Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress

Particulate matter 2.5 (PM<sub>2.5</sub>) levels are associated with adverse pregnancy outcomes. In this retrospective cohort study, we examined whether the concentration of indoor PM<sub>2.5</sub> affected pregnancy outcomes. Additionally, we evaluated biomarkers of pregnanc...

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Main Authors: Sunwha Park, Eunjin Kwon, Gain Lee, Young-Ah You, Soo Min Kim, Young Min Hur, Sooyoung Jung, Yongho Jee, Mi Hye Park, Sung Hun Na, Young-Han Kim, Geum Joon Cho, Jin-Gon Bae, Soo-Jeong Lee, Sun Hwa Lee, Young Ju Kim
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Antioxidants
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Online Access:https://www.mdpi.com/2076-3921/12/11/1916
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author Sunwha Park
Eunjin Kwon
Gain Lee
Young-Ah You
Soo Min Kim
Young Min Hur
Sooyoung Jung
Yongho Jee
Mi Hye Park
Sung Hun Na
Young-Han Kim
Geum Joon Cho
Jin-Gon Bae
Soo-Jeong Lee
Sun Hwa Lee
Young Ju Kim
author_facet Sunwha Park
Eunjin Kwon
Gain Lee
Young-Ah You
Soo Min Kim
Young Min Hur
Sooyoung Jung
Yongho Jee
Mi Hye Park
Sung Hun Na
Young-Han Kim
Geum Joon Cho
Jin-Gon Bae
Soo-Jeong Lee
Sun Hwa Lee
Young Ju Kim
author_sort Sunwha Park
collection DOAJ
description Particulate matter 2.5 (PM<sub>2.5</sub>) levels are associated with adverse pregnancy outcomes. In this retrospective cohort study, we examined whether the concentration of indoor PM<sub>2.5</sub> affected pregnancy outcomes. Additionally, we evaluated biomarkers of pregnancy-related complications caused by fine dust. We collected clinical information and data based on residential addresses from the Air Korea database to assess PM<sub>2.5</sub> exposure levels. As a multicenter prospective cohort study, we measured the indoor PM<sub>2.5</sub> concentration and inflammatory and oxidative stress markers. The PM<sub>2.5</sub> concentration of the low-birth-weight (LBW) delivery group was 27.21 μg/m<sup>3</sup>, which was significantly higher than that of the normal-birth-weight (NBW) group (26.23 μg/m<sup>3</sup>) (<i>p</i> = 0.02). When the newborns were divided by sex, the PM<sub>2.5</sub> concentration of the LBW group was 27.89 μg/m<sup>3</sup> in male infants, which was significantly higher than that of the NBW group (26.26 μg/m<sup>3</sup>) (<i>p</i> = 0.01). In the prospective study, 8-hydroxy-2-deoxyguanosine significantly increased in the high-concentration group (113.55 ng/mL, compared with 92.20 ng/mL in the low-concentration group); in the high-concentration group, the rates of preterm birth (PTB) and small size for gestational age significantly increased (<i>p</i> < 0.01, <i>p</i> = 0.01). This study showed an association between PM<sub>2.5</sub>, oxidative stress, and fetal growth, with the PTB group being more vulnerable.
