Ferroptosis: A new insight for treatment of acute kidney injury
Acute kidney injury (AKI), one of the most prevalent clinical diseases with a high incidence rate worldwide, is characterized by a rapid deterioration of renal function and further triggers the accumulation of metabolic waste and toxins, leading to complications and dysfunction of other organs. Mult...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1065867/full |
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| author | Shiyang Li Shiyang Li Shiyang Li Shiyang Li Rui Wang Rui Wang Rui Wang Rui Wang Yixue Wang Yixue Wang Yixue Wang Yixue Wang Yong Liu Yong Liu Yong Liu Yong Liu Yingjin Qiao Peipei Li Peipei Li Peipei Li Peipei Li Jingfang Chen Jingfang Chen Jingfang Chen Jingfang Chen Shaokang Pan Shaokang Pan Shaokang Pan Shaokang Pan Qi Feng Qi Feng Qi Feng Qi Feng Zhangsuo Liu Zhangsuo Liu Zhangsuo Liu Zhangsuo Liu Dongwei Liu Dongwei Liu Dongwei Liu Dongwei Liu |
| author_facet | Shiyang Li Shiyang Li Shiyang Li Shiyang Li Rui Wang Rui Wang Rui Wang Rui Wang Yixue Wang Yixue Wang Yixue Wang Yixue Wang Yong Liu Yong Liu Yong Liu Yong Liu Yingjin Qiao Peipei Li Peipei Li Peipei Li Peipei Li Jingfang Chen Jingfang Chen Jingfang Chen Jingfang Chen Shaokang Pan Shaokang Pan Shaokang Pan Shaokang Pan Qi Feng Qi Feng Qi Feng Qi Feng Zhangsuo Liu Zhangsuo Liu Zhangsuo Liu Zhangsuo Liu Dongwei Liu Dongwei Liu Dongwei Liu Dongwei Liu |
| author_sort | Shiyang Li |
| collection | DOAJ |
| description | Acute kidney injury (AKI), one of the most prevalent clinical diseases with a high incidence rate worldwide, is characterized by a rapid deterioration of renal function and further triggers the accumulation of metabolic waste and toxins, leading to complications and dysfunction of other organs. Multiple pathogenic factors, such as rhabdomyolysis, infection, nephrotoxic medications, and ischemia-reperfusion injury, contribute to the onset and progression of AKI. However, the detailed mechanism remains unclear. Ferroptosis, a recently identified mechanism of nonapoptotic cell death, is iron-dependent and caused by lipid peroxide accumulation in cells. A variety of studies have demonstrated that ferroptosis plays a significant role in AKI development, in contrast to other forms of cell death, such as apoptosis, necroptosis, and pyroptosis. In this review, we systemically summarized the definition, primary biochemical mechanisms, key regulators and associated pharmacological research progress of ferroptosis in AKI. We further discussed its therapeutic potential for the prevention of AKI, in the hope of providing a useful reference for further basic and clinical studies. |
| first_indexed | 2024-04-12T08:54:57Z |
| format | Article |
| id | doaj.art-6d9d1fa1efa9432c84d61e654929ecca |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T08:54:57Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-6d9d1fa1efa9432c84d61e654929ecca2022-12-22T03:39:24ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-11-011310.3389/fphar.2022.10658671065867Ferroptosis: A new insight for treatment of acute kidney injuryShiyang Li0Shiyang Li1Shiyang Li2Shiyang Li3Rui Wang4Rui Wang5Rui Wang6Rui Wang7Yixue Wang8Yixue Wang9Yixue Wang10Yixue Wang11Yong Liu12Yong Liu13Yong Liu14Yong Liu15Yingjin Qiao16Peipei Li17Peipei Li18Peipei Li19Peipei Li20Jingfang Chen21Jingfang Chen22Jingfang Chen23Jingfang Chen24Shaokang Pan25Shaokang Pan26Shaokang Pan27Shaokang Pan28Qi Feng29Qi Feng30Qi Feng31Qi Feng32Zhangsuo Liu33Zhangsuo Liu34Zhangsuo Liu35Zhangsuo Liu36Dongwei Liu37Dongwei Liu38Dongwei Liu39Dongwei Liu40Traditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaResearch Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaHenan Province Research Center for Kidney Disease, Zhengzhou, ChinaKey Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, ChinaTraditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaResearch Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaHenan Province Research Center for Kidney Disease, Zhengzhou, ChinaKey Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, ChinaTraditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaResearch Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaHenan Province Research Center for Kidney Disease, Zhengzhou, ChinaKey Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, ChinaTraditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaResearch Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaHenan