Relationship between the severity of pre-frailty and the degree of adaptation of Ninjin’yoeito (NYT) on pre-frailty
With the global trend towards longer life expectancies, there’s an increasing emphasis on not just living longer, but also maintaining health and wellbeing into older age. This study explores the efficacy of Ninjin’yoeito (NYT) in the early stages of frailty, a critical period for preventive interve...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Aging |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2024.1304217/full |
| _version_ | 1797213459117506560 |
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| author | Haruka Amitani Haruka Amitani Hajime Suzuki Hironori Kobayashi Masaru Murayama Nanami Sameshima Uto Eishi Kuroda Yoshiki Kobayashi Momoko Kawabe Marie Amitani Marie Amitani Akio Inui Yoshinori Marunaka Yoshinori Marunaka |
| author_facet | Haruka Amitani Haruka Amitani Hajime Suzuki Hironori Kobayashi Masaru Murayama Nanami Sameshima Uto Eishi Kuroda Yoshiki Kobayashi Momoko Kawabe Marie Amitani Marie Amitani Akio Inui Yoshinori Marunaka Yoshinori Marunaka |
| author_sort | Haruka Amitani |
| collection | DOAJ |
| description | With the global trend towards longer life expectancies, there’s an increasing emphasis on not just living longer, but also maintaining health and wellbeing into older age. This study explores the efficacy of Ninjin’yoeito (NYT) in the early stages of frailty, a critical period for preventive interventions. Taking account of the knowledge gap regarding the association between early frailty and NYT, we use data from workplace health checkups to examine the relationship between pre-frailty severity and NYT adaption. The objective of our research is to enhance the comprehension of early treatments using NYT to prevent the progression of frailty. A total of 314 employees of the Kyoto Industrial Health Association who received workplace health checkups between November 2021 and March 2023 and consented to this study were included in the analysis. Information on gender, age, body mass index (BMI), NYT-specific symptoms assessment, the Japanese version of the General Health Questionnaire-12 (GHQ-12), and the Kihon Checklist (KCL) were obtained. The correlation analysis revealed that there was a strong positive correlation between the number of applicable NYT indications and the GHQ-12 score (r = 0.5992, p < 0.0001). Similarly, a moderate positive correlation was observed between the number of applicable NYT indications and the KCL score (r = 0.5030, p < 0.0001). In the multivariate analysis, both GHQ-12 (β = 0.49, SE = 0.06, t = 7.66, 95% CI: 0.36 to 0.62, p = 0.000) and KCL (β = 0.54, SE = 0.12, t = 4.29, 95% CI: 0.29 to 0.79, p = 0.000) showed significant positive associations with the variance in the number of applicable NYT indications, indicating that higher scores on these measures were related to a greater number of indications. NYT has the potential to be utilized not only as a therapeutic intervention for frailty, but also as a preventive measure. |
| first_indexed | 2024-04-24T10:58:37Z |
| format | Article |
| id | doaj.art-6d9277625ebb47c89c8702806095e9fc |
| institution | Directory Open Access Journal |
| issn | 2673-6217 |
| language | English |
| last_indexed | 2024-04-24T10:58:37Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging |
| spelling | doaj.art-6d9277625ebb47c89c8702806095e9fc2024-04-12T04:24:23ZengFrontiers Media S.A.Frontiers in Aging2673-62172024-04-01510.3389/fragi.2024.13042171304217Relationship between the severity of pre-frailty and the degree of adaptation of Ninjin’yoeito (NYT) on pre-frailtyHaruka Amitani0Haruka Amitani1Hajime Suzuki2Hironori Kobayashi3Masaru Murayama4Nanami Sameshima Uto5Eishi Kuroda6Yoshiki Kobayashi7Momoko Kawabe8Marie Amitani9Marie Amitani10Akio Inui11Yoshinori Marunaka12Yoshinori Marunaka13Pharmacological Department of Herbal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanDivision of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanDivision of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanMedical Research Institute, Kyoto Industrial Health Association, Kyoto, JapanMedical Research Institute, Kyoto Industrial Health Association, Kyoto, JapanPharmacological Department of Herbal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanPharmacological