Elevated D-Dimer Levels Predict a Poor Outcome in Critically Ill Patients
D-dimer is a biomarker of thrombosis and recently been considered to predict a poor outcome in patients with infectious diseases. Plasma D-dimer levels were measured in critically ill patients to examine their relationship with the poor outcome. The plasma D-dimer levels were markedly higher in the...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-12-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/1076029620973084 |
| _version_ | 1818589443098935296 |
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| author | Yuhuko Ichkawa Ms Hideo Wada MD, PhD Minoru Ezaki Mr Motoko Tanaka Shinya Hiromori Katsuya Shiraki MD, PhD Isao Moritani MD, PhD Akitaka Yamamoto MD, PhD Haruhiko Tashiro MD, PhD Hideto Shimpo MD, PhD Motomu Shimaoka |
| author_facet | Yuhuko Ichkawa Ms Hideo Wada MD, PhD Minoru Ezaki Mr Motoko Tanaka Shinya Hiromori Katsuya Shiraki MD, PhD Isao Moritani MD, PhD Akitaka Yamamoto MD, PhD Haruhiko Tashiro MD, PhD Hideto Shimpo MD, PhD Motomu Shimaoka |
| author_sort | Yuhuko Ichkawa Ms |
| collection | DOAJ |
| description | D-dimer is a biomarker of thrombosis and recently been considered to predict a poor outcome in patients with infectious diseases. Plasma D-dimer levels were measured in critically ill patients to examine their relationship with the poor outcome. The plasma D-dimer levels were markedly higher in the patients with various underlying disease especially venous thromboembolism in comparison to those without severe underlying diseases. The plasma D-dimer levels in non-survivors were significantly higher than those in survivors. In a receiver operating characteristic analysis, the area under the curve was high for the disseminated intravascular coagulation (DIC) score, the D-dimer value, and the prothrombin time-international normalize ratio (PT-INR). Adequate cut-off values for predicting the outcome were 3 as follows: DIC score, 3 points; D-dimer, 4.2 mg/L; and PT-INR, 1.08. D-dimer, which is a biomarker for thrombosis, is increased in various underlying diseases and predicts a poor outcome. |
| first_indexed | 2024-12-16T09:40:43Z |
| format | Article |
| id | doaj.art-6d99548f905d458a95999f7484994c16 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-12-16T09:40:43Z |
| publishDate | 2020-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-6d99548f905d458a95999f7484994c162022-12-21T22:36:17ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232020-12-012610.1177/1076029620973084Elevated D-Dimer Levels Predict a Poor Outcome in Critically Ill PatientsYuhuko Ichkawa Ms0Hideo Wada MD, PhD1Minoru Ezaki Mr2Motoko Tanaka3Shinya Hiromori4Katsuya Shiraki MD, PhD5Isao Moritani MD, PhD6Akitaka Yamamoto MD, PhD7Haruhiko Tashiro MD, PhD8Hideto Shimpo MD, PhD9Motomu Shimaoka10 Department of Central Laboratory, , Yokkaichi, Japan Associated Department with Mie Graduate School of Medicine, Tsu, Japan Department of Central Laboratory, , Yokkaichi, Japan Department of Central Laboratory, , Yokkaichi, Japan Department of Central Laboratory, , Yokkaichi, Japan Associated Department with Mie Graduate School of Medicine, Tsu, Japan Department of General Medicine, , Yokkaichi, Japan Department of Emergency and Critical Care Center, , Yokkaichi, Japan Department of Emergency and Critical Care Center, , Yokkaichi, Japan , Yokkaichi, Japan Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, JapanD-dimer is a biomarker of thrombosis and recently been considered to predict a poor outcome in patients with infectious diseases. Plasma D-dimer levels were measured in critically ill patients to examine their relationship with the poor outcome. The plasma D-dimer levels were markedly higher in the patients with various underlying disease especially venous thromboembolism in comparison to those without severe underlying diseases. The plasma D-dimer levels in non-survivors were significantly higher than those in survivors. In a receiver operating characteristic analysis, the area under the curve was high for the disseminated intravascular coagulation (DIC) score, the D-dimer value, and the prothrombin time-international normalize ratio (PT-INR). Adequate cut-off values for predicting the outcome were 3 as follows: DIC score, 3 points; D-dimer, 4.2 mg/L; and PT-INR, 1.08. D-dimer, which is a biomarker for thrombosis, is increased in various underlying diseases and predicts a poor outcome.https://doi.org/10.1177/1076029620973084 |
| spellingShingle | Yuhuko Ichkawa Ms Hideo Wada MD, PhD Minoru Ezaki Mr Motoko Tanaka Shinya Hiromori Katsuya Shiraki MD, PhD Isao Moritani MD, PhD Akitaka Yamamoto MD, PhD Haruhiko Tashiro MD, PhD Hideto Shimpo MD, PhD Motomu Shimaoka Elevated D-Dimer Levels Predict a Poor Outcome in Critically Ill Patients Clinical and Applied Thrombosis/Hemostasis |
| title | Elevated D-Dimer Levels Predict a Poor Outcome in Critically Ill Patients |
| title_full | Elevated D-Dimer Levels Predict a Poor Outcome in Critically Ill Patients |
| title_fullStr | Elevated D-Dimer Levels Predict a Poor Outcome in Critically Ill Patients |
| title_full_unstemmed | Elevated D-Dimer Levels Predict a Poor Outcome in Critically Ill Patients |
| title_short | Elevated D-Dimer Levels Predict a Poor Outcome in Critically Ill Patients |
| title_sort | elevated d dimer levels predict a poor outcome in critically ill patients |
| url | https://doi.org/10.1177/1076029620973084 |
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