Broadening the biocompatibility of gold nanorods from rat to Macaca fascicularis: advancing clinical potential
Abstract Background The biomedical field has used gold nanorods (GNRs) for decades; however, clinical trials and translation is limited except gold nanoshells. The preparation of gold nanoshells is more complex than that of polyethylene glycol-modified GNRs (PEG-GNRs), and it is difficult to ensure...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-00941-1 |
| _version_ | 1818012031136038912 |
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| author | Jinfeng Liao Taorang Tian Sirong Shi Xueping Xie Shuanglin Peng Ying Zhu Jingang Xiao Yunfeng Lin |
| author_facet | Jinfeng Liao Taorang Tian Sirong Shi Xueping Xie Shuanglin Peng Ying Zhu Jingang Xiao Yunfeng Lin |
| author_sort | Jinfeng Liao |
| collection | DOAJ |
| description | Abstract Background The biomedical field has used gold nanorods (GNRs) for decades; however, clinical trials and translation is limited except gold nanoshells. The preparation of gold nanoshells is more complex than that of polyethylene glycol-modified GNRs (PEG-GNRs), and it is difficult to ensure uniform thickness. It is important to encourage and broaden the use of the star member (PEG-GNRs) of gold nanoparticles family for clinical translation. Existing studies on PEG-GNRs are limited with no relevant systematic progression in non-human primates. Herein, we assessed the systematic biocompatibility of PEG-GNRs in rats and clinically relevant Macaca fascicularis. Results In this small animal study, we administrated multiple doses of PEG-GNRs to rats and observed good biocompatibility. In the non-human primate study, PEG-GNRs had a longer blood half-life and produced a negligible immune response. Histological analysis revealed no significant abnormality. Conclusions PEG-GNRs were well-tolerated with good biocompatibility in both small animals and large non-human primates. The information gained from the comprehensive systemic toxicity assessment of PEG-GNRs in M. fascicularis will be helpful for translation to clinical trials. Graphical abstract |
| first_indexed | 2024-04-14T06:15:52Z |
| format | Article |
| id | doaj.art-6d8fc195c2844da89a9c6022725791cf |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-14T06:15:52Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-6d8fc195c2844da89a9c6022725791cf2022-12-22T02:08:12ZengBMCJournal of Nanobiotechnology1477-31552021-06-0119111110.1186/s12951-021-00941-1Broadening the biocompatibility of gold nanorods from rat to Macaca fascicularis: advancing clinical potentialJinfeng Liao0Taorang Tian1Sirong Shi2Xueping Xie3Shuanglin Peng4Ying Zhu5Jingang Xiao6Yunfeng Lin7State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityDepartment of Oral and Maxillofacial Surgery, The Affiliated Stomatology Hospital of Southwest Medical UniversityDivision of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of SciencesDepartment of Oral and Maxillofacial Surgery, The Affiliated Stomatology Hospital of Southwest Medical UniversityState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityAbstract Background The biomedical field has used gold nanorods (GNRs) for decades; however, clinical trials and translation is limited except gold nanoshells. The preparation of gold nanoshells is more complex than that of polyethylene glycol-modified GNRs (PEG-GNRs), and it is difficult to ensure uniform thickness. It is important to encourage and broaden the use of the star member (PEG-GNRs) of gold nanoparticles family for clinical translation. Existing studies on PEG-GNRs are limited with no relevant systematic progression in non-human primates. Herein, we assessed the systematic biocompatibility of PEG-GNRs in rats and clinically relevant Macaca fascicularis. Results In this small animal study, we administrated multiple doses of PEG-GNRs to rats and observed good biocompatibility. In the non-human primate study, PEG-GNRs had a longer blood half-life and produced a negligible immune response. Histological analysis revealed no significant abnormality. Conclusions PEG-GNRs were well-tolerated with good biocompatibility in both small animals and large non-human primates. The information gained from the comprehensive systemic toxicity assessment of PEG-GNRs in M. fascicularis will be helpful for translation to clinical trials. Graphical abstracthttps://doi.org/10.1186/s12951-021-00941-1Gold nanorodsSystemic biocompatibilityMacaca fascicularisBlood clearanceBiodistributionMajor organ analysis |
| spellingShingle | Jinfeng Liao Taorang Tian Sirong Shi Xueping Xie Shuanglin Peng Ying Zhu Jingang Xiao Yunfeng Lin Broadening the biocompatibility of gold nanorods from rat to Macaca fascicularis: advancing clinical potential Journal of Nanobiotechnology Gold nanorods Systemic biocompatibility Macaca fascicularis Blood clearance Biodistribution Major organ analysis |
| title | Broadening the biocompatibility of gold nanorods from rat to Macaca fascicularis: advancing clinical potential |
| title_full | Broadening the biocompatibility of gold nanorods from rat to Macaca fascicularis: advancing clinical potential |
| title_fullStr | Broadening the biocompatibility of gold nanorods from rat to Macaca fascicularis: advancing clinical potential |
| title_full_unstemmed | Broadening the biocompatibility of gold nanorods from rat to Macaca fascicularis: advancing clinical potential |
| title_short | Broadening the biocompatibility of gold nanorods from rat to Macaca fascicularis: advancing clinical potential |
| title_sort | broadening the biocompatibility of gold nanorods from rat to macaca fascicularis advancing clinical potential |
| topic | Gold nanorods Systemic biocompatibility Macaca fascicularis Blood clearance Biodistribution Major organ analysis |
| url | https://doi.org/10.1186/s12951-021-00941-1 |
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