Department of Herbal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanKampo Research Laboratories, Kracie Pharma, Ltd, Tokyo, JapanKampo Research Laboratories, Kracie Pharma, Ltd, Tokyo, JapanEducation Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanDivision of Community-Based Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanPharmacological Department of Herbal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanMedical Research Institute, Kyoto Industrial Health Association, Kyoto, JapanResearch Organization of Science and Technology, Ritsumeikan University, Kusatsu, JapanWith the global trend towards longer life expectancies, there’s an increasing emphasis on not just living longer, but also maintaining health and wellbeing into older age. This study explores the efficacy of Ninjin’yoeito (NYT) in the early stages of frailty, a critical period for preventive interventions. Taking account of the knowledge gap regarding the association between early frailty and NYT, we use data from workplace health checkups to examine the relationship between pre-frailty severity and NYT adaption. The objective of our research is to enhance the comprehension of early treatments using NYT to prevent the progression of frailty. A total of 314 employees of the Kyoto Industrial Health Association who received workplace health checkups between November 2021 and March 2023 and consented to this study were included in the analysis. Information on gender, age, body mass index (BMI), NYT-specific symptoms assessment, the Japanese version of the General Health Questionnaire-12 (GHQ-12), and the Kihon Checklist (KCL) were obtained. The correlation analysis revealed that there was a strong positive correlation between the number of applicable NYT indications and the GHQ-12 score (r = 0.5992, p < 0.0001). Similarly, a moderate positive correlation was observed between the number of applicable NYT indications and the KCL score (r = 0.5030, p < 0.0001). In the multivariate analysis, both GHQ-12 (β = 0.49, SE = 0.06, t = 7.66, 95% CI: 0.36 to 0.62, p = 0.000) and KCL (β = 0.54, SE = 0.12, t = 4.29, 95% CI: 0.29 to 0.79, p = 0.000) showed significant positive associations with the variance in the number of applicable NYT indications, indicating that higher scores on these measures were related to a greater number of indications. NYT has the potential to be utilized not only as a therapeutic intervention for frailty, but also as a preventive measure.https://www.frontiersin.org/articles/10.3389/fragi.2024.1304217/fullfrailtyNinjin’yoeito (NYT)Revised Japanese version of the cardiovascular health study (revised J-CHS)Kihon checklist (KCL)general health questionnaire 12 (GHQ12) |
| spellingShingle | Haruka Amitani Haruka Amitani Hajime Suzuki Hironori Kobayashi Masaru Murayama Nanami Sameshima Uto Eishi Kuroda Yoshiki Kobayashi Momoko Kawabe Marie Amitani Marie Amitani Akio Inui Yoshinori Marunaka Yoshinori Marunaka Relationship between the severity of pre-frailty and the degree of adaptation of Ninjin’yoeito (NYT) on pre-frailty Frontiers in Aging frailty Ninjin’yoeito (NYT) Revised Japanese version of the cardiovascular health study (revised J-CHS) Kihon checklist (KCL) general health questionnaire 12 (GHQ12) |
| title | Relationship between the severity of pre-frailty and the degree of adaptation of Ninjin’yoeito (NYT) on pre-frailty |
| title_full | Relationship between the severity of pre-frailty and the degree of adaptation of Ninjin’yoeito (NYT) on pre-frailty |
| title_fullStr | Relationship between the severity of pre-frailty and the degree of adaptation of Ninjin’yoeito (NYT) on pre-frailty |
| title_full_unstemmed | Relationship between the severity of pre-frailty and the degree of adaptation of Ninjin’yoeito (NYT) on pre-frailty |
| title_short | Relationship between the severity of pre-frailty and the degree of adaptation of Ninjin’yoeito (NYT) on pre-frailty |
| title_sort | relationship between the severity of pre frailty and the degree of adaptation of ninjin yoeito nyt on pre frailty |
| topic | frailty Ninjin’yoeito (NYT) Revised Japanese version of the cardiovascular health study (revised J-CHS) Kihon checklist (KCL) general health questionnaire 12 (GHQ12) |
| url | https://www.frontiersin.org/articles/10.3389/fragi.2024.1304217/full |
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