Association between Fasting Glucose Concentration, Lipid Profile and 25(OH)D Status in Children Aged 9–11
Background: The aim of this study was to assess the relationship between vitamin D status and the prevalence of dyslipidemia and impaired fasting glucose (IFG) in children. Methods and Summary: 284 children (150 boys and 134 girls) aged 9–11 were included in the study. Children with defici...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-09-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6643/10/10/1359 |
| _version_ | 1811236182959325184 |
|---|---|
| author | Lukasz Szternel Magdalena Krintus Katarzyna Bergmann Tadeusz Derezinski Grazyna Sypniewska |
| author_facet | Lukasz Szternel Magdalena Krintus Katarzyna Bergmann Tadeusz Derezinski Grazyna Sypniewska |
| author_sort | Lukasz Szternel |
| collection | DOAJ |
| description | Background: The aim of this study was to assess the relationship between vitamin D status and the prevalence of dyslipidemia and impaired fasting glucose (IFG) in children. Methods and Summary: 284 children (150 boys and 134 girls) aged 9–11 were included in the study. Children with deficient 25(OH)D (25-hydroxycholecalciferol) levels ≤20 ng/mL (50 nmol/L) were characterized by a more frequent occurrence of impaired fasting glucose (IFG) (Odd ratios (OR) = 1.966, 95% confidence interval (CI): 1.055–3.663; p = 0.033) when compared to children with 25(OH)D >20 ng/mL. Serum 25(OH)D with concentration lower by 1 ng/mL (2.5 nmol/L) was linked to higher fasting glucose (by 0.25 mg/dL, 0.013 mmol/L; p = 0.017), higher total cholesterol (TC) by almost 1 mg/dL (0.96 mg/dL, 0.25 mmol/L; p = 0.006) and higher high-density lipoprotein cholesterol (HDL-C) (by 0.57 mg/dL, 0.015 mmol/L; p < 0.001). Conclusion: 25(OH)D deficiency may negatively affect fasting glucose and total cholesterol concentration in children aged 9–11. Vitamin D-deficient children are twice as likely to develop prediabetes as reflected by impaired fasting glucose when compared to those with a 25(OH)D level above 20 ng/mL (50 nmol/L). |
| first_indexed | 2024-04-12T12:04:35Z |
| format | Article |
| id | doaj.art-6d9e521197db4154acbefa76ffc24aa0 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-12T12:04:35Z |
| publishDate | 2018-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-6d9e521197db4154acbefa76ffc24aa02022-12-22T03:33:45ZengMDPI AGNutrients2072-66432018-09-011010135910.3390/nu10101359nu10101359Association between Fasting Glucose Concentration, Lipid Profile and 25(OH)D Status in Children Aged 9–11Lukasz Szternel0Magdalena Krintus1Katarzyna Bergmann2Tadeusz Derezinski3Grazyna Sypniewska4Department of Laboratory Medicine, Nicolaus Copernicus University, Collegium Medicum, 85094 Bydgoszcz, PolandDepartment of Laboratory Medicine, Nicolaus Copernicus University, Collegium Medicum, 85094 Bydgoszcz, PolandDepartment of Laboratory Medicine, Nicolaus Copernicus University, Collegium Medicum, 85094 Bydgoszcz, PolandOutpatient Clinic, “Esculap”, 88140 Gniewkowo, PolandDepartment of Laboratory Medicine, Nicolaus Copernicus University, Collegium Medicum, 85094 Bydgoszcz, PolandBackground: The aim of this study was to assess the relationship between vitamin D status and the prevalence of dyslipidemia and impaired fasting glucose (IFG) in children. Methods and Summary: 284 children (150 boys and 134 girls) aged 9–11 were included in the study. Children with deficient 25(OH)D (25-hydroxycholecalciferol) levels ≤20 ng/mL (50 nmol/L) were characterized by a more frequent occurrence of impaired fasting glucose (IFG) (Odd ratios (OR) = 1.966, 95% confidence interval (CI): 1.055–3.663; p = 0.033) when compared to children with 25(OH)D >20 ng/mL. Serum 25(OH)D with concentration lower by 1 ng/mL (2.5 nmol/L) was linked to higher fasting glucose (by 0.25 mg/dL, 0.013 mmol/L; p = 0.017), higher total cholesterol (TC) by almost 1 mg/dL (0.96 mg/dL, 0.25 mmol/L; p = 0.006) and higher high-density lipoprotein cholesterol (HDL-C) (by 0.57 mg/dL, 0.015 mmol/L; p < 0.001). Conclusion: 25(OH)D deficiency may negatively affect fasting glucose and total cholesterol concentration in children aged 9–11. Vitamin D-deficient children are twice as likely to develop prediabetes as reflected by impaired fasting glucose when compared to those with a 25(OH)D level above 20 ng/mL (50 nmol/L).http://www.mdpi.com/2072-6643/10/10/135925(OH)D deficiencychildrenimpaired fasting glucosehypercholesterolemia |
| spellingShingle | Lukasz Szternel Magdalena Krintus Katarzyna Bergmann Tadeusz Derezinski Grazyna Sypniewska Association between Fasting Glucose Concentration, Lipid Profile and 25(OH)D Status in Children Aged 9–11 Nutrients 25(OH)D deficiency children impaired fasting glucose hypercholesterolemia |
| title | Association between Fasting Glucose Concentration, Lipid Profile and 25(OH)D Status in Children Aged 9–11 |
| title_full | Association between Fasting Glucose Concentration, Lipid Profile and 25(OH)D Status in Children Aged 9–11 |
| title_fullStr | Association between Fasting Glucose Concentration, Lipid Profile and 25(OH)D Status in Children Aged 9–11 |
| title_full_unstemmed | Association between Fasting Glucose Concentration, Lipid Profile and 25(OH)D Status in Children Aged 9–11 |
| title_short | Association between Fasting Glucose Concentration, Lipid Profile and 25(OH)D Status in Children Aged 9–11 |
| title_sort | association between fasting glucose concentration lipid profile and 25 oh d status in children aged 9 11 |
| topic | 25(OH)D deficiency children impaired fasting glucose hypercholesterolemia |
| url | http://www.mdpi.com/2072-6643/10/10/1359 |
| work_keys_str_mv | AT lukaszszternel associationbetweenfastingglucoseconcentrationlipidprofileand25ohdstatusinchildrenaged911 AT magdalenakrintus associationbetweenfastingglucoseconcentrationlipidprofileand25ohdstatusinchildrenaged911 AT katarzynabergmann associationbetweenfastingglucoseconcentrationlipidprofileand25ohdstatusinchildrenaged911 AT tadeuszderezinski associationbetweenfastingglucoseconcentrationlipidprofileand25ohdstatusinchildrenaged911 AT grazynasypniewska associationbetweenfastingglucoseconcentrationlipidprofileand25ohdstatusinchildrenaged911 |