Association of Single Nucleotide Polymorphisms in Toll-like Receptors with Acinetobacter baumanii Infectionin a Chinese Population
Background: During recent years, infection of Acinetobacter baumanii showed a rapid growth in hospitals and community. Toll-like receptors (TLRs) are the most important pattern recognition receptors, which play a critical role during recognizing invading pathogens by the natural immune system. Our o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2016-02-01
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| Series: | Iranian Journal of Public Health |
| Subjects: | |
| Online Access: | https://ijph.tums.ac.ir/index.php/ijph/article/view/5840 |
| _version_ | 1819236643073163264 |
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| author | Lei HE Maohu LIN Wensheng FAN Yunxi LIU Jijiang SUO Yubin XING Ning JIA |
| author_facet | Lei HE Maohu LIN Wensheng FAN Yunxi LIU Jijiang SUO Yubin XING Ning JIA |
| author_sort | Lei HE |
| collection | DOAJ |
| description | Background: During recent years, infection of Acinetobacter baumanii showed a rapid growth in hospitals and community. Toll-like receptors (TLRs) are the most important pattern recognition receptors, which play a critical role during recognizing invading pathogens by the natural immune system. Our objective was to determine the associations of TLRs polymorphisms with the susceptibility to A. baumanii infection in a Chinese population.
Methods: We carried out a case-control study, genotyping 13 polymorphisms of TLR-2, TLR-4, TLR-5 and TLR-9 genes on 423 A. baumanii-infected patients and 385 exposed controls. Thirteen SNPs at the TLR-2 (rs3804099, rs7656411 and rs76112010), TLR-4 (rs1927914, rs10759932 and rs11536889), TLR-5 (rs1341987, rs1640827, rs1861172, rs2241097, rs5744174 and rs17163737) and TLR9 (rs187084) genes were analyzed. SNP genotyping was performed using an improved multiplex ligation detection reaction (iMLDR) technique.
Results: The SNP of TLR-9, rs187084, was related to A. baumanii-infection significantly under recessive model (G/G, to A/A + G/A, P = 0.0064, OR = 0.59, 95% CI = 0.40-0.86) after adjustment with age. Besides, the haplotype GCG of TLR-4 was significantly associated with A. baumanii infection (P = 0.027).
Conclusion: TLR-4 and TLR-9 may be related to the susceptibility to A. baumanii infection in a Chinese population. |
| first_indexed | 2024-12-23T13:07:41Z |
| format | Article |
| id | doaj.art-6da2bcff50e84054a94d874338a7a619 |
| institution | Directory Open Access Journal |
| issn | 2251-6085 2251-6093 |
| language | English |
| last_indexed | 2024-12-23T13:07:41Z |
| publishDate | 2016-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-6da2bcff50e84054a94d874338a7a6192022-12-21T17:45:49ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932016-02-014514789Association of Single Nucleotide Polymorphisms in Toll-like Receptors with Acinetobacter baumanii Infectionin a Chinese PopulationLei HE0Maohu LIN1Wensheng FAN2Yunxi LIU3Jijiang SUO4Yubin XING5Ning JIA6Dept. of Hepabiliary Surgery, PLA General Hospital, Beijing 100853, ChinaDept. of Urological Surgery, the First Affiliated Hospital of PLA General Hospital, Beijing100051, ChinaDept. of Gynecology and Obstetrics, PLA General Hospital, Beijing100853,ChinaDept. of Nosocomial Infection and Disease Control, PLA General Hospital, Beijing100853,ChinaDept. of Nosocomial Infection and Disease Control, PLA General Hospital, Beijing100853,ChinaDept. of Nosocomial Infection and Disease Control, PLA General Hospital, Beijing100853,ChinaDept. of Nosocomial Infection and Disease Control, PLA General Hospital, Beijing100853,ChinaBackground: During recent years, infection of Acinetobacter baumanii showed a rapid growth in hospitals and community. Toll-like receptors (TLRs) are the most important pattern recognition receptors, which play a critical role during recognizing invading pathogens by the natural immune system. Our objective was to determine the associations of TLRs polymorphisms with the susceptibility to A. baumanii infection in a Chinese population. Methods: We carried out a case-control study, genotyping 13 polymorphisms of TLR-2, TLR-4, TLR-5 and TLR-9 genes on 423 A. baumanii-infected patients and 385 exposed controls. Thirteen SNPs at the TLR-2 (rs3804099, rs7656411 and rs76112010), TLR-4 (rs1927914, rs10759932 and rs11536889), TLR-5 (rs1341987, rs1640827, rs1861172, rs2241097, rs5744174 and rs17163737) and TLR9 (rs187084) genes were analyzed. SNP genotyping was performed using an improved multiplex ligation detection reaction (iMLDR) technique. Results: The SNP of TLR-9, rs187084, was related to A. baumanii-infection significantly under recessive model (G/G, to A/A + G/A, P = 0.0064, OR = 0.59, 95% CI = 0.40-0.86) after adjustment with age. Besides, the haplotype GCG of TLR-4 was significantly associated with A. baumanii infection (P = 0.027). Conclusion: TLR-4 and TLR-9 may be related to the susceptibility to A. baumanii infection in a Chinese population.https://ijph.tums.ac.ir/index.php/ijph/article/view/5840Acinetobacter baumaniiGene polymorphismsToll-like receptors |
| spellingShingle | Lei HE Maohu LIN Wensheng FAN Yunxi LIU Jijiang SUO Yubin XING Ning JIA Association of Single Nucleotide Polymorphisms in Toll-like Receptors with Acinetobacter baumanii Infectionin a Chinese Population Iranian Journal of Public Health Acinetobacter baumanii Gene polymorphisms Toll-like receptors |
| title | Association of Single Nucleotide Polymorphisms in Toll-like Receptors with Acinetobacter baumanii Infectionin a Chinese Population |
| title_full | Association of Single Nucleotide Polymorphisms in Toll-like Receptors with Acinetobacter baumanii Infectionin a Chinese Population |
| title_fullStr | Association of Single Nucleotide Polymorphisms in Toll-like Receptors with Acinetobacter baumanii Infectionin a Chinese Population |
| title_full_unstemmed | Association of Single Nucleotide Polymorphisms in Toll-like Receptors with Acinetobacter baumanii Infectionin a Chinese Population |
| title_short | Association of Single Nucleotide Polymorphisms in Toll-like Receptors with Acinetobacter baumanii Infectionin a Chinese Population |
| title_sort | association of single nucleotide polymorphisms in toll like receptors with acinetobacter baumanii infectionin a chinese population |
| topic | Acinetobacter baumanii Gene polymorphisms Toll-like receptors |
| url | https://ijph.tums.ac.ir/index.php/ijph/article/view/5840 |
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