GLUT3 regulates alternative macrophage signaling through a glucose transport–independent role
Macrophages are key mediators of innate immunity whose functional state can be regulated by glucose transporters. Although abundantly expressed in macrophages, the specific function of GLUT3, an isoform of facilitative glucose transporters, has not been clearly established. In this issue of the JCI,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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American Society for Clinical Investigation
2023-11-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI174540 |
| _version_ | 1797634435848339456 |
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| author | Peng Zhang Jason Miska Amy B. Heimberger |
| author_facet | Peng Zhang Jason Miska Amy B. Heimberger |
| author_sort | Peng Zhang |
| collection | DOAJ |
| description | Macrophages are key mediators of innate immunity whose functional state can be regulated by glucose transporters. Although abundantly expressed in macrophages, the specific function of GLUT3, an isoform of facilitative glucose transporters, has not been clearly established. In this issue of the JCI, Dong-Min Yu and colleagues identify an alternative role for GLUT3 in promoting M2 macrophage polarization. The authors demonstrated that GLUT3 was upregulated upon M2 stimulation and was required for efficient alternative macrophage polarization and function. They further showed that GLUT3-induced M2 polarization was independent of glucose transport and functioned through Ras-mediated regulation of IL-4R endocytosis and IL-4/STAT6 activation. These findings may guide the development of macrophage-targeted treatments. |
| first_indexed | 2024-03-11T12:07:42Z |
| format | Article |
| id | doaj.art-6da00be9823a40a38420a43706d970ef |
| institution | Directory Open Access Journal |
| issn | 1558-8238 |
| language | English |
| last_indexed | 2024-03-11T12:07:42Z |
| publishDate | 2023-11-01 |
| publisher | American Society for Clinical Investigation |
| record_format | Article |
| series | The Journal of Clinical Investigation |
| spelling | doaj.art-6da00be9823a40a38420a43706d970ef2023-11-07T16:21:03ZengAmerican Society for Clinical InvestigationThe Journal of Clinical Investigation1558-82382023-11-0113321GLUT3 regulates alternative macrophage signaling through a glucose transport–independent rolePeng ZhangJason MiskaAmy B. HeimbergerMacrophages are key mediators of innate immunity whose functional state can be regulated by glucose transporters. Although abundantly expressed in macrophages, the specific function of GLUT3, an isoform of facilitative glucose transporters, has not been clearly established. In this issue of the JCI, Dong-Min Yu and colleagues identify an alternative role for GLUT3 in promoting M2 macrophage polarization. The authors demonstrated that GLUT3 was upregulated upon M2 stimulation and was required for efficient alternative macrophage polarization and function. They further showed that GLUT3-induced M2 polarization was independent of glucose transport and functioned through Ras-mediated regulation of IL-4R endocytosis and IL-4/STAT6 activation. These findings may guide the development of macrophage-targeted treatments.https://doi.org/10.1172/JCI174540 |
| spellingShingle | Peng Zhang Jason Miska Amy B. Heimberger GLUT3 regulates alternative macrophage signaling through a glucose transport–independent role The Journal of Clinical Investigation |
| title | GLUT3 regulates alternative macrophage signaling through a glucose transport–independent role |
| title_full | GLUT3 regulates alternative macrophage signaling through a glucose transport–independent role |
| title_fullStr | GLUT3 regulates alternative macrophage signaling through a glucose transport–independent role |
| title_full_unstemmed | GLUT3 regulates alternative macrophage signaling through a glucose transport–independent role |
| title_short | GLUT3 regulates alternative macrophage signaling through a glucose transport–independent role |
| title_sort | glut3 regulates alternative macrophage signaling through a glucose transport independent role |
| url | https://doi.org/10.1172/JCI174540 |
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