EGFR-Binding Peptides: From Computational Design towards Tumor-Targeting of Adeno-Associated Virus Capsids

EGFR-Binding Peptides: From Computational Design towards Tumor-Targeting of Adeno-Associated Virus Capsids

The epidermal growth factor receptor (EGFR) plays a central role in the progression of many solid tumors. We used this validated target to analyze the de novo design of EGFR-binding peptides and their application for the delivery of complex payloads via rational design of a viral vector. Peptides we...

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Bibliographic Details
Main Authors: Rebecca C. Feiner, Isabell Kemker, Lea Krutzke, Ellen Allmendinger, Daniel J. Mandell, Norbert Sewald, Stefan Kochanek, Kristian M. Müller
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
cyclic peptide
VDEPT
oncolytic virus
protein engineering
VP protein
synthetic biology
Online Access:https://www.mdpi.com/1422-0067/21/24/9535

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