The Effect on the Kidney in Patients With Anti-N-methyl D-aspartate Receptor Antibody Encephalitis
Objectives: The function of the N-methyl-D-aspartate receptor (NMDAR) in the kidney has been studied. However, the effect on the kidney from anti-NAMDAR antibody encephalitis has not been investigated thus far.Methods: Case data were collected from 82 patients with anti-NMDAR antibody encephalitis a...
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| Format: | Article |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.601495/full |
| _version_ | 1818416916233977856 |
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| author | Lizhi Liu Lizhi Liu Meifeng Gu Jia Liu Qing Liu Xiaofeng Xu Rong Fan Fuhua Peng Ying Jiang |
| author_facet | Lizhi Liu Lizhi Liu Meifeng Gu Jia Liu Qing Liu Xiaofeng Xu Rong Fan Fuhua Peng Ying Jiang |
| author_sort | Lizhi Liu |
| collection | DOAJ |
| description | Objectives: The function of the N-methyl-D-aspartate receptor (NMDAR) in the kidney has been studied. However, the effect on the kidney from anti-NAMDAR antibody encephalitis has not been investigated thus far.Methods: Case data were collected from 82 patients with anti-NMDAR antibody encephalitis and 166 age- and sex-matched healthy controls (HCs). Clinical characteristics, urinalysis [including urine pH and urine specific gravity (SG)], serum creatinine (Scr), and estimated glomerular filtration rate (eGFR) based on Cr levels were evaluated.Results: At initial admission, urine pH levels and urine SG levels in anti-NMDAR antibody encephalitis patients were significantly higher and lower, respectively, than HCs (both p < 0.001). There were no significant differences in Scr and eGFR between anti-NMDAR antibody encephalitis patients and HCs. Urine pH levels in patients with anti-NMDAR antibody <1:32 were significantly lower than those in patients with anti-NMDAR antibody ≥1:32 (p = 0.029). Urine pH levels were significantly lower (p = 0.004) and urine SG levels were significantly higher (p = 0.027) in a follow-up evaluation 3 months after treatment.Conclusions: The changes in urinalysis occur in patients with anti-NMDAR antibody encephalitis. The pathophysiological changes in anti-NMDAR antibody encephalitis were not limited to the CNS. |
| first_indexed | 2024-12-14T11:58:29Z |
| format | Article |
| id | doaj.art-6da964f3637943fbb4afb0d96bf926f9 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-14T11:58:29Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-6da964f3637943fbb4afb0d96bf926f92022-12-21T23:02:03ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-02-011210.3389/fneur.2021.601495601495The Effect on the Kidney in Patients With Anti-N-methyl D-aspartate Receptor Antibody EncephalitisLizhi Liu0Lizhi Liu1Meifeng Gu2Jia Liu3Qing Liu4Xiaofeng Xu5Rong Fan6Fuhua Peng7Ying Jiang8Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Neurology, Huizhou Hospital of Traditional Chinese Medicine, Huizhou, ChinaDepartment of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Neurology, Huizhou Hospital of Traditional Chinese Medicine, Huizhou, ChinaDepartment of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaObjectives: The function of the N-methyl-D-aspartate receptor (NMDAR) in the kidney has been studied. However, the effect on the kidney from anti-NAMDAR antibody encephalitis has not been investigated thus far.Methods: Case data were collected from 82 patients with anti-NMDAR antibody encephalitis and 166 age- and sex-matched healthy controls (HCs). Clinical characteristics, urinalysis [including urine pH and urine specific gravity (SG)], serum creatinine (Scr), and estimated glomerular filtration rate (eGFR) based on Cr levels were evaluated.Results: At initial admission, urine pH levels and urine SG levels in anti-NMDAR antibody encephalitis patients were significantly higher and lower, respectively, than HCs (both p < 0.001). There were no significant differences in Scr and eGFR between anti-NMDAR antibody encephalitis patients and HCs. Urine pH levels in patients with anti-NMDAR antibody <1:32 were significantly lower than those in patients with anti-NMDAR antibody ≥1:32 (p = 0.029). Urine pH levels were significantly lower (p = 0.004) and urine SG levels were significantly higher (p = 0.027) in a follow-up evaluation 3 months after treatment.Conclusions: The changes in urinalysis occur in patients with anti-NMDAR antibody encephalitis. The pathophysiological changes in anti-NMDAR antibody encephalitis were not limited to the CNS.https://www.frontiersin.org/articles/10.3389/fneur.2021.601495/fullanti-N-methyl-D-aspartate receptor encephalitisestimated glomerular filtration rate (eGFR)renal functionurinalysisurine pHurine specific gravity (USG) |
| spellingShingle | Lizhi Liu Lizhi Liu Meifeng Gu Jia Liu Qing Liu Xiaofeng Xu Rong Fan Fuhua Peng Ying Jiang The Effect on the Kidney in Patients With Anti-N-methyl D-aspartate Receptor Antibody Encephalitis Frontiers in Neurology anti-N-methyl-D-aspartate receptor encephalitis estimated glomerular filtration rate (eGFR) renal function urinalysis urine pH urine specific gravity (USG) |
| title | The Effect on the Kidney in Patients With Anti-N-methyl D-aspartate Receptor Antibody Encephalitis |
| title_full | The Effect on the Kidney in Patients With Anti-N-methyl D-aspartate Receptor Antibody Encephalitis |
| title_fullStr | The Effect on the Kidney in Patients With Anti-N-methyl D-aspartate Receptor Antibody Encephalitis |
| title_full_unstemmed | The Effect on the Kidney in Patients With Anti-N-methyl D-aspartate Receptor Antibody Encephalitis |
| title_short | The Effect on the Kidney in Patients With Anti-N-methyl D-aspartate Receptor Antibody Encephalitis |
| title_sort | effect on the kidney in patients with anti n methyl d aspartate receptor antibody encephalitis |
| topic | anti-N-methyl-D-aspartate receptor encephalitis estimated glomerular filtration rate (eGFR) renal function urinalysis urine pH urine specific gravity (USG) |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.601495/full |
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