Phytochemicals as Therapeutic Interventions in Peripheral Artery Disease
Peripheral artery disease (PAD) affects over 200 million people worldwide, resulting in significant morbidity and mortality, yet treatment options remain limited. Among the manifestations of PAD is a severe functional disability and decline, which is thought to be the result of different pathophysio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/7/2143 |
| _version_ | 1797529157384536064 |
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| author | Ahmed Ismaeel K. Leigh Greathouse Nathan Newton Dimitrios Miserlis Evlampia Papoutsi Robert S. Smith Jack L. Eidson David L. Dawson Craig W. Milner Robert J. Widmer William T. Bohannon Panagiotis Koutakis |
| author_facet | Ahmed Ismaeel K. Leigh Greathouse Nathan Newton Dimitrios Miserlis Evlampia Papoutsi Robert S. Smith Jack L. Eidson David L. Dawson Craig W. Milner Robert J. Widmer William T. Bohannon Panagiotis Koutakis |
| author_sort | Ahmed Ismaeel |
| collection | DOAJ |
| description | Peripheral artery disease (PAD) affects over 200 million people worldwide, resulting in significant morbidity and mortality, yet treatment options remain limited. Among the manifestations of PAD is a severe functional disability and decline, which is thought to be the result of different pathophysiological mechanisms including oxidative stress, skeletal muscle pathology, and reduced nitric oxide bioavailability. Thus, compounds that target these mechanisms may have a therapeutic effect on walking performance in PAD patients. Phytochemicals produced by plants have been widely studied for their potential health effects and role in various diseases including cardiovascular disease and cancer. In this review, we focus on PAD and discuss the evidence related to the clinical utility of different phytochemicals. We discuss phytochemical research in preclinical models of PAD, and we highlight the results of the available clinical trials that have assessed the effects of these compounds on PAD patient functional outcomes. |
| first_indexed | 2024-03-10T10:09:45Z |
| format | Article |
| id | doaj.art-6d97c9cd1719425f96e29e2b58daebd1 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T10:09:45Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-6d97c9cd1719425f96e29e2b58daebd12023-11-22T01:16:46ZengMDPI AGNutrients2072-66432021-06-01137214310.3390/nu13072143Phytochemicals as Therapeutic Interventions in Peripheral Artery DiseaseAhmed Ismaeel0K. Leigh Greathouse1Nathan Newton2Dimitrios Miserlis3Evlampia Papoutsi4Robert S. Smith5Jack L. Eidson6David L. Dawson7Craig W. Milner8Robert J. Widmer9William T. Bohannon10Panagiotis Koutakis11Department of Biology, Baylor University, Waco, TX 76798, USADepartment of Biology, Baylor University, Waco, TX 76798, USADepartment of Chemistry and Biochemistry, Baylor University, Waco, TX 76798, USADepartment of Surgery, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USADepartment of Biology, Baylor University, Waco, TX 76798, USADepartment of Surgery, Baylor Scott & White Medical Center, Temple, TX 76508, USADepartment of Surgery, Baylor Scott & White Medical Center, Temple, TX 76508, USADepartment of Surgery, Baylor Scott & White Medical Center, Temple, TX 76508, USADepartment of Surgery, Baylor Scott & White Medical Center, Temple, TX 76508, USAHeart & Vascular Department, Baylor Scott & White Medical Center, Temple, TX 76508, USADepartment of Surgery, Baylor Scott & White Medical Center, Temple, TX 76508, USADepartment of Biology, Baylor University, Waco, TX 76798, USAPeripheral artery disease (PAD) affects over 200 million people worldwide, resulting in significant morbidity and mortality, yet treatment options remain limited. Among the manifestations of PAD is a severe functional disability and decline, which is thought to be the result of different pathophysiological mechanisms including oxidative stress, skeletal muscle pathology, and reduced nitric oxide bioavailability. Thus, compounds that target these mechanisms may have a therapeutic effect on walking performance in PAD patients. Phytochemicals produced by plants have been widely studied for their potential health effects and role in various diseases including cardiovascular disease and cancer. In this review, we focus on PAD and discuss the evidence related to the clinical utility of different phytochemicals. We discuss phytochemical research in preclinical models of PAD, and we highlight the results of the available clinical trials that have assessed the effects of these compounds on PAD patient functional outcomes.https://www.mdpi.com/2072-6643/13/7/2143polyphenolsbeetrootcocoaflavonolsclaudicationhindlimb ischemia |
| spellingShingle | Ahmed Ismaeel K. Leigh Greathouse Nathan Newton Dimitrios Miserlis Evlampia Papoutsi Robert S. Smith Jack L. Eidson David L. Dawson Craig W. Milner Robert J. Widmer William T. Bohannon Panagiotis Koutakis Phytochemicals as Therapeutic Interventions in Peripheral Artery Disease Nutrients polyphenols beetroot cocoa flavonols claudication hindlimb ischemia |
| title | Phytochemicals as Therapeutic Interventions in Peripheral Artery Disease |
| title_full | Phytochemicals as Therapeutic Interventions in Peripheral Artery Disease |
| title_fullStr | Phytochemicals as Therapeutic Interventions in Peripheral Artery Disease |
| title_full_unstemmed | Phytochemicals as Therapeutic Interventions in Peripheral Artery Disease |
| title_short | Phytochemicals as Therapeutic Interventions in Peripheral Artery Disease |
| title_sort | phytochemicals as therapeutic interventions in peripheral artery disease |
| topic | polyphenols beetroot cocoa flavonols claudication hindlimb ischemia |
| url | https://www.mdpi.com/2072-6643/13/7/2143 |
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