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spelling doaj.art-6da3e35b16754da6bc8247c80e42f23c2023-11-24T14:25:34ZengMDPI AGAntioxidants2076-39212023-10-011211191610.3390/antiox12111916Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative StressSunwha Park0Eunjin Kwon1Gain Lee2Young-Ah You3Soo Min Kim4Young Min Hur5Sooyoung Jung6Yongho Jee7Mi Hye Park8Sung Hun Na9Young-Han Kim10Geum Joon Cho11Jin-Gon Bae12Soo-Jeong Lee13Sun Hwa Lee14Young Ju Kim15Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul 07985, Republic of KoreaDivision of Allergy and Respiratory Disease Research, Department of Chronic Disease Convergence Research, Korea National Institute of Health, Cheongju-si 28159, Republic of KoreaGraduate Program in System Health Science and Engineering, Ewha Womans University, Seoul 07985, Republic of KoreaDepartment of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul 07985, Republic of KoreaGraduate Program in System Health Science and Engineering, Ewha Womans University, Seoul 07985, Republic of KoreaDepartment of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul 07985, Republic of KoreaDepartment of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul 07985, Republic of KoreaAdvanced Biomedical Research Institute, Ewha Womans University Seoul Hospital, Seoul 07804, Republic of KoreaDepartment of Obstetrics and Gynecology, Ewha Womans University Seoul Hospital, Seoul 07804, Republic of KoreaDepartment of Obstetrics and Gynecology, School of Medicine, Kangwon National University, Chuncheon-si 24289, Republic of KoreaDepartment of Obstetrics and Gynecology, College of Medicine, Yonsei University, Seoul 03722, Republic of KoreaDepartment of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul 02841, Republic of KoreaDepartment of Obstetrics and Gynecology, School of Medicine, Keimyung University, Dongsan Medical Center, Daegu 42601, Republic of KoreaDepartment of Obstetrics and Gynecology, College of Medicine, Ulsan University, Ulsan 44610, Republic of KoreaSeegene Medical Foundation, Seoul 04805, Republic of KoreaDepartment of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul 07985, Republic of KoreaParticulate matter 2.5 (PM<sub>2.5</sub>) levels are associated with adverse pregnancy outcomes. In this retrospective cohort study, we examined whether the concentration of indoor PM<sub>2.5</sub> affected pregnancy outcomes. Additionally, we evaluated biomarkers of pregnancy-related complications caused by fine dust. We collected clinical information and data based on residential addresses from the Air Korea database to assess PM<sub>2.5</sub> exposure levels. As a multicenter prospective cohort study, we measured the indoor PM<sub>2.5</sub> concentration and inflammatory and oxidative stress markers. The PM<sub>2.5</sub> concentration of the low-birth-weight (LBW) delivery group was 27.21 μg/m<sup>3</sup>, which was significantly higher than that of the normal-birth-weight (NBW) group (26.23 μg/m<sup>3</sup>) (<i>p</i> = 0.02). When the newborns were divided by sex, the PM<sub>2.5</sub> concentration of the LBW group was 27.89 μg/m<sup>3</sup> in male infants, which was significantly higher than that of the NBW group (26.26 μg/m<sup>3</sup>) (<i>p</i> = 0.01). In the prospective study, 8-hydroxy-2-deoxyguanosine significantly increased in the high-concentration group (113.55 ng/mL, compared with 92.20 ng/mL in the low-concentration group); in the high-concentration group, the rates of preterm birth (PTB) and small size for gestational age significantly increased (<i>p</i> < 0.01, <i>p</i> = 0.01). This study showed an association between PM<sub>2.5</sub>, oxidative stress, and fetal growth, with the PTB group being more vulnerable.https://www.mdpi.com/2076-3921/12/11/19168-hydroxy-2-deoxyguanosinebiomarkerindoor airlow birth weightparticulate matterpreterm birth
spellingShingle Sunwha Park
Eunjin Kwon
Gain Lee
Young-Ah You
Soo Min Kim
Young Min Hur
Sooyoung Jung
Yongho Jee
Mi Hye Park
Sung Hun Na
Young-Han Kim
Geum Joon Cho
Jin-Gon Bae
Soo-Jeong Lee
Sun Hwa Lee
Young Ju Kim
Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress
Antioxidants
8-hydroxy-2-deoxyguanosine
biomarker
indoor air
low birth weight
particulate matter
preterm birth
title Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress
title_full Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress
title_fullStr Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress
title_full_unstemmed Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress
title_short Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress
title_sort effect of particulate matter 2 5 on fetal growth in male and preterm infants through oxidative stress
topic 8-hydroxy-2-deoxyguanosine
biomarker
indoor air
low birth weight
particulate matter
preterm birth
url https://www.mdpi.com/2076-3921/12/11/1916
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