article |
| id | doaj.art-6d8f9ce7cc8440989ccf2e11d114f0c3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T01:56:23Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6d8f9ce7cc8440989ccf2e11d114f0c32023-07-02T11:13:01ZengNature PortfolioScientific Reports2045-23222023-06-011311910.1038/s41598-023-37840-4Localized periodontitis severity associated with carotid intima-media thickness in young adults: CHIEF atherosclerosis studyKun-Zhe Tsai0Wei-Chun Huang1Yun-Chen Chang2Younghoon Kwon3Xuemei Sui4Carl J. Lavie5Gen-Min Lin6Department of Internal Medicine, Hualien Armed Forces General HospitalDepartment of Critical Care Medicine, Kaohsiung Veterans General HospitalSchool of Nursing and Graduate Institute of Nursing, China Medical UniversityDepartment of Medicine, University of WashingtonDepartment of Exercise Science, Arnold School of Public Health, University of South CarolinaJohn Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of MedicineDepartment of Internal Medicine, Hualien Armed Forces General HospitalAbstract This study aimed to investigate the association of periodontitis with subclinical atherosclerosis in young adults. In total, 486 non-diabetic military personnel were included in Taiwan. Carotid intima-media thickness (cIMT) was assessed utilizing sonography for subclinical atherosclerosis. Periodontitis severity was defined based on the 2017 US/European consensus. Mean cIMT was compared by analysis of covariance (ANCOVA), and multiple logistic regression model was used to determine the association of periodontitis severity and the highest quintile of cIMT (≥ 0.8 mm) with adjustments for age, sex, metabolic risk factors and leukocyte counts. The mean cIMT increased in those with greater stages (periodontal health (N = 349): 0.65 mm, Stage I (N = 41): 0.72 mm, Stage II (N = 57): 0.74 mm and Stage III: 0.76 mm, respectively, p < 0.01). In multiple logistic regression, a dose–response association from Stage I to Stage III periodontitis for cIMT ≥ 0.8 mm was also found [ORs and 95% CIs 1.41 (0.60–3.29), 1.62 (0.79–3.31) and 3.20 (1.42–7.18)]. Leucocyte counts ≥ 7.6 × 103/µL (the highest quintile) was associated with cIMT ≥ 0.8 mm [OR 1.86 (1.11–3.12)], while no association existed for other metabolic risk factors. In conclusion, severe periodontitis and leukocyte counts are independent risk factors of increased cIMT, emphasizing the critical role of inflammation in subclinical atherosclerosis.https://doi.org/10.1038/s41598-023-37840-4 |
| spellingShingle | Kun-Zhe Tsai Wei-Chun Huang Yun-Chen Chang Younghoon Kwon Xuemei Sui Carl J. Lavie Gen-Min Lin Localized periodontitis severity associated with carotid intima-media thickness in young adults: CHIEF atherosclerosis study Scientific Reports |
| title | Localized periodontitis severity associated with carotid intima-media thickness in young adults: CHIEF atherosclerosis study |
| title_full | Localized periodontitis severity associated with carotid intima-media thickness in young adults: CHIEF atherosclerosis study |
| title_fullStr | Localized periodontitis severity associated with carotid intima-media thickness in young adults: CHIEF atherosclerosis study |
| title_full_unstemmed | Localized periodontitis severity associated with carotid intima-media thickness in young adults: CHIEF atherosclerosis study |
| title_short | Localized periodontitis severity associated with carotid intima-media thickness in young adults: CHIEF atherosclerosis study |
| title_sort | localized periodontitis severity associated with carotid intima media thickness in young adults chief atherosclerosis study |
| url | https://doi.org/10.1038/s41598-023-37840-4 |
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