Enhancing the dissolution rate of mefenamic acid with solid dispersion system using avicel PH-101
Mefenamic acid, based on the Biopharmaceutics Classification System (BCS), is a class II drug that has high permeability but low water solubility. To improve its intrinsic dissolution rate, it is usually combined with a hydrophilic and porous drug carrier like Avicel to create a solid dispersion. Th...
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| Format: | Article |
| Language: | English |
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Universitas Ahmad Dahlan
2019-05-01
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| Series: | Pharmaciana |
| Subjects: | |
| Online Access: | http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/10809/pdf_111 |
| _version_ | 1818790854709477376 |
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| author | Widyasari Putranti Lina Widiyastuti Fitri Ulfani |
| author_facet | Widyasari Putranti Lina Widiyastuti Fitri Ulfani |
| author_sort | Widyasari Putranti |
| collection | DOAJ |
| description | Mefenamic acid, based on the Biopharmaceutics Classification System (BCS), is a class II drug that has high permeability but low water solubility. To improve its intrinsic dissolution rate, it is usually combined with a hydrophilic and porous drug carrier like Avicel to create a solid dispersion. This study aimed to enhance the intrinsic dissolution rate of mefenamic acid using a solid dispersion with Avicel PH-101. The test of intrinsic dissolution rate involved a rotational speed of 60 rpm and CO2-free water with a temperature of 37°C as a medium. The interaction of mefenamic acid and Avicel PH-101 was analyzed with FTIR and DSC spectroscopy. The test results showed that the intrinsic dissolution rates (in mg.cm-2.minute-1) of three replications of mefenamic acid, Solid Dispersion of Mefenamic Acid and Avicel PH-101 (SDMA) with 1:1 ratio, SDMA with 1:2 ratio, Physical Mixture of Mefenamic Acid and Avicel PH-101 (PMMA) with 1:1 ratio, and PMMA with 1:2 ratio were (8.0x10-4 ± 3.0x10-4), (38.0x10-4 ± 3.0x10-4), (67.0x10-4 ± 10.0x10-4), (20.0x10-4 ± 6.0x10-4), and (44.0x10-4 ± 14.0x10-4), respectively. The interaction between mefenamic acid and Avicel PH-101 created a hydrogen bonding, as evidenced by the shift in the peaks of FTIR spectra. Based on the DSC thermogram, the mefenamic acid-Avicel PH-101 interaction shifted the steep peak on the curve of mefenamic acid slightly. Avicel PH-101 in this solid dispersion can increase the intrinsic dissolution rate of mefenamic acid through hydrogen bonding instead of decreasing its crystalline structure into an amorphous from. |
| first_indexed | 2024-12-18T15:02:05Z |
| format | Article |
| id | doaj.art-6da8a21cd8ac4af09441790f2b48c389 |
| institution | Directory Open Access Journal |
| issn | 2088-4559 2477-0256 |
| language | English |
| last_indexed | 2024-12-18T15:02:05Z |
| publishDate | 2019-05-01 |
| publisher | Universitas Ahmad Dahlan |
| record_format | Article |
| series | Pharmaciana |
| spelling | doaj.art-6da8a21cd8ac4af09441790f2b48c3892022-12-21T21:03:52ZengUniversitas Ahmad DahlanPharmaciana2088-45592477-02562019-05-019111912810.12928/pharmaciana.v9i1.10809Enhancing the dissolution rate of mefenamic acid with solid dispersion system using avicel PH-101Widyasari Putranti0Lina Widiyastuti1Fitri Ulfani2Faculty of Pharmacy, Universitas Ahmad Dahlan YogyakartaFaculty of Pharmacy, Universitas Ahmad Dahlan YogyakartaFaculty of Pharmacy, Universitas Ahmad Dahlan YogyakartaMefenamic acid, based on the Biopharmaceutics Classification System (BCS), is a class II drug that has high permeability but low water solubility. To improve its intrinsic dissolution rate, it is usually combined with a hydrophilic and porous drug carrier like Avicel to create a solid dispersion. This study aimed to enhance the intrinsic dissolution rate of mefenamic acid using a solid dispersion with Avicel PH-101. The test of intrinsic dissolution rate involved a rotational speed of 60 rpm and CO2-free water with a temperature of 37°C as a medium. The interaction of mefenamic acid and Avicel PH-101 was analyzed with FTIR and DSC spectroscopy. The test results showed that the intrinsic dissolution rates (in mg.cm-2.minute-1) of three replications of mefenamic acid, Solid Dispersion of Mefenamic Acid and Avicel PH-101 (SDMA) with 1:1 ratio, SDMA with 1:2 ratio, Physical Mixture of Mefenamic Acid and Avicel PH-101 (PMMA) with 1:1 ratio, and PMMA with 1:2 ratio were (8.0x10-4 ± 3.0x10-4), (38.0x10-4 ± 3.0x10-4), (67.0x10-4 ± 10.0x10-4), (20.0x10-4 ± 6.0x10-4), and (44.0x10-4 ± 14.0x10-4), respectively. The interaction between mefenamic acid and Avicel PH-101 created a hydrogen bonding, as evidenced by the shift in the peaks of FTIR spectra. Based on the DSC thermogram, the mefenamic acid-Avicel PH-101 interaction shifted the steep peak on the curve of mefenamic acid slightly. Avicel PH-101 in this solid dispersion can increase the intrinsic dissolution rate of mefenamic acid through hydrogen bonding instead of decreasing its crystalline structure into an amorphous from.http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/10809/pdf_111avicel ph-101intrinsic dissolutionmefenamic acidsolid dispersion |
| spellingShingle | Widyasari Putranti Lina Widiyastuti Fitri Ulfani Enhancing the dissolution rate of mefenamic acid with solid dispersion system using avicel PH-101 Pharmaciana avicel ph-101 intrinsic dissolution mefenamic acid solid dispersion |
| title | Enhancing the dissolution rate of mefenamic acid with solid dispersion system using avicel PH-101 |
| title_full | Enhancing the dissolution rate of mefenamic acid with solid dispersion system using avicel PH-101 |
| title_fullStr | Enhancing the dissolution rate of mefenamic acid with solid dispersion system using avicel PH-101 |
| title_full_unstemmed | Enhancing the dissolution rate of mefenamic acid with solid dispersion system using avicel PH-101 |
| title_short | Enhancing the dissolution rate of mefenamic acid with solid dispersion system using avicel PH-101 |
| title_sort | enhancing the dissolution rate of mefenamic acid with solid dispersion system using avicel ph 101 |
| topic | avicel ph-101 intrinsic dissolution mefenamic acid solid dispersion |
| url | http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/10809/pdf_111 |
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