Efficacy of Low-Level Laser Therapy for Oral Mucositis in Hematologic Patients Undergoing Transplantation: A Single-Arm Prospective Study
Oral mucositis significantly affects the quality of life in hematologic cancer patients undergoing hematopoietic stem cell transplantation. Despite global evidence supporting the efficacy of low-level laser therapy (LLLT) for mucositis prevention, its clinical adoption in Japan is limited. This stud...
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MDPI AG
2023-11-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/11/1603 |
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| author | Hiromi Nishi Susumu Horikoshi Kouji Ohta Tetsumi Yoshida Noriyasu Fukushima Kyoko Oshita Syuichi Munenaga Taro Edahiro Hiroshi Ureshino Hideo Shigeishi Yukio Yoshioka Masaru Konishi Noriaki Ide Yuma Ogawa Rikou Marukawa Tomoaki Shintani Natumi Ino Mikihito Kajiya Naoya Kakimoto Hiroki Ohge Tatsuo Ichinohe Hiroyuki Kawaguchi |
| author_facet | Hiromi Nishi Susumu Horikoshi Kouji Ohta Tetsumi Yoshida Noriyasu Fukushima Kyoko Oshita Syuichi Munenaga Taro Edahiro Hiroshi Ureshino Hideo Shigeishi Yukio Yoshioka Masaru Konishi Noriaki Ide Yuma Ogawa Rikou Marukawa Tomoaki Shintani Natumi Ino Mikihito Kajiya Naoya Kakimoto Hiroki Ohge Tatsuo Ichinohe Hiroyuki Kawaguchi |
| author_sort | Hiromi Nishi |
| collection | DOAJ |
| description | Oral mucositis significantly affects the quality of life in hematologic cancer patients undergoing hematopoietic stem cell transplantation. Despite global evidence supporting the efficacy of low-level laser therapy (LLLT) for mucositis prevention, its clinical adoption in Japan is limited. This study aimed to fill this gap by evaluating the safety and efficacy of LLLT in a Japanese patient population. In a single-group, non-blinded, exploratory trial, we compared 21 LLLT-treated patients against a historical control of 96 patients. The primary endpoint was the incidence of Grade ≥ 2 mucositis, based on NCI-CTCAE ver. 4.0. The LLLT group showed a significantly lower incidence of Grade ≥ 2 mucositis (23.8%) compared to the control group (64.6%) (<i>p</i> = 0.0006). Furthermore, Grade ≥ 2 mucositis correlated with increased oral dryness and longer hospital stays. Our study confirms the efficacy of LLLT in reducing the onset of severe oral mucositis among Japanese hematologic cancer patients, advocating for its clinical introduction as a preventive measure in Japan. |
| first_indexed | 2024-03-09T16:41:06Z |
| format | Article |
| id | doaj.art-6d98765415d14a628c0b8c97c775821e |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T16:41:06Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-6d98765415d14a628c0b8c97c775821e2023-11-24T14:51:35ZengMDPI AGJournal of Personalized Medicine2075-44262023-11-011311160310.3390/jpm13111603Efficacy of Low-Level Laser Therapy for Oral Mucositis in Hematologic Patients Undergoing Transplantation: A Single-Arm Prospective StudyHiromi Nishi0Susumu Horikoshi1Kouji Ohta2Tetsumi Yoshida3Noriyasu Fukushima4Kyoko Oshita5Syuichi Munenaga6Taro Edahiro7Hiroshi Ureshino8Hideo Shigeishi9Yukio Yoshioka10Masaru Konishi11Noriaki Ide12Yuma Ogawa13Rikou Marukawa14Tomoaki Shintani15Natumi Ino16Mikihito Kajiya17Naoya Kakimoto18Hiroki Ohge19Tatsuo Ichinohe20Hiroyuki Kawaguchi21Department of General Dentistry, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-Ku, Hiroshima 734-8551, JapanDepartment of General Dentistry, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-Ku, Hiroshima 734-8551, JapanDepartment of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Internal Medicine, Karatsu Red Cross Hospital, Karatsu 847-8588, JapanDepartment of Anesthesiology, Hiroshima General Hospital, Hiroshima 734-8551, JapanDepartment of General Dentistry, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-Ku, Hiroshima 734-8551, JapanDepartment of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Oral and Maxillofacial Radiology, Hiroshima