Province Research Center for Kidney Disease, Zhengzhou, ChinaKey Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, ChinaBlood Purification Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaTraditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaResearch Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaHenan Province Research Center for Kidney Disease, Zhengzhou, ChinaKey Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, ChinaTraditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaResearch Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaHenan Province Research Center for Kidney Disease, Zhengzhou, ChinaKey Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, ChinaTraditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaResearch Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaHenan Province Research Center for Kidney Disease, Zhengzhou, ChinaKey Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, ChinaTraditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaResearch Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaHenan Province Research Center for Kidney Disease, Zhengzhou, ChinaKey Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, ChinaTraditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaResearch Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaHenan Province Research Center for Kidney Disease, Zhengzhou, ChinaKey Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, ChinaTraditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaResearch Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaHenan Province Research Center for Kidney Disease, Zhengzhou, ChinaKey Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, ChinaAcute kidney injury (AKI), one of the most prevalent clinical diseases with a high incidence rate worldwide, is characterized by a rapid deterioration of renal function and further triggers the accumulation of metabolic waste and toxins, leading to complications and dysfunction of other organs. Multiple pathogenic factors, such as rhabdomyolysis, infection, nephrotoxic medications, and ischemia-reperfusion injury, contribute to the onset and progression of AKI. However, the detailed mechanism remains unclear. Ferroptosis, a recently identified mechanism of nonapoptotic cell death, is iron-dependent and caused by lipid peroxide accumulation in cells. A variety of studies have demonstrated that ferroptosis plays a significant role in AKI development, in contrast to other forms of cell death, such as apoptosis, necroptosis, and pyroptosis. In this review, we systemically summarized the definition, primary biochemical mechanisms, key regulators and associated pharmacological research progress of ferroptosis in AKI. We further discussed its therapeutic potential for the prevention of AKI, in the hope of providing a useful reference for further basic and clinical studies.https://www.frontiersin.org/articles/10.3389/fphar.2022.1065867/fullacute kidney injuryferroptosismechanismsregulatorstreatment |
| spellingShingle | Shiyang Li Shiyang Li Shiyang Li Shiyang Li Rui Wang Rui Wang Rui Wang Rui Wang Yixue Wang Yixue Wang Yixue Wang Yixue Wang Yong Liu Yong Liu Yong Liu Yong Liu Yingjin Qiao Peipei Li Peipei Li Peipei Li Peipei Li Jingfang Chen Jingfang Chen Jingfang Chen Jingfang Chen Shaokang Pan Shaokang Pan Shaokang Pan Shaokang Pan Qi Feng Qi Feng Qi Feng Qi Feng Zhangsuo Liu Zhangsuo Liu Zhangsuo Liu Zhangsuo Liu Dongwei Liu Dongwei Liu Dongwei Liu Dongwei Liu Ferroptosis: A new insight for treatment of acute kidney injury Frontiers in Pharmacology acute kidney injury ferroptosis mechanisms regulators treatment |
| title | Ferroptosis: A new insight for treatment of acute kidney injury |
| title_full | Ferroptosis: A new insight for treatment of acute kidney injury |
| title_fullStr | Ferroptosis: A new insight for treatment of acute kidney injury |
| title_full_unstemmed | Ferroptosis: A new insight for treatment of acute kidney injury |
| title_short | Ferroptosis: A new insight for treatment of acute kidney injury |
| title_sort | ferroptosis a new insight for treatment of acute kidney injury |
| topic | acute kidney injury ferroptosis mechanisms regulators treatment |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1065867/full |
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