SRC kinase-mediated signaling pathways and targeted therapies in breast cancer
Abstract Breast cancer (BC) has been ranked the most common malignant tumor throughout the world and is also a leading cause of cancer-related deaths among women. SRC family kinases (SFKs) belong to the non-receptor tyrosine kinase (nRTK) family, which has eleven members sharing similar structure an...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-12-01
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| Series: | Breast Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13058-022-01596-y |
| _version_ | 1828083075083403264 |
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| author | Juan Luo Hailin Zou Yibo Guo Tongyu Tong Liping Ye Chengming Zhu Liang Deng Bo Wang Yihang Pan Peng Li |
| author_facet | Juan Luo Hailin Zou Yibo Guo Tongyu Tong Liping Ye Chengming Zhu Liang Deng Bo Wang Yihang Pan Peng Li |
| author_sort | Juan Luo |
| collection | DOAJ |
| description | Abstract Breast cancer (BC) has been ranked the most common malignant tumor throughout the world and is also a leading cause of cancer-related deaths among women. SRC family kinases (SFKs) belong to the non-receptor tyrosine kinase (nRTK) family, which has eleven members sharing similar structure and function. Among them, SRC is the first identified proto-oncogene in mammalian cells. Oncogenic overexpression or activation of SRC has been revealed to play essential roles in multiple events of BC progression, including tumor initiation, growth, metastasis, drug resistance and stemness regulations. In this review, we will first give an overview of SRC kinase and SRC-relevant functions in various subtypes of BC and then systematically summarize SRC-mediated signaling transductions, with particular emphasis on SRC-mediated substrate phosphorylation in BC. Furthermore, we will discuss the progress of SRC-based targeted therapies in BC and the potential future direction. |
| first_indexed | 2024-04-11T04:04:05Z |
| format | Article |
| id | doaj.art-6da5a0794afb46b6b7bc96cdc7936608 |
| institution | Directory Open Access Journal |
| issn | 1465-542X |
| language | English |
| last_indexed | 2024-04-11T04:04:05Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Breast Cancer Research |
| spelling | doaj.art-6da5a0794afb46b6b7bc96cdc79366082023-01-01T12:30:37ZengBMCBreast Cancer Research1465-542X2022-12-0124111710.1186/s13058-022-01596-ySRC kinase-mediated signaling pathways and targeted therapies in breast cancerJuan Luo0Hailin Zou1Yibo Guo2Tongyu Tong3Liping Ye4Chengming Zhu5Liang Deng6Bo Wang7Yihang Pan8Peng Li9Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityDepartment of General Surgery, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Oncology, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityAbstract Breast cancer (BC) has been ranked the most common malignant tumor throughout the world and is also a leading cause of cancer-related deaths among women. SRC family kinases (SFKs) belong to the non-receptor tyrosine kinase (nRTK) family, which has eleven members sharing similar structure and function. Among them, SRC is the first identified proto-oncogene in mammalian cells. Oncogenic overexpression or activation of SRC has been revealed to play essential roles in multiple events of BC progression, including tumor initiation, growth, metastasis, drug resistance and stemness regulations. In this review, we will first give an overview of SRC kinase and SRC-relevant functions in various subtypes of BC and then systematically summarize SRC-mediated signaling transductions, with particular emphasis on SRC-mediated substrate phosphorylation in BC. Furthermore, we will discuss the progress of SRC-based targeted therapies in BC and the potential future direction.https://doi.org/10.1186/s13058-022-01596-yBreast cancerSRC kinaseSignaling transductionTyrosine phosphorylationTargeted therapy |
| spellingShingle | Juan Luo Hailin Zou Yibo Guo Tongyu Tong Liping Ye Chengming Zhu Liang Deng Bo Wang Yihang Pan Peng Li SRC kinase-mediated signaling pathways and targeted therapies in breast cancer Breast Cancer Research Breast cancer SRC kinase Signaling transduction Tyrosine phosphorylation Targeted therapy |
| title | SRC kinase-mediated signaling pathways and targeted therapies in breast cancer |
| title_full | SRC kinase-mediated signaling pathways and targeted therapies in breast cancer |
| title_fullStr | SRC kinase-mediated signaling pathways and targeted therapies in breast cancer |
| title_full_unstemmed | SRC kinase-mediated signaling pathways and targeted therapies in breast cancer |
| title_short | SRC kinase-mediated signaling pathways and targeted therapies in breast cancer |
| title_sort | src kinase mediated signaling pathways and targeted therapies in breast cancer |
| topic | Breast cancer SRC kinase Signaling transduction Tyrosine phosphorylation Targeted therapy |
| url | https://doi.org/10.1186/s13058-022-01596-y |
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