Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies
Bone metastasis is a common complication of many types of advanced cancer, including breast cancer. Bone metastasis may cause severe pain, fractures, and hypercalcemia, rendering clinical management challenging and substantially reducing the quality of life and overall survival (OS) time of breast c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/23/5727 |
| _version_ | 1797463549374627840 |
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| author | Lulian Pang Chen Gan Jian Xu Yingxue Jia Jiaying Chai Runze Huang Anlong Li Han Ge Sheng Yu Huaidong Cheng |
| author_facet | Lulian Pang Chen Gan Jian Xu Yingxue Jia Jiaying Chai Runze Huang Anlong Li Han Ge Sheng Yu Huaidong Cheng |
| author_sort | Lulian Pang |
| collection | DOAJ |
| description | Bone metastasis is a common complication of many types of advanced cancer, including breast cancer. Bone metastasis may cause severe pain, fractures, and hypercalcemia, rendering clinical management challenging and substantially reducing the quality of life and overall survival (OS) time of breast cancer patients. Studies have revealed that bone metastasis is related to interactions between tumor cells and the bone microenvironment, and involves complex molecular biological mechanisms, including colonization, osteolytic destruction, and an immunosuppressive bone microenvironment. Agents inhibiting bone metastasis (such as bisphosphate and denosumab) alleviate bone destruction and improve the quality of life of breast cancer patients with bone metastasis. However, the prognosis of these patients remains poor, and the specific biological mechanism of bone metastasis is incompletely understood. Additional basic and clinical studies are urgently needed, to further explore the mechanism of bone metastasis and develop new therapeutic drugs. This review presents a summary of the molecular mechanisms and therapeutic strategies of bone metastasis of breast cancer, aiming to improve the quality of life and prognosis of breast cancer patients and provide a reference for future research directions. |
| first_indexed | 2024-03-09T17:52:19Z |
| format | Article |
| id | doaj.art-6da3e289b29e440fbe82b58e10e9a5d3 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T17:52:19Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-6da3e289b29e440fbe82b58e10e9a5d32023-11-24T10:37:41ZengMDPI AGCancers2072-66942022-11-011423572710.3390/cancers14235727Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic StrategiesLulian Pang0Chen Gan1Jian Xu2Yingxue Jia3Jiaying Chai4Runze Huang5Anlong Li6Han Ge7Sheng Yu8Huaidong Cheng9Department of Oncology, Anhui Medical University, Hefei 230601, ChinaDepartment of Oncology, Anhui Medical University, Hefei 230601, ChinaDepartment of Oncology, Anhui Medical University, Hefei 230601, ChinaDepartment of Oncology, Anhui Medical University, Hefei 230601, ChinaDepartment of Oncology, Anhui Medical University, Hefei 230601, ChinaDepartment of Oncology, Anhui Medical University, Hefei 230601, ChinaDepartment of Oncology, Anhui Medical University, Hefei 230601, ChinaDepartment of Oncology, Anhui Medical University, Hefei 230601, ChinaDepartment of Oncology, Anhui Medical University, Hefei 230601, ChinaDepartment of Oncology, Anhui Medical University, Hefei 230601, ChinaBone metastasis is a common complication of many types of advanced cancer, including breast cancer. Bone metastasis may cause severe pain, fractures, and hypercalcemia, rendering clinical management challenging and substantially reducing the quality of life and overall survival (OS) time of breast cancer patients. Studies have revealed that bone metastasis is related to interactions between tumor cells and the bone microenvironment, and involves complex molecular biological mechanisms, including colonization, osteolytic destruction, and an immunosuppressive bone microenvironment. Agents inhibiting bone metastasis (such as bisphosphate and denosumab) alleviate bone destruction and improve the quality of life of breast cancer patients with bone metastasis. However, the prognosis of these patients remains poor, and the specific biological mechanism of bone metastasis is incompletely understood. Additional basic and clinical studies are urgently needed, to further explore the mechanism of bone metastasis and develop new therapeutic drugs. This review presents a summary of the molecular mechanisms and therapeutic strategies of bone metastasis of breast cancer, aiming to improve the quality of life and prognosis of breast cancer patients and provide a reference for future research directions.https://www.mdpi.com/2072-6694/14/23/5727breast cancerbone metastasesmolecular mechanismstherapeutic strategies |
| spellingShingle | Lulian Pang Chen Gan Jian Xu Yingxue Jia Jiaying Chai Runze Huang Anlong Li Han Ge Sheng Yu Huaidong Cheng Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies Cancers breast cancer bone metastases molecular mechanisms therapeutic strategies |
| title | Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies |
| title_full | Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies |
| title_fullStr | Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies |
| title_full_unstemmed | Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies |
| title_short | Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies |
| title_sort | bone metastasis of breast cancer molecular mechanisms and therapeutic strategies |
| topic | breast cancer bone metastases molecular mechanisms therapeutic strategies |
| url | https://www.mdpi.com/2072-6694/14/23/5727 |
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