JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with heterogeneous manifestations that can substantially affect patients' quality of life. AD has a complex pathogenesis, making treatment challenging for dermatologists. The Janus kinase (JAK)–signal transducer and...
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1068260/full |
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| author | I-Hsin Huang I-Hsin Huang I-Hsin Huang Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Po-Chien Wu Po-Chien Wu Po-Chien Wu Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen |
| author_facet | I-Hsin Huang I-Hsin Huang I-Hsin Huang Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Po-Chien Wu Po-Chien Wu Po-Chien Wu Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen |
| author_sort | I-Hsin Huang |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with heterogeneous manifestations that can substantially affect patients' quality of life. AD has a complex pathogenesis, making treatment challenging for dermatologists. The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway plays a central role in modulating multiple immune axes involved in the immunopathogenesis of AD. In particular, Th2 cytokines, including interleukin (IL)-4, IL-5, IL-13, IL-31, and thymic stromal lymphopoietin, which contribute to the symptoms of chronic inflammation and pruritus in AD, are mediated by JAK–STAT signal transduction. Furthermore, JAK–STAT is involved in the regulation of the epidermal barrier and the modulation of peripheral nerves related to the transduction of pruritus. Targeting the JAK–STAT pathway may attenuate these signals and show clinical efficacy through the suppression of various immune pathways associated with AD. Topical and oral JAK inhibitors with variable selectivity have emerged as promising therapeutic options for AD. Notably, topical ruxolitinib, oral upadacitinib, and oral abrocitinib were approved by the U.S. Food and Drug Administration for treating patients with AD. Accordingly, the present study reviewed the role of JAK–STAT pathways in the pathogenesis of AD and explored updated applications of JAK inhibitors in treating AD. |
| first_indexed | 2024-04-12T03:42:05Z |
| format | Article |
| id | doaj.art-6d9620a7a26e4f1fac07b0904fd063ee |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T03:42:05Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6d9620a7a26e4f1fac07b0904fd063ee2022-12-22T03:49:15ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-12-011310.3389/fimmu.2022.10682601068260JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated reviewI-Hsin Huang0I-Hsin Huang1I-Hsin Huang2Wen-Hung Chung3Wen-Hung Chung4Wen-Hung Chung5Wen-Hung Chung6Wen-Hung Chung7Wen-Hung Chung8Wen-Hung Chung9Wen-Hung Chung10Wen-Hung Chung11Wen-Hung Chung12Po-Chien Wu13Po-Chien Wu14Po-Chien Wu15Chun-Bing Chen16Chun-Bing Chen17Chun-Bing Chen18Chun-Bing Chen19Chun-Bing Chen20Chun-Bing Chen21Chun-Bing Chen22Chun-Bing Chen23Chun-Bing Chen24Chun-Bing Chen25Chun-Bing Chen26Chun-Bing Chen27Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei, and Keelung, Taoyuan, TaiwanDepartment of Dermatology, Chang Gung Memorial Hospital, Linkou, Taipei and Keelung, TaiwanResearch Center of Big Data and Meta-analysis, Wan Fang Hospital, Taipei Medical University, Taipei, TaiwanDrug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei, and Keelung, Taoyuan, TaiwanDepartment of Dermatology, Chang Gung Memorial Hospital, Linkou, Taipei and Keelung, TaiwanCancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Linkou, TaiwanChang Gung Immunology Consortium, Chang Gung Memorial Hospital, Linkou, and Chang Gung University, Taoyuan, TaiwanDepartment of Dermatology, Xiamen Chang Gung Hospital, Xiamen, ChinaXiamen Chang Gung Allergology Consortium, Xiamen, Xiamen Chang Gung Hospital, Xiamen, ChinaCollege of Medicine, Chang Gung University, Taoyuan, TaiwanWhole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan0Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, Taiwan1Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, TaiwanDrug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei, and Keelung, Taoyuan, TaiwanDepartment of Dermatology, Chang Gung Memorial Hospital, Linkou, Taipei and Keelung, TaiwanResearch Center of Big Data and Meta-analysis, Wan Fang Hospital, Taipei Medical University, Taipei, TaiwanDrug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei, and Keelung, Taoyuan, TaiwanDepartment of Dermatology, Chang Gung Memorial Hospital, Linkou, Taipei and Keelung, TaiwanCancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Linkou, TaiwanChang Gung Immunology Consortium, Chang Gung Memorial Hospital, Linkou, and Chang Gung University, Taoyuan, TaiwanDepartment of Dermatology, Xiamen Chang Gung Hospital, Xiamen, ChinaXiamen Chang Gung Allergology Consortium, Xiamen, Xiamen Chang Gung Hospital, Xiamen, ChinaCollege of Medicine, Chang Gung University, Taoyuan, TaiwanWhole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan0Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, Taiwan1Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan2Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan3School of Medicine, National Tsing Hua University, Hsinchu, TaiwanAtopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with heterogeneous manifestations that can substantially affect patients' quality of life. AD has a complex pathogenesis, making treatment challenging for dermatologists. The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway plays a central role in modulating multiple immune axes involved in the immunopathogenesis of AD. In particular, Th2 cytokines, including interleukin (IL)-4, IL-5, IL-13, IL-31, and thymic stromal lymphopoietin, which contribute to the symptoms of chronic inflammation and pruritus in AD, are mediated by JAK–STAT signal transduction. Furthermore, JAK–STAT is involved in the regulation of the epidermal barrier and the modulation of peripheral nerves related to the transduction of pruritus. Targeting the JAK–STAT pathway may attenuate these signals and show clinical efficacy through the suppression of various immune pathways associated with AD. Topical and oral JAK inhibitors with variable selectivity have emerged as promising therapeutic options for AD. Notably, topical ruxolitinib, oral upadacitinib, and oral abrocitinib were approved by the U.S. Food and Drug Administration for treating patients with AD. Accordingly, the present study reviewed the role of JAK–STAT pathways in the pathogenesis of AD and explored updated applications of JAK inhibitors in treating AD.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1068260/fullatopic dermatitis (AD)Janus kinase (JAK)Janus kinase inhibitorsignal transducer and activator of transcription (STAT)review |
| spellingShingle | I-Hsin Huang I-Hsin Huang I-Hsin Huang Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Po-Chien Wu Po-Chien Wu Po-Chien Wu Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review Frontiers in Immunology atopic dermatitis (AD) Janus kinase (JAK) Janus kinase inhibitor signal transducer and activator of transcription (STAT) review |
| title | JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review |
| title_full | JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review |
| title_fullStr | JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review |
| title_full_unstemmed | JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review |
| title_short | JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review |
| title_sort | jak stat signaling pathway in the pathogenesis of atopic dermatitis an updated review |
| topic | atopic dermatitis (AD) Janus kinase (JAK) Janus kinase inhibitor signal transducer and activator of transcription (STAT) review |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1068260/full |
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