A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity
Here, the authors report a live chimeric DENV2/4 EDII virus, encoding DENV2 and DENV4 neutralizing epitopes, that replicates efficiently in primates and simultaneously elicits neutralizing DENV2 and DENV4 type-specific antibodies, providing domain-specific diagnostic reagents and simplified vaccine...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36702-x |
| _version_ | 1827983553875410944 |
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| author | Ellen Young Boyd Yount Petraleigh Pantoja Sandra Henein Rita M. Meganck Jennifer McBride Jennifer E. Munt Thomas J. Baric Deanna Zhu Trevor Scobey Stephanie Dong Longping V. Tse Melween I. Martinez Armando G. Burgos Rachel L. Graham Laura White Aravinda DeSilva Carlos A. Sariol Ralph S. Baric |
| author_facet | Ellen Young Boyd Yount Petraleigh Pantoja Sandra Henein Rita M. Meganck Jennifer McBride Jennifer E. Munt Thomas J. Baric Deanna Zhu Trevor Scobey Stephanie Dong Longping V. Tse Melween I. Martinez Armando G. Burgos Rachel L. Graham Laura White Aravinda DeSilva Carlos A. Sariol Ralph S. Baric |
| author_sort | Ellen Young |
| collection | DOAJ |
| description | Here, the authors report a live chimeric DENV2/4 EDII virus, encoding DENV2 and DENV4 neutralizing epitopes, that replicates efficiently in primates and simultaneously elicits neutralizing DENV2 and DENV4 type-specific antibodies, providing domain-specific diagnostic reagents and simplified vaccine strategies. |
| first_indexed | 2024-04-09T22:49:22Z |
| format | Article |
| id | doaj.art-6da0934f0e114ea8bd63f572e1f9e010 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:49:22Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6da0934f0e114ea8bd63f572e1f9e0102023-03-22T11:41:42ZengNature PortfolioNature Communications2041-17232023-03-0114111210.1038/s41467-023-36702-xA live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunityEllen Young0Boyd Yount1Petraleigh Pantoja2Sandra Henein3Rita M. Meganck4Jennifer McBride5Jennifer E. Munt6Thomas J. Baric7Deanna Zhu8Trevor Scobey9Stephanie Dong10Longping V. Tse11Melween I. Martinez12Armando G. Burgos13Rachel L. Graham14Laura White15Aravinda DeSilva16Carlos A. Sariol17Ralph S. Baric18Department of Epidemiology, Gillings School of Global Public Health, University of North CarolinaDepartment of Epidemiology, Gillings School of Global Public Health, University of North CarolinaUnit of Comparative Medicine, University of Puerto Rico-Medical Sciences CampusDepartment of Microbiology and Immunology, School of Medicine, University of North CarolinaDepartment of Molecular Microbiology and Immunology, Saint Louis UniversityDepartment of Epidemiology, Gillings School of Global Public Health, University of North CarolinaDepartment of Epidemiology, Gillings School of Global Public Health, University of North CarolinaDepartment of Epidemiology, Gillings School of Global Public Health, University of North CarolinaDepartment of Epidemiology, Gillings School of Global Public Health, University of North CarolinaDepartment of Epidemiology, Gillings School of Global Public Health, University of North CarolinaDepartment of Epidemiology, Gillings School of Global Public Health, University of North CarolinaDepartment of Molecular Microbiology and Immunology, Saint Louis UniversityCaribbean Primate Research Center, School of Medicine, University of Puerto Rico-Medical Sciences CampusCaribbean Primate Research Center, School of Medicine, University of Puerto Rico-Medical Sciences CampusDepartment of Epidemiology, Gillings School of Global Public Health, University of North CarolinaDepartment of Microbiology and Immunology, School of Medicine, University of North CarolinaDepartment of Microbiology and Immunology, School of Medicine, University of North CarolinaUnit of Comparative Medicine, University of Puerto Rico-Medical Sciences CampusDepartment of Epidemiology, Gillings School of Global Public Health, University of North CarolinaHere, the authors report a live chimeric DENV2/4 EDII virus, encoding DENV2 and DENV4 neutralizing epitopes, that replicates efficiently in primates and simultaneously elicits neutralizing DENV2 and DENV4 type-specific antibodies, providing domain-specific diagnostic reagents and simplified vaccine strategies.https://doi.org/10.1038/s41467-023-36702-x |
| spellingShingle | Ellen Young Boyd Yount Petraleigh Pantoja Sandra Henein Rita M. Meganck Jennifer McBride Jennifer E. Munt Thomas J. Baric Deanna Zhu Trevor Scobey Stephanie Dong Longping V. Tse Melween I. Martinez Armando G. Burgos Rachel L. Graham Laura White Aravinda DeSilva Carlos A. Sariol Ralph S. Baric A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity Nature Communications |
| title | A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity |
| title_full | A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity |
| title_fullStr | A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity |
| title_full_unstemmed | A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity |
| title_short | A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity |
| title_sort | live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual denv2 denv4 serotype specific immunity |
| url | https://doi.org/10.1038/s41467-023-36702-x |
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