Associations between fetal or infancy pet exposure and food allergies: The Japan Environment and Children's Study.
The hygiene hypothesis suggests that pet exposure is effective in preventing allergic disease, and some studies have reported the beneficial effects of dog exposure during fetal development or early infancy on food allergy. However, the effects of exposure to pets other than dogs on the kinds of foo...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0282725 |
| _version_ | 1797842914163818496 |
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| author | Hisao Okabe Koichi Hashimoto Mika Yamada Takashi Ono Kazufumi Yaginuma Yohei Kume Mina Chishiki Akiko Sato Yuka Ogata Karin Imaizumi Tsuyoshi Murata Hyo Kyozuka Kosei Shinoki Seiji Yasumura Hidekazu Nishigori Keiya Fujimori Mitsuaki Hosoya Japan Environment and Children’s Study (JECS) |
| author_facet | Hisao Okabe Koichi Hashimoto Mika Yamada Takashi Ono Kazufumi Yaginuma Yohei Kume Mina Chishiki Akiko Sato Yuka Ogata Karin Imaizumi Tsuyoshi Murata Hyo Kyozuka Kosei Shinoki Seiji Yasumura Hidekazu Nishigori Keiya Fujimori Mitsuaki Hosoya Japan Environment and Children’s Study (JECS) |
| author_sort | Hisao Okabe |
| collection | DOAJ |
| description | The hygiene hypothesis suggests that pet exposure is effective in preventing allergic disease, and some studies have reported the beneficial effects of dog exposure during fetal development or early infancy on food allergy. However, the effects of exposure to pets other than dogs on the kinds of food allergies remains unaddressed. This study aimed to explore the effect of exposure to various species of pets on the risk of food allergies. We obtained information on pet exposure and food allergy from the Japan Environment and Children's Study, a nationwide, prospective birth cohort study that included 97,413 mothers and their children. We examined the associations between exposure to various species of pets during fetal development or early infancy and the incidence risk of food allergies. We conducted logistic regression analysis for each pet species, causative food, and timing of exposure. Exposure to dogs or cats during fetal development or early infancy was estimated to reduce the incidence risk of food allergies until the age of 3 years. Dog exposure was estimated to reduce the incidence risk of egg, milk, and nut allergies, and cat exposure was estimated to reduce the incidence risk of egg, wheat, and soybean allergies. However, hamster exposure was estimated to increase the incidence risk of nut allergy. In conclusion, the association between pet exposure and food allergies might differ depending on the pet species and causative food. Continued dog and cat exposure from fetal development to infancy was estimated to reduce the incidence risk of food allergies. The findings of this study shall aid in the design of future studies. |
| first_indexed | 2024-04-09T16:55:56Z |
| format | Article |
| id | doaj.art-6d98521f48a841dfadacfa5a6236218f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T16:55:56Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6d98521f48a841dfadacfa5a6236218f2023-04-21T05:35:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01183e028272510.1371/journal.pone.0282725Associations between fetal or infancy pet exposure and food allergies: The Japan Environment and Children's Study.Hisao OkabeKoichi HashimotoMika YamadaTakashi OnoKazufumi YaginumaYohei KumeMina ChishikiAkiko SatoYuka OgataKarin ImaizumiTsuyoshi MurataHyo KyozukaKosei ShinokiSeiji YasumuraHidekazu NishigoriKeiya FujimoriMitsuaki HosoyaJapan Environment and Children’s Study (JECS)The hygiene hypothesis suggests that pet exposure is effective in preventing allergic disease, and some studies have reported the beneficial effects of dog exposure during fetal development or early infancy on food allergy. However, the effects of exposure to pets other than dogs on the kinds of food allergies remains unaddressed. This study aimed to explore the effect of exposure to various species of pets on the risk of food allergies. We obtained information on pet exposure and food allergy from the Japan Environment and Children's Study, a nationwide, prospective birth cohort study that included 97,413 mothers and their children. We examined the associations between exposure to various species of pets during fetal development or early infancy and the incidence risk of food allergies. We conducted logistic regression analysis for each pet species, causative food, and timing of exposure. Exposure to dogs or cats during fetal development or early infancy was estimated to reduce the incidence risk of food allergies until the age of 3 years. Dog exposure was estimated to reduce the incidence risk of egg, milk, and nut allergies, and cat exposure was estimated to reduce the incidence risk of egg, wheat, and soybean allergies. However, hamster exposure was estimated to increase the incidence risk of nut allergy. In conclusion, the association between pet exposure and food allergies might differ depending on the pet species and causative food. Continued dog and cat exposure from fetal development to infancy was estimated to reduce the incidence risk of food allergies. The findings of this study shall aid in the design of future studies.https://doi.org/10.1371/journal.pone.0282725 |
| spellingShingle | Hisao Okabe Koichi Hashimoto Mika Yamada Takashi Ono Kazufumi Yaginuma Yohei Kume Mina Chishiki Akiko Sato Yuka Ogata Karin Imaizumi Tsuyoshi Murata Hyo Kyozuka Kosei Shinoki Seiji Yasumura Hidekazu Nishigori Keiya Fujimori Mitsuaki Hosoya Japan Environment and Children’s Study (JECS) Associations between fetal or infancy pet exposure and food allergies: The Japan Environment and Children's Study. PLoS ONE |
| title | Associations between fetal or infancy pet exposure and food allergies: The Japan Environment and Children's Study. |
| title_full | Associations between fetal or infancy pet exposure and food allergies: The Japan Environment and Children's Study. |
| title_fullStr | Associations between fetal or infancy pet exposure and food allergies: The Japan Environment and Children's Study. |
| title_full_unstemmed | Associations between fetal or infancy pet exposure and food allergies: The Japan Environment and Children's Study. |
| title_short | Associations between fetal or infancy pet exposure and food allergies: The Japan Environment and Children's Study. |
| title_sort | associations between fetal or infancy pet exposure and food allergies the japan environment and children s study |
| url | https://doi.org/10.1371/journal.pone.0282725 |
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