University Hospital, Hiroshima 734-8551, JapanDepartment of General Dentistry, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-Ku, Hiroshima 734-8551, JapanDepartment of Program of Dentistry, School of Dentistry, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Program of Dentistry, School of Dentistry, Hiroshima University, Hiroshima 734-8551, JapanCenter of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima 734-8551, JapanDepartment of Clinical Practice and Support, Hiroshima University Hospital, Hiroshima 734-8551, JapanCenter of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima 734-8551, JapanDepartment of Oral and Maxillofacial Radiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Infectious Diseases, Hiroshima University Hospital, Hiroshima 734-8551, JapanDepartment of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8551, JapanDepartment of General Dentistry, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-Ku, Hiroshima 734-8551, JapanOral mucositis significantly affects the quality of life in hematologic cancer patients undergoing hematopoietic stem cell transplantation. Despite global evidence supporting the efficacy of low-level laser therapy (LLLT) for mucositis prevention, its clinical adoption in Japan is limited. This study aimed to fill this gap by evaluating the safety and efficacy of LLLT in a Japanese patient population. In a single-group, non-blinded, exploratory trial, we compared 21 LLLT-treated patients against a historical control of 96 patients. The primary endpoint was the incidence of Grade ≥ 2 mucositis, based on NCI-CTCAE ver. 4.0. The LLLT group showed a significantly lower incidence of Grade ≥ 2 mucositis (23.8%) compared to the control group (64.6%) (<i>p</i> = 0.0006). Furthermore, Grade ≥ 2 mucositis correlated with increased oral dryness and longer hospital stays. Our study confirms the efficacy of LLLT in reducing the onset of severe oral mucositis among Japanese hematologic cancer patients, advocating for its clinical introduction as a preventive measure in Japan.https://www.mdpi.com/2075-4426/13/11/1603oral mucositishematopoietic stem cell transplantationlow-level light therapyquality of lifeJapan |
| spellingShingle | Hiromi Nishi Susumu Horikoshi Kouji Ohta Tetsumi Yoshida Noriyasu Fukushima Kyoko Oshita Syuichi Munenaga Taro Edahiro Hiroshi Ureshino Hideo Shigeishi Yukio Yoshioka Masaru Konishi Noriaki Ide Yuma Ogawa Rikou Marukawa Tomoaki Shintani Natumi Ino Mikihito Kajiya Naoya Kakimoto Hiroki Ohge Tatsuo Ichinohe Hiroyuki Kawaguchi Efficacy of Low-Level Laser Therapy for Oral Mucositis in Hematologic Patients Undergoing Transplantation: A Single-Arm Prospective Study Journal of Personalized Medicine oral mucositis hematopoietic stem cell transplantation low-level light therapy quality of life Japan |
| title | Efficacy of Low-Level Laser Therapy for Oral Mucositis in Hematologic Patients Undergoing Transplantation: A Single-Arm Prospective Study |
| title_full | Efficacy of Low-Level Laser Therapy for Oral Mucositis in Hematologic Patients Undergoing Transplantation: A Single-Arm Prospective Study |
| title_fullStr | Efficacy of Low-Level Laser Therapy for Oral Mucositis in Hematologic Patients Undergoing Transplantation: A Single-Arm Prospective Study |
| title_full_unstemmed | Efficacy of Low-Level Laser Therapy for Oral Mucositis in Hematologic Patients Undergoing Transplantation: A Single-Arm Prospective Study |
| title_short | Efficacy of Low-Level Laser Therapy for Oral Mucositis in Hematologic Patients Undergoing Transplantation: A Single-Arm Prospective Study |
| title_sort | efficacy of low level laser therapy for oral mucositis in hematologic patients undergoing transplantation a single arm prospective study |
| topic | oral mucositis hematopoietic stem cell transplantation low-level light therapy quality of life Japan |
| url | https://www.mdpi.com/2075-4426/13/11/1603 |
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