Infections in children with simple obesity: The relation to phagocytic function and serum leptin
Introduction: There is a possible association between obesity and infections. We sought to investigate phagocytic functions in obese children and their relation to serum leptin levels. Methods: A cross sectional, controlled study was conducted, comprising 40 cases with simple visceral-type obesity....
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Journal of Infection and Public Health |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034118301369 |
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| author | Nadin N. Toaima Rasha H. El-Owaidy Dina L. Zaki Lerine B. Eldin |
| author_facet | Nadin N. Toaima Rasha H. El-Owaidy Dina L. Zaki Lerine B. Eldin |
| author_sort | Nadin N. Toaima |
| collection | DOAJ |
| description | Introduction: There is a possible association between obesity and infections. We sought to investigate phagocytic functions in obese children and their relation to serum leptin levels. Methods: A cross sectional, controlled study was conducted, comprising 40 cases with simple visceral-type obesity. Subjects were evaluated for percentage of caloric intake, frequency and type of infections, body mass index (BMI) z score, in addition to complete blood counting, serum leptin assay (ELISA) and Dihydrorhodamine (DHR) flowcytometry. Results: Cases were 21 males (52.5%) and 19 females (47.5%) with mean age 7.14 years ± 2.73 SD with median duration of obesity 4.2 years (IQR: 2–6). Cases had higher frequency of infections compared with controls (p < 0.001). Serum leptin was significantly higher among cases (t = −12.391, p < 0.001), while DHR results were comparable in the studied groups (p = 0.067). Among cases, absolute lymphocytic count (ALC) correlated negatively with percentage of total caloric intake (p = 0.045). Leptin levels correlated positively with frequency of infections (p = 0.019) but negatively with ALC (p = 0.043). DHR results showed weak negative correlations with serum leptin (p = 0.177) and with BMI Z score (p = 0.109). Conclusion: Obese children are posed at increased risk of infections and have higher serum leptin levels with possible negative effects of leptin on phagocytic functions. Keywords: Obesity, Phagocytic function, Leptin, Infections, Calories |
| first_indexed | 2024-12-22T15:55:28Z |
| format | Article |
| id | doaj.art-6d9f8f1984364c9abd3d395f870d27c9 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-12-22T15:55:28Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-6d9f8f1984364c9abd3d395f870d27c92022-12-21T18:20:48ZengElsevierJournal of Infection and Public Health1876-03412019-01-011215761Infections in children with simple obesity: The relation to phagocytic function and serum leptinNadin N. Toaima0Rasha H. El-Owaidy1Dina L. Zaki2Lerine B. Eldin3Pediatric Endocrine Unit, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, EgyptPediatric Allergy and Immunology Unit, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Corresponding author at: Department of Pediatric Allergy and Immunology, Faculty of Medicine, Ain-Shams University, Abbassya square, Cairo, 11566, Egypt.Egyptian Ministry of Health Hospital, Cairo, EgyptPediatric Endocrine Unit, Children’s Hospital, Faculty of Medicine, Ain Shams University, Cairo, EgyptIntroduction: There is a possible association between obesity and infections. We sought to investigate phagocytic functions in obese children and their relation to serum leptin levels. Methods: A cross sectional, controlled study was conducted, comprising 40 cases with simple visceral-type obesity. Subjects were evaluated for percentage of caloric intake, frequency and type of infections, body mass index (BMI) z score, in addition to complete blood counting, serum leptin assay (ELISA) and Dihydrorhodamine (DHR) flowcytometry. Results: Cases were 21 males (52.5%) and 19 females (47.5%) with mean age 7.14 years ± 2.73 SD with median duration of obesity 4.2 years (IQR: 2–6). Cases had higher frequency of infections compared with controls (p < 0.001). Serum leptin was significantly higher among cases (t = −12.391, p < 0.001), while DHR results were comparable in the studied groups (p = 0.067). Among cases, absolute lymphocytic count (ALC) correlated negatively with percentage of total caloric intake (p = 0.045). Leptin levels correlated positively with frequency of infections (p = 0.019) but negatively with ALC (p = 0.043). DHR results showed weak negative correlations with serum leptin (p = 0.177) and with BMI Z score (p = 0.109). Conclusion: Obese children are posed at increased risk of infections and have higher serum leptin levels with possible negative effects of leptin on phagocytic functions. Keywords: Obesity, Phagocytic function, Leptin, Infections, Calorieshttp://www.sciencedirect.com/science/article/pii/S1876034118301369 |
| spellingShingle | Nadin N. Toaima Rasha H. El-Owaidy Dina L. Zaki Lerine B. Eldin Infections in children with simple obesity: The relation to phagocytic function and serum leptin Journal of Infection and Public Health |
| title | Infections in children with simple obesity: The relation to phagocytic function and serum leptin |
| title_full | Infections in children with simple obesity: The relation to phagocytic function and serum leptin |
| title_fullStr | Infections in children with simple obesity: The relation to phagocytic function and serum leptin |
| title_full_unstemmed | Infections in children with simple obesity: The relation to phagocytic function and serum leptin |
| title_short | Infections in children with simple obesity: The relation to phagocytic function and serum leptin |
| title_sort | infections in children with simple obesity the relation to phagocytic function and serum leptin |
| url | http://www.sciencedirect.com/science/article/pii/S1876034118301369 |
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