Pharmacological induction of transforming growth factor-beta1 in rat models enhances radiation injury in the intestine and the heart.

Pharmacological induction of transforming growth factor-beta1 in rat models enhances radiation injury in the intestine and the heart.

Radiation therapy in the treatment of cancer is dose limited by radiation injury in normal tissues such as the intestine and the heart. To identify the mechanistic involvement of transforming growth factor-beta 1 (TGF-β1) in intestinal and cardiac radiation injury, we studied the influence of pharma...

Full description

Bibliographic Details
Main Authors:	Marjan Boerma, Junru Wang, Vijayalakshmi Sridharan, Jean-Marc Herbert, Martin Hauer-Jensen
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3723823?pdf=render

Similar Items

TLR4—A Pertinent Player in Radiation-Induced Heart Disease?
by: Basveshwar Gawali, et al.
Published: (2023-04-01)

C/EBPδ deficiency sensitizes mice to ionizing radiation-induced hematopoietic and intestinal injury.
by: Snehalata A Pawar, et al.
Published: (2014-01-01)

Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
by: David Casero, et al.
Published: (2017-08-01)

Effects of Simulated 5-Ion Galactic Cosmic Radiation on Function and Structure of the Mouse Heart
by: Ashley S. Nemec-Bakk, et al.
Published: (2023-03-01)

Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart
by: Vijayalakshmi Sridharan, et al.
Published: (2023-01-01)

Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin.
by: Vijayalakshmi Sridharan, et al.
Published: (2021-01-01)

Cebpd Is Essential for Gamma-Tocotrienol Mediated Protection against Radiation-Induced Hematopoietic and Intestinal Injury
by: Sudip Banerjee, et al.
Published: (2018-04-01)

Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction
by: Yaoxiang Li, et al.
Published: (2023-04-01)

One-carbon metabolism and ionizing radiation: a multifaceted interaction
by: Miousse Isabelle R., et al.
Published: (2017-05-01)

Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
by: Maarisha Upadhyay, et al.
Published: (2020-06-01)

Radiation Impacts Microbiota Compositions That Activate Transforming Growth Factor-Beta Expression in the Small Intestine
by: Irene Maier
Published: (2023-05-01)

Low doses of oxygen ion irradiation cause long-term damage to bone marrow hematopoietic progenitor and stem cells in mice.
by: Yingying Wang, et al.
Published: (2017-01-01)

Low Doses of Oxygen Ion Irradiation Cause Acute Damage to Hematopoietic Cells in Mice.
by: Jianhui Chang, et al.
Published: (2016-01-01)

Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure
by: Se-Ran Jun, et al.
Published: (2021-08-01)

Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate
by: Sarita Garg, et al.
Published: (2022-04-01)

Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery
by: Sarita Garg, et al.
Published: (2019-03-01)

Pharmacological preconditioning with vitamin C attenuates intestinal injury via the induction of heme oxygenase-1 after hemorrhagic shock in rats.
by: Bing Zhao, et al.
Published: (2014-01-01)

Pharmacology of Catechins in Ischemia-Reperfusion Injury of the Heart
by: Kristína Ferenczyová, et al.
Published: (2021-08-01)

Mitochondria and Pharmacologic Cardiac Conditioning—At the Heart of Ischemic Injury
by: Christopher Lotz, et al.
Published: (2021-03-01)

A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
by: Nousha Afshari, et al.
Published: (2024-01-01)

Radiation-Induced Intestinal Injury: Injury Mechanism and Potential Treatment Strategies
by: Qianying Lu, et al.
Published: (2023-12-01)

Induction of the interleukin 1 receptor antagonist protein by transforming growth factor-beta.
by: Turner, M, et al.
Published: (1991)

Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity
by: Rachel A. Schlaak, et al.
Published: (2020-02-01)

Disulfiram Protects Against Radiation-Induced Intestinal Injury in Mice
by: Qingwen Yuan, et al.
Published: (2022-04-01)

The Protective Effects of Apigenin Against Radiation‐Induced Intestinal Injury
by: Danjie Liu, et al.
Published: (2022-07-01)

Induction of transforming growth factor beta receptors following focal ischemia in the rat brain.
by: Gabriella Pál, et al.
Published: (2014-01-01)

Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice.
by: Rupak Pathak, et al.
Published: (2015-01-01)

Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model.
by: Chhanda Bose, et al.
Published: (2018-01-01)

Alteration of Metal Elements in Radiation Injury: Radiation-Induced Copper Accumulation Aggravates Intestinal Damage
by: Li Zhong, et al.
Published: (2020-01-01)

The Hypoxic Microenvironment of Breast Cancer Cells Promotes Resistance in Radiation Therapy
by: Cordell Gilreath, et al.
Published: (2021-02-01)

IKKβ regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells.
by: Lixian Wu, et al.
Published: (2011-04-01)

Late Effects of 1H + 16O on Short-Term and Object Memory, Hippocampal Dendritic Morphology and Mutagenesis
by: Frederico Kiffer, et al.
Published: (2020-06-01)

Protective effect and mechanism of citrulline on intestinal injury induced by radiation in mice
by: FENG Jundong, et al.
Published: (2024-02-01)

ACSL4 is essential for radiation-induced intestinal injury by initiating ferroptosis
by: Qian Ji, et al.
Published: (2022-07-01)

PAI-1-dependent endothelial cell death determines severity of radiation-induced intestinal injury.
by: Rym Abderrahmani, et al.
Published: (2012-01-01)

Intestine‐on‐a‐chip for intestinal disease study and pharmacological research
by: Dongxue Zhang, et al.
Published: (2023-02-01)

Pharmacological and non- pharmacological treatment of hypertension: A review article
by: Marjan Seyedmazhari
Published: (2013-01-01)

Single-cell map of dynamic cellular microenvironment of radiation-induced intestinal injury
by: Hao Lu, et al.
Published: (2023-12-01)

Inhibition of EphA2 by Dasatinib Suppresses Radiation-Induced Intestinal Injury
by: Areumnuri Kim, et al.
Published: (2020-11-01)

A Fiber-Rich Diet and Radiation-Induced Injury in the Murine Intestinal Mucosa
by: Dilip Kumar Malipatlolla, et al.
Published: (2021-12-01)