An improved partial synthesis of corosolic acid and its conversion to highly cytotoxic mitocans

Ursolic acid was used as a convenient starting material for a three-step partial synthesis of corosolic acid. Corosolic acid was acetylated, and an amide linker was attached followed by a rhodamine B unit at the distal end of the linker. Especially compounds holding a piperazinyl or homopiperazinyl...

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Bibliographic Details
Main Authors: Niels V. Heise, Sophie Hoenke, Immo Serbian, René Csuk
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417422000450