Black and white teas as potential agents to combine with amphotericin B and protect red blood cells from amphotericin B-mediated toxicity
Abstract Amphotericin B is a fungicidal substance that is treatment of choice for most systemic fungal infections affecting immunocompromised patients. However, severe side effects have limited the utility of this drug. The aim of this study was to evaluate the antifungal effect of the combination o...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Instituto Internacional de Ecologia
2018-02-01
|
| Series: | Brazilian Journal of Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842018005003103&lng=en&tlng=en |
| _version_ | 1817986826722344960 |
|---|---|
| author | V. M. Oliveira N. M. Khalil E. Carraro |
| author_facet | V. M. Oliveira N. M. Khalil E. Carraro |
| author_sort | V. M. Oliveira |
| collection | DOAJ |
| description | Abstract Amphotericin B is a fungicidal substance that is treatment of choice for most systemic fungal infections affecting immunocompromised patients. However, severe side effects have limited the utility of this drug. The aim of this study was to evaluate the antifungal effect of the combination of amphotericin B with black tea or white tea and protective of citotoxic effect. The present study shows that white and black teas have additive effects with amphotericin B against some species Candida. In addition, the combination of white and black tea with amphotericin B may reduce the toxicity of amphotericin B to red blood cells. Our results suggest that white and black tea is a potential agent to combine with amphotericin for antifungal efficacy and to reduce the amphotericin dose to lessen side effects. |
| first_indexed | 2024-04-14T00:13:18Z |
| format | Article |
| id | doaj.art-6d91082068934bb59d29a75674423ae5 |
| institution | Directory Open Access Journal |
| issn | 1678-4375 |
| language | English |
| last_indexed | 2024-04-14T00:13:18Z |
| publishDate | 2018-02-01 |
| publisher | Instituto Internacional de Ecologia |
| record_format | Article |
| series | Brazilian Journal of Biology |
| spelling | doaj.art-6d91082068934bb59d29a75674423ae52022-12-22T02:23:13ZengInstituto Internacional de EcologiaBrazilian Journal of Biology1678-43752018-02-01010.1590/1519-6984.171693S1519-69842018005003103Black and white teas as potential agents to combine with amphotericin B and protect red blood cells from amphotericin B-mediated toxicityV. M. OliveiraN. M. KhalilE. CarraroAbstract Amphotericin B is a fungicidal substance that is treatment of choice for most systemic fungal infections affecting immunocompromised patients. However, severe side effects have limited the utility of this drug. The aim of this study was to evaluate the antifungal effect of the combination of amphotericin B with black tea or white tea and protective of citotoxic effect. The present study shows that white and black teas have additive effects with amphotericin B against some species Candida. In addition, the combination of white and black tea with amphotericin B may reduce the toxicity of amphotericin B to red blood cells. Our results suggest that white and black tea is a potential agent to combine with amphotericin for antifungal efficacy and to reduce the amphotericin dose to lessen side effects.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842018005003103&lng=en&tlng=enamphotericin Bantifungal.black teaCamellia sinensiswhite teatoxicity |
| spellingShingle | V. M. Oliveira N. M. Khalil E. Carraro Black and white teas as potential agents to combine with amphotericin B and protect red blood cells from amphotericin B-mediated toxicity Brazilian Journal of Biology amphotericin B antifungal. black tea Camellia sinensis white tea toxicity |
| title | Black and white teas as potential agents to combine with amphotericin B and protect red blood cells from amphotericin B-mediated toxicity |
| title_full | Black and white teas as potential agents to combine with amphotericin B and protect red blood cells from amphotericin B-mediated toxicity |
| title_fullStr | Black and white teas as potential agents to combine with amphotericin B and protect red blood cells from amphotericin B-mediated toxicity |
| title_full_unstemmed | Black and white teas as potential agents to combine with amphotericin B and protect red blood cells from amphotericin B-mediated toxicity |
| title_short | Black and white teas as potential agents to combine with amphotericin B and protect red blood cells from amphotericin B-mediated toxicity |
| title_sort | black and white teas as potential agents to combine with amphotericin b and protect red blood cells from amphotericin b mediated toxicity |
| topic | amphotericin B antifungal. black tea Camellia sinensis white tea toxicity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842018005003103&lng=en&tlng=en |
| work_keys_str_mv | AT vmoliveira blackandwhiteteasaspotentialagentstocombinewithamphotericinbandprotectredbloodcellsfromamphotericinbmediatedtoxicity AT nmkhalil blackandwhiteteasaspotentialagentstocombinewithamphotericinbandprotectredbloodcellsfromamphotericinbmediatedtoxicity AT ecarraro blackandwhiteteasaspotentialagentstocombinewithamphotericinbandprotectredbloodcellsfromamphotericinbmediatedtoxicity |