ISFET‐based sensors for (bio)chemical applications: A review
Abstract Ion‐sensitive field effect transistor (ISFET) sensor is a hot topic these years, playing the combined roles of signal recognizer and converter for (bio)chemical analytes. In this review article, the basic concept, origination, and history of the ISFET sensor are presented. In addition, the...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-08-01
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| Series: | Electrochemical Science Advances |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/elsa.202100207 |
| _version_ | 1797742382753513472 |
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| author | Shengli Cao Peng Sun Gang Xiao Qiang Tang Xinyue Sun Hongyu Zhao Shuang Zhao Huibin Lu Zhao Yue |
| author_facet | Shengli Cao Peng Sun Gang Xiao Qiang Tang Xinyue Sun Hongyu Zhao Shuang Zhao Huibin Lu Zhao Yue |
| author_sort | Shengli Cao |
| collection | DOAJ |
| description | Abstract Ion‐sensitive field effect transistor (ISFET) sensor is a hot topic these years, playing the combined roles of signal recognizer and converter for (bio)chemical analytes. In this review article, the basic concept, origination, and history of the ISFET sensor are presented. In addition, the common fabrication processes, the most‐used working principle (potentiometric, amperometric, and impedancemetric), and the techniques of gate functionality (physical, chemical, and biological) are discussed introducing the afterward signal transfer processes from ISFET to the terminals through different types of circuits. At last, the development and recent progress (until 2021) of ions and biomolecules (DNA molecules, antibodies, enzymatic substrates, and cell‐related secretions or metabolism) were introduced together with the outlook and facing obstacles (Debye screening, the wearability of ISFET, the multiplexed detections) before the commercialization of ISFET. This review article emphasizes the advantages of the developed ISFET sensors as miniaturization, low‐cost, all‐solid, highly sensitive, and easy operation for portable and multiplexed detections. |
| first_indexed | 2024-03-12T14:41:03Z |
| format | Article |
| id | doaj.art-6d94bfc084ff41cd8c0ad896c1e48a40 |
| institution | Directory Open Access Journal |
| issn | 2698-5977 |
| language | English |
| last_indexed | 2024-03-12T14:41:03Z |
| publishDate | 2023-08-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Electrochemical Science Advances |
| spelling | doaj.art-6d94bfc084ff41cd8c0ad896c1e48a402023-08-16T08:42:45ZengWiley-VCHElectrochemical Science Advances2698-59772023-08-0134n/an/a10.1002/elsa.202100207ISFET‐based sensors for (bio)chemical applications: A reviewShengli Cao0Peng Sun1Gang Xiao2Qiang Tang3Xinyue Sun4Hongyu Zhao5Shuang Zhao6Huibin Lu7Zhao Yue8Department of Microelectronics Nankai University Tianjin P. R. ChinaDepartment of Microelectronics Nankai University Tianjin P. R. ChinaDepartment of Microelectronics Nankai University Tianjin P. R. ChinaSchool of Information Science and Engineering Yanshan University Qinhuangdao P. R. ChinaDepartment of Microelectronics Nankai University Tianjin P. R. ChinaSchool of Information Science and Engineering Yanshan University Qinhuangdao P. R. ChinaSchool of Information Science and Engineering Yanshan University Qinhuangdao P. R. ChinaSchool of Information Science and Engineering Yanshan University Qinhuangdao P. R. ChinaDepartment of Microelectronics Nankai University Tianjin P. R. ChinaAbstract Ion‐sensitive field effect transistor (ISFET) sensor is a hot topic these years, playing the combined roles of signal recognizer and converter for (bio)chemical analytes. In this review article, the basic concept, origination, and history of the ISFET sensor are presented. In addition, the common fabrication processes, the most‐used working principle (potentiometric, amperometric, and impedancemetric), and the techniques of gate functionality (physical, chemical, and biological) are discussed introducing the afterward signal transfer processes from ISFET to the terminals through different types of circuits. At last, the development and recent progress (until 2021) of ions and biomolecules (DNA molecules, antibodies, enzymatic substrates, and cell‐related secretions or metabolism) were introduced together with the outlook and facing obstacles (Debye screening, the wearability of ISFET, the multiplexed detections) before the commercialization of ISFET. This review article emphasizes the advantages of the developed ISFET sensors as miniaturization, low‐cost, all‐solid, highly sensitive, and easy operation for portable and multiplexed detections.https://doi.org/10.1002/elsa.202100207BiosensorsISFETMultiplexed detectionPortable sensorSensing arrays |
| spellingShingle | Shengli Cao Peng Sun Gang Xiao Qiang Tang Xinyue Sun Hongyu Zhao Shuang Zhao Huibin Lu Zhao Yue ISFET‐based sensors for (bio)chemical applications: A review Electrochemical Science Advances Biosensors ISFET Multiplexed detection Portable sensor Sensing arrays |
| title | ISFET‐based sensors for (bio)chemical applications: A review |
| title_full | ISFET‐based sensors for (bio)chemical applications: A review |
| title_fullStr | ISFET‐based sensors for (bio)chemical applications: A review |
| title_full_unstemmed | ISFET‐based sensors for (bio)chemical applications: A review |
| title_short | ISFET‐based sensors for (bio)chemical applications: A review |
| title_sort | isfet based sensors for bio chemical applications a review |
| topic | Biosensors ISFET Multiplexed detection Portable sensor Sensing arrays |
| url | https://doi.org/10.1002/elsa.202100207 |
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