Uncovering the Molecular Basis for the Better Gefitinib Sensitivity of EGFR with Complex Mutations over Single Rare Mutation: Insights from Molecular Simulations

Uncovering the Molecular Basis for the Better Gefitinib Sensitivity of EGFR with Complex Mutations over Single Rare Mutation: Insights from Molecular Simulations

Epidermal growth factor receptor (EGFR) is an intensively focused target for anti-tumor compounds used in non-small cell lung cancer (NSCLC) therapy. Compared to the classical activating mutations, there are still many uncommon EGFR mutations associated with poorer responses to EGFR inhibitors. A de...

Full description

Bibliographic Details
Main Authors: Miaomiao Li, Mengrong Li, Yanjie Xie, Jingjing Guo
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
EGFR rare mutants
EGFR complex mutations
molecular dynamics simulation
steered molecular dynamics simulation
Gefitinib (IRE)
Online Access:https://www.mdpi.com/1420-3049/27/12/3844

Similar Items

Similar Items