Role of Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance
Long non-coding RNAs (lncRNAs) are single-stranded RNA biomolecules with a length of >200 nt, and they are currently considered to be master regulators of many pathological processes. Recent publications have shown that lncRNAs play important roles in the pathogenesis and progression of insulin r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/14/7256 |
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| author | Vianet Argelia Tello-Flores Fredy Omar Beltrán-Anaya Marco Antonio Ramírez-Vargas Brenda Ely Esteban-Casales Napoleón Navarro-Tito Luz del Carmen Alarcón-Romero Carlos Aldair Luciano-Villa Mónica Ramírez Óscar del Moral-Hernández Eugenia Flores-Alfaro |
| author_facet | Vianet Argelia Tello-Flores Fredy Omar Beltrán-Anaya Marco Antonio Ramírez-Vargas Brenda Ely Esteban-Casales Napoleón Navarro-Tito Luz del Carmen Alarcón-Romero Carlos Aldair Luciano-Villa Mónica Ramírez Óscar del Moral-Hernández Eugenia Flores-Alfaro |
| author_sort | Vianet Argelia Tello-Flores |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) are single-stranded RNA biomolecules with a length of >200 nt, and they are currently considered to be master regulators of many pathological processes. Recent publications have shown that lncRNAs play important roles in the pathogenesis and progression of insulin resistance (IR) and glucose homeostasis by regulating inflammatory and lipogenic processes. lncRNAs regulate gene expression by binding to other non-coding RNAs, mRNAs, proteins, and DNA. In recent years, several mechanisms have been reported to explain the key roles of lncRNAs in the development of IR, including metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), imprinted maternal-ly expressed transcript (H19), maternally expressed gene 3 (MEG3), myocardial infarction-associated transcript (MIAT), and steroid receptor RNA activator (SRA), HOX transcript antisense RNA (HOTAIR), and downregulated Expression-Related Hexose/Glucose Transport Enhancer (DREH). LncRNAs participate in the regulation of lipid and carbohydrate metabolism, the inflammatory process, and oxidative stress through different pathways, such as cyclic adenosine monophosphate/protein kinase A (cAMP/PKA), phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), polypyrimidine tract-binding protein 1/element-binding transcription factor 1c (PTBP1/SREBP-1c), AKT/nitric oxide synthase (eNOS), AKT/forkhead box O1 (FoxO1), and tumor necrosis factor-alpha (TNF-α)/c-Jun-N-terminal kinases (JNK). On the other hand, the mechanisms linked to the molecular, cellular, and biochemical actions of lncRNAs vary according to the tissue, biological species, and the severity of IR. Therefore, it is essential to elucidate the role of lncRNAs in the insulin signaling pathway and glucose and lipid metabolism. This review analyzes the function and molecular mechanisms of lncRNAs involved in the development of IR. |
| first_indexed | 2024-03-10T09:38:14Z |
| format | Article |
| id | doaj.art-6d94ebbf60a547c4a7f44fc4ced689bd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:38:14Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6d94ebbf60a547c4a7f44fc4ced689bd2023-11-22T03:55:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012214725610.3390/ijms22147256Role of Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin ResistanceVianet Argelia Tello-Flores0Fredy Omar Beltrán-Anaya1Marco Antonio Ramírez-Vargas2Brenda Ely Esteban-Casales3Napoleón Navarro-Tito4Luz del Carmen Alarcón-Romero5Carlos Aldair Luciano-Villa6Mónica Ramírez7Óscar del Moral-Hernández8Eugenia Flores-Alfaro9Laboratorio de Epidemiología Clínica y Molecular, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39087, GRO, MexicoLaboratorio de Epidemiología Clínica y Molecular, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39087, GRO, MexicoLaboratorio de Epidemiología Clínica y Molecular, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39087, GRO, MexicoLaboratorio de Epidemiología Clínica y Molecular, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39087, GRO, MexicoLaboratorio de Biología Celular del Cáncer, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39087, GRO, MexicoLaboratorio de Citopatología e Histoquímica, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39087, GRO, MexicoLaboratorio de Epidemiología Clínica y Molecular, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39087, GRO, MexicoCONACyT, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39087, GRO, MexicoLaboratorio de Virología, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39087, GRO, MexicoLaboratorio de Epidemiología Clínica y Molecular, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39087, GRO, MexicoLong non-coding RNAs (lncRNAs) are single-stranded RNA biomolecules with a length of >200 nt, and they are currently considered to be master regulators of many pathological processes. Recent publications have shown that lncRNAs play important roles in the pathogenesis and progression of insulin resistance (IR) and glucose homeostasis by regulating inflammatory and lipogenic processes. lncRNAs regulate gene expression by binding to other non-coding RNAs, mRNAs, proteins, and DNA. In recent years, several mechanisms have been reported to explain the key roles of lncRNAs in the development of IR, including metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), imprinted maternal-ly expressed transcript (H19), maternally expressed gene 3 (MEG3), myocardial infarction-associated transcript (MIAT), and steroid receptor RNA activator (SRA), HOX transcript antisense RNA (HOTAIR), and downregulated Expression-Related Hexose/Glucose Transport Enhancer (DREH). LncRNAs participate in the regulation of lipid and carbohydrate metabolism, the inflammatory process, and oxidative stress through different pathways, such as cyclic adenosine monophosphate/protein kinase A (cAMP/PKA), phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), polypyrimidine tract-binding protein 1/element-binding transcription factor 1c (PTBP1/SREBP-1c), AKT/nitric oxide synthase (eNOS), AKT/forkhead box O1 (FoxO1), and tumor necrosis factor-alpha (TNF-α)/c-Jun-N-terminal kinases (JNK). On the other hand, the mechanisms linked to the molecular, cellular, and biochemical actions of lncRNAs vary according to the tissue, biological species, and the severity of IR. Therefore, it is essential to elucidate the role of lncRNAs in the insulin signaling pathway and glucose and lipid metabolism. This review analyzes the function and molecular mechanisms of lncRNAs involved in the development of IR.https://www.mdpi.com/1422-0067/22/14/7256long non-coding RNAsinsulin resistanceMALAT1H19MEG3MIAT |
| spellingShingle | Vianet Argelia Tello-Flores Fredy Omar Beltrán-Anaya Marco Antonio Ramírez-Vargas Brenda Ely Esteban-Casales Napoleón Navarro-Tito Luz del Carmen Alarcón-Romero Carlos Aldair Luciano-Villa Mónica Ramírez Óscar del Moral-Hernández Eugenia Flores-Alfaro Role of Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance International Journal of Molecular Sciences long non-coding RNAs insulin resistance MALAT1 H19 MEG3 MIAT |
| title | Role of Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance |
| title_full | Role of Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance |
| title_fullStr | Role of Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance |
| title_full_unstemmed | Role of Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance |
| title_short | Role of Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance |
| title_sort | role of long non coding rnas and the molecular mechanisms involved in insulin resistance |
| topic | long non-coding RNAs insulin resistance MALAT1 H19 MEG3 MIAT |
| url | https://www.mdpi.com/1422-0067/22/14/7256 |
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