Effects of Maternal Separation and Subsequent Stress on Behaviors and Brain Monoamines in Rats
Childhood adversity can induce maladaptive behaviors and increase risk for affective disorders, post-traumatic stress disorder, personality disorders, and vulnerability to stress in adulthood. Deprivation of maternal care interrupts brain development through the disturbance of various neurotransmitt...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/6/956 |
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| author | Polina V. Mavrenkova Nadezhda N. Khlebnikova Irina B. Alchinova Marina S. Demorzhi Batozhab B. Shoibonov Mikhail Yu. Karganov |
| author_facet | Polina V. Mavrenkova Nadezhda N. Khlebnikova Irina B. Alchinova Marina S. Demorzhi Batozhab B. Shoibonov Mikhail Yu. Karganov |
| author_sort | Polina V. Mavrenkova |
| collection | DOAJ |
| description | Childhood adversity can induce maladaptive behaviors and increase risk for affective disorders, post-traumatic stress disorder, personality disorders, and vulnerability to stress in adulthood. Deprivation of maternal care interrupts brain development through the disturbance of various neurotransmitters, however, the details remain unclear. The features of the symptoms of disorders are largely determined by early stress protocol, genetic characteristics (line), and the sex of the animals. The purpose of current study was (1) to assess behavioral changes in adult Wistar rats of both sexes after early life stress; (2) to determine the levels of monoamines in brain structures involved in the motor, emotional, and social reactions in rats aged 1 and 2 months; and (3) to determine the level of monoamines after physical or emotional stress in adult rats. The rat pups were separated from their dams and isolated from siblings in tight boxes at a temperature of 22–23 °C for 6 h during postnatal days 2–18. The data were processed predominantly using two-way analysis of variance and the Newman–Keys test as the post hoc analysis. The adult rats demonstrated an increase in motor activity and aggressiveness and a decrease in levels of anxiety and sociability. Behavioral disturbances were accompanied by region-, sex-, and age-dependent changes in the levels of monoamines and their metabolites. The dopaminergic and noradrenergic systems were found to be sensitive to psycho-emotional stress. |
| first_indexed | 2024-03-11T02:40:46Z |
| format | Article |
| id | doaj.art-6d93d244bc384c8da2853eddc3a6aa22 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T02:40:46Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-6d93d244bc384c8da2853eddc3a6aa222023-11-18T09:36:54ZengMDPI AGBrain Sciences2076-34252023-06-0113695610.3390/brainsci13060956Effects of Maternal Separation and Subsequent Stress on Behaviors and Brain Monoamines in RatsPolina V. Mavrenkova0Nadezhda N. Khlebnikova1Irina B. Alchinova2Marina S. Demorzhi3Batozhab B. Shoibonov4Mikhail Yu. Karganov5Institute of General Pathology and Pathophysiology, 8 Baltiyskaya St., 125315 Moscow, RussiaInstitute of General Pathology and Pathophysiology, 8 Baltiyskaya St., 125315 Moscow, RussiaInstitute of General Pathology and Pathophysiology, 8 Baltiyskaya St., 125315 Moscow, RussiaInstitute of General Pathology and Pathophysiology, 8 Baltiyskaya St., 125315 Moscow, RussiaP. K. Anokhin Institute of Normal Physiology, 8 Baltiyskaya St., 125315 Moscow, RussiaInstitute of General Pathology and Pathophysiology, 8 Baltiyskaya St., 125315 Moscow, RussiaChildhood adversity can induce maladaptive behaviors and increase risk for affective disorders, post-traumatic stress disorder, personality disorders, and vulnerability to stress in adulthood. Deprivation of maternal care interrupts brain development through the disturbance of various neurotransmitters, however, the details remain unclear. The features of the symptoms of disorders are largely determined by early stress protocol, genetic characteristics (line), and the sex of the animals. The purpose of current study was (1) to assess behavioral changes in adult Wistar rats of both sexes after early life stress; (2) to determine the levels of monoamines in brain structures involved in the motor, emotional, and social reactions in rats aged 1 and 2 months; and (3) to determine the level of monoamines after physical or emotional stress in adult rats. The rat pups were separated from their dams and isolated from siblings in tight boxes at a temperature of 22–23 °C for 6 h during postnatal days 2–18. The data were processed predominantly using two-way analysis of variance and the Newman–Keys test as the post hoc analysis. The adult rats demonstrated an increase in motor activity and aggressiveness and a decrease in levels of anxiety and sociability. Behavioral disturbances were accompanied by region-, sex-, and age-dependent changes in the levels of monoamines and their metabolites. The dopaminergic and noradrenergic systems were found to be sensitive to psycho-emotional stress.https://www.mdpi.com/2076-3425/13/6/956ratmaternal separationhyperactive phenotypemonoamines in brain structures |
| spellingShingle | Polina V. Mavrenkova Nadezhda N. Khlebnikova Irina B. Alchinova Marina S. Demorzhi Batozhab B. Shoibonov Mikhail Yu. Karganov Effects of Maternal Separation and Subsequent Stress on Behaviors and Brain Monoamines in Rats Brain Sciences rat maternal separation hyperactive phenotype monoamines in brain structures |
| title | Effects of Maternal Separation and Subsequent Stress on Behaviors and Brain Monoamines in Rats |
| title_full | Effects of Maternal Separation and Subsequent Stress on Behaviors and Brain Monoamines in Rats |
| title_fullStr | Effects of Maternal Separation and Subsequent Stress on Behaviors and Brain Monoamines in Rats |
| title_full_unstemmed | Effects of Maternal Separation and Subsequent Stress on Behaviors and Brain Monoamines in Rats |
| title_short | Effects of Maternal Separation and Subsequent Stress on Behaviors and Brain Monoamines in Rats |
| title_sort | effects of maternal separation and subsequent stress on behaviors and brain monoamines in rats |
| topic | rat maternal separation hyperactive phenotype monoamines in brain structures |
| url | https://www.mdpi.com/2076-3425/13/6/956